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2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase

This is an abbreviated version!
For detailed information about phosphatidylinositol-4,5-bisphosphate 3-kinase, go to the full flat file.

Word Map on EC 2.7.1.153

Reaction

ATP
+
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
=
ADP
 +
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate

Synonyms

class I phosphoinositide 3-kinase, class I PI3K, class IA phosphatidylinositol 3-kinase, class IA phosphatidylinositol-4,5-bisphosphate 3-kinase, CXCR2/phosphatidylinositol 3-kinase gamma, kinase (phosphorylating), phosphatidylinositol 4,5-diphosphate 3-, More, p101-PI3K, p110alpha, p110beta, p110delta, p110delta PI 3-kinase, p110gamma/p101, P120-PI3K, phosphatidyl-inositol-3-kinase, phosphatidylinositol (4,5)-bisphosphate 3-hydroxykinase, phosphatidylinositol 3'-kinase, phosphatidylinositol 3-hydroxyl kinase, phosphatidylinositol 3-kinase alpha, phosphatidylinositol 3-kinase gamma, phosphatidylinositol-4,5-bisphosphate 3-kinase, phosphoinositide 3-kinase, phosphoinositide 3-kinase p110delta, phosphoinositol 3-kinase, PI 3-K, PI 3-kinase, PI-3K, PI3-K, PI3-kinase, PI3K, PI3K p110delta, PI3Kalpha, PI3Kbeta, PI3Kdelta, PI3Kgamma, PI3Kp110delta, PIK3, PIK3CA, Pik3r1, PtdIns(4,5)P2 3-OH kinase, PtdIns-3-kinase p101, PtdIns-3-kinase p110, PtdInsP 3-OH-kinase, type I phosphoinositide 3-kinase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.153 phosphatidylinositol-4,5-bisphosphate 3-kinase

Source Tissue

Source Tissue on EC 2.7.1.153 - phosphatidylinositol-4,5-bisphosphate 3-kinase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
an airway epithelial cell line
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
the cells are located at the terminal bronchi, and have the capacity to selfrenew and undergo multi-linage differentiation
Manually annotated by BRENDA team
-
recombinant isoforms PI3Kalpha, beta, delta and gamma
Manually annotated by BRENDA team
-
thyroid follicular cell line
Manually annotated by BRENDA team
renal proximal tubule epithelial cell
Manually annotated by BRENDA team
primary human acute myeloid leukemia (AML) cells
Manually annotated by BRENDA team
high expression
Manually annotated by BRENDA team
high expression
Manually annotated by BRENDA team
-
68% of clinical cases and the MCL cell lines harbor a gain of PIK3 catalytic subunit alpha gene copy number. In addition, cases with increased PIK3CA gene copy number have elevated PIK3CA mRNA levels
Manually annotated by BRENDA team
-
PI3Kdelta isoform is most prominently expressed in myeloid cells
Manually annotated by BRENDA team
-
p110delta is highly expressed. p110delta as an important signaling component for efficient axonal elongation in the developing and regenerating nervous system
Manually annotated by BRENDA team
-
a pivotal region in reflex regulation of arterial pressure in the brain stem. Quantitative determination of expression levels of specific class I PI3K subunits, p85alpha, p85beta, p110alpha, p110beta, p110delta, and p110gamma, in the nucleus tractus solitarii of spontaneously hypertensive rats, overview
Manually annotated by BRENDA team
-
osteoclasts express multiple regulatory subunits of class IA PI3-K, although the expression of the full-length form of p85alpha is most abundant
Manually annotated by BRENDA team
rat osteosarcoma cell line
Manually annotated by BRENDA team
-
an epithelial ovarian cancer cell line SKOV3 with constitutively active PI3K
Manually annotated by BRENDA team
-
tracheal smooth muscle
Manually annotated by BRENDA team
-
all cell lines express the catalytic subunit isoforms p110alpha, p110beta, p110gamma, and p110delta
Manually annotated by BRENDA team
additional information