2.7.1.156: adenosylcobinamide kinase

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For detailed information about adenosylcobinamide kinase, go to the full flat file.

Reaction

Synonyms

adenosylcobinamide kinase, adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase, AdoCbi kinase/AdoCbi-phosphate guanylyltransferase, ATP/GTP:AdoCbi kinase, bifunctional CobU enzyme, CobP, CobU, CobU AdoCbi kinase, CobU protein, GTP:adenosylcobinamide-phosphate guanylyltransferase, GTP:AdoCbi-P kinase, GTP:AdoCbi-phosphate guanylyltransferase, NTP:adenosylcobinamide kinase, NTP:AdoCbi kinase

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.156 adenosylcobinamide kinase

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Results	in table
1	Activating Compound
21074	AA Sequence
1	CAS Registry Number
5	Cloned(Commentary)
4	Cofactor
3	Crystallization (Commentary)
1	General Stability
5	Inhibitors
2	KM Value [mM]
6	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
15	Organism
1	Oxidation Stability
6	Pathway
3	PDB ID
2	pH Optimum
1	pH Range
3	pI Value
4	Protein Variants
6	Purification (Commentary)
3	Reaction
2	Reaction Type
15	Reference
2	Source Tissue
5	Specific Activity [micromol/min/mg]
1	Storage Stability
56	Substrates and Products (Substrate)
4	Subunits
36	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.7.1.156 - adenosylcobinamide kinase

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SYSTEMATIC NAME

IUBMB Comments

RTP:adenosylcobinamide phosphotransferase

In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyse reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl). CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, alpha-ribazole. The second branch of the nucleotide loop assembly pathway is the cobinamide (Cbi) activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by Cob U. The final step in adenosylcobalamin biosynthesis is the condensation of AdoCbi-GDP with alpha-ribazole, which is catalysed by EC 2.7.8.26, adenosylcobinamide-GDP ribazoletransferase (CobS), to yield adenosylcobalamin. CobU is a bifunctional enzyme that has both kinase (EC 2.7.1.156) and guanylyltransferase (EC 2.7.7.62, adenosylcobinamide-phosphate guanylyltransferase) activities. However, both activities are not required at all times. The kinase activity has been proposed to function only when S. typhimurium is assimilating cobinamide whereas the guanylyltransferase activity is required for both assimilation of exogenous cobinamide and for de novo synthesis of adenosylcobalamin [4].