2.7.1.156: adenosylcobinamide kinase
This is an abbreviated version!
For detailed information about adenosylcobinamide kinase, go to the full flat file.
Word Map on EC 2.7.1.156
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2.7.1.156
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typhimurium
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guanylylation
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nucleoside
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cobalamin
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nonorthologous
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enterica
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nucleotidyltransferase
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adenosylcobalamin
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cobamide
- 2.7.1.156
- typhimurium
-
guanylylation
- nucleoside
- cobalamin
-
nonorthologous
- enterica
-
nucleotidyltransferase
- adenosylcobalamin
- cobamide
Reaction
Synonyms
adenosylcobinamide kinase, adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase, AdoCbi kinase/AdoCbi-phosphate guanylyltransferase, ATP/GTP:AdoCbi kinase, bifunctional CobU enzyme, CobP, CobU, CobU AdoCbi kinase, CobU protein, GTP:adenosylcobinamide-phosphate guanylyltransferase, GTP:AdoCbi-P kinase, GTP:AdoCbi-phosphate guanylyltransferase, NTP:adenosylcobinamide kinase, NTP:AdoCbi kinase
ECTree
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Substrates Products
Substrates Products on EC 2.7.1.156 - adenosylcobinamide kinase
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REACTION DIAGRAM
adenosylcobinamide + ATP
adenosylcobinamide phosphate + ADP
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-
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ir
adenosylcobinamide + GTP
adenosylcobinamide phosphate + GDP
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-
-
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ir
dATP + adenosylcobinamide
adenosylcobinamide phosphate + dADP
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-
-
?
dGTP + adenosylcobinamide
adenosylcobinamide phosphate + dGDP
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-
-
?
adenosylcobinamide-GDP + diphosphate
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-
-
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?
adenosylcobinamide phosphate + GTP
adenosylcobinamide-GDP + diphosphate
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-
-
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ir
adenosylcobinamide phosphate + GTP
adenosylcobinamide-GDP + diphosphate
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adenosylcobinamide-phosphate guanylyltransferase activity
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-
ir
2',5'-dideoxyadenosylcobinamide phosphate + ADP
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highest kinase activity
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?
ATP + 2',5'-dideoxyadenosylcobinamide
2',5'-dideoxyadenosylcobinamide phosphate + ADP
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highest kinase activity
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?
5'-deoxyadenosylcobinamide phosphate + ADP
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highest kinase activity
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?
ATP + 5'-deoxyadenosylcobinamide
5'-deoxyadenosylcobinamide phosphate + ADP
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highest kinase activity
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?
ATP + 5'-deoxyadenosylcobinamide
5'-deoxyadenosylcobinamide phosphate + ADP
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-
-
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?
ATP + 5'-deoxyadenosylcobinamide
5'-deoxyadenosylcobinamide phosphate + ADP
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highest kinase activity, product generation relative to adenosylcobinamide 102%
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?
5'-deoxycytosylcobinamide phosphate + ADP
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substantial amount of activity retains, about 65% of the activity with AdoCbi
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?
ATP + 5'-deoxycytosylcobinamide
5'-deoxycytosylcobinamide phosphate + ADP
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substantial amount of activity retains, about 65% of the activity with AdoCbi
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?
ATP + 5'-deoxycytosylcobinamide
5'-deoxycytosylcobinamide phosphate + ADP
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about 65% of the activity with AdoCbi
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?
5'-deoxyguanosylcobinamide phosphate + ADP
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substantial amount of activity retains, about 65% of the activity with AdoCbi
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?
ATP + 5'-deoxyguanosylcobinamide
5'-deoxyguanosylcobinamide phosphate + ADP
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substantial amount of activity retains, about 65% of the activity with AdoCbi
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?
5'-deoxyinosylcobinamide phosphate + ADP
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substantial amount of activity retains, about 65% of the activity with AdoCbi
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?
ATP + 5'-deoxyinosylcobinamide
5'-deoxyinosylcobinamide phosphate + ADP
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substantial amount of activity retains, about 65% of the activity with AdoCbi
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?
ATP + 5'-deoxyinosylcobinamide
5'-deoxyinosylcobinamide phosphate + ADP
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about 55% of the activity with AdoCbi
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?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
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cobalamin biosynthesis, involved in de novo synthesis of vitamin B12
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?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
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-
-
?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
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cobalamin biosynthesis, involved in de novo synthesis of vitamin B12
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?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
-
-
-
?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
-
cobalamin biosynthesis, involved in de novo synthesis of vitamin B12
-
?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
-
-
-
?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
-
cobalamin biosynthesis, involved in de novo synthesis of vitamin B12
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?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
-
-
-
?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
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cobalamin biosynthesis, involved in de novo synthesis of vitamin B12, uses GTP to guanylate itself, then transfers this GMP group to AdoCbi-P to yield AdoCbi-GDP, the final product of the reaction, CobU enzyme in vivo is always guanylated, guanylation is necessary for both kinase and guanyltransferase activity
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?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
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-
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?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
-
-
-
?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
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-
-
?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
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-
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?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
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assembly of the nucleotide loop of cobalamin
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?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
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cobalamin biosynthesis, involved in de novo synthesis of vitamin B12
-
?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
-
cobalamin biosynthesis, involved in de novo synthesis of vitamin B12
-
?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
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late steps of cobalamin biosynthesis, involved in de novo synthesis of vitamin B12, nucleotide loop assembly, enzyme functions only if Salmonella typhimurium is assimilating cobinamide from its environment, CobU becomes less active during the kinase reaction due to the formation of a covalent CobU-AMP complex that holds CobU in an altered conformation
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?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
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adenosylcobinamide kinase activity
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ir
GTP + adenosylcobinamide
adenosylcobinamide phosphate + GDP
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-
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?
GTP + adenosylcobinamide
adenosylcobinamide phosphate + GDP
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-
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?
GTP + adenosylcobinamide
adenosylcobinamide phosphate + GDP
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-
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?
GTP + adenosylcobinamide
adenosylcobinamide phosphate + GDP
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-
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?
GTP + adenosylcobinamide
adenosylcobinamide phosphate + GDP
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-
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?
GTP + adenosylcobinamide
adenosylcobinamide phosphate + GDP
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-
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?
GTP + adenosylcobinamide
adenosylcobinamide phosphate + GDP
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-
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?
GTP + adenosylcobinamide
adenosylcobinamide phosphate + GDP
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-
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?
GTP + adenosylcobinamide
adenosylcobinamide phosphate + GDP
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assembly of the nucleotide loop of cobalamin
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?
?
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enzyme can bind CTP, UTP, and dCTP, but product formation is not observed, only ATP or GTP generate a catalytically competent conformation of the enzyme, no activity is observed if (CN)2Cbi is used as substrate
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?
additional information
?
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(CN)2Cbi is no substrate, no product formation with CTP, UTP or dCTP
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?
additional information
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CobU does not have any detectable ATP:adenosyltransferase activity
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?
additional information
?
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the enzyme is involved in adenosylcobalamin de novo biosynthesis, overview
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additional information
?
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CobU enzyme is required for synthesis of both coenzyme B12 (alpha ligand: 5,6-dimethylbenzimidazole) and pseudo-coenzyme B12 (alpha ligand: adenine).
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?
additional information
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CobU enzyme of the nucleotide loop assembly pathway is a bifunctional enzyme with adenosylcobinamide and adenosylcobinamide-phosphate guanylyltransferase activity, important for de novo synthesis and for cobinamide salvaging
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?