2.7.1.159: inositol-1,3,4-trisphosphate 5/6-kinase
This is an abbreviated version!
For detailed information about inositol-1,3,4-trisphosphate 5/6-kinase, go to the full flat file.
Word Map on EC 2.7.1.159
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2.7.1.159
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phytic
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polyphosphate
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hexakisphosphate
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dehydration
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itpks
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2-kinase
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phosphorus
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pentakisphosphate
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signalosome
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lipid-independent
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tnfalpha-induced
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1,3,4,5,6-pentakisphosphate
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monophosphatase
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photomorphogenesis
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1,4,5-tris-phosphate
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1,3,4,6-tetrakisphosphate
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phytate
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imp
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ikappabalpha
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atp-grasp
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agriculture
- 2.7.1.159
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phytic
- polyphosphate
-
hexakisphosphate
- dehydration
-
itpks
-
2-kinase
- phosphorus
- pentakisphosphate
-
signalosome
-
lipid-independent
-
tnfalpha-induced
- 1,3,4,5,6-pentakisphosphate
-
monophosphatase
-
photomorphogenesis
-
1,4,5-tris-phosphate
- 1,3,4,6-tetrakisphosphate
- phytate
- imp
- ikappabalpha
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atp-grasp
- agriculture
Reaction
Synonyms
1,3,4-trisphosphate 5/6-kinase, 5/6 kinase, 5/6-kinase, At2G43980, AtITPK1, AtITPK2, AtITPK3, AtITPK4, GmItpk2, inositol 1,3,4 tris phosphate 5/6 kinase-2, inositol 1,3,4 trisphosphate kinase-2, inositol 1,3,4-triphosphate 5/6 kinase, inositol 1,3,4-triphosphate 5/6-kinase, inositol 1,3,4-trisphosphate 5/6 kinase-2, inositol 1,3,4-trisphosphate 5/6-kinase, inositol 1,3,4-trisphosphate 5/6-kinase 1, inositol 1,3,4-trisphosphate 5/6-kinase 4, inositol 1,3,4-trisphosphate 5/6-kinase6, inositol 1,4,5 trisphosphate 3/6 kinase, inositol-1,3,4-trisphosphate kinase, Ins(1,3,4)P3 5/6-kinase, IP56K, Ipk2, ITPK, Itpk-1, ITPK1, ITPK2, ITPK3, More, Os09g0518700, OsITL1, OsITPK6
ECTree
2.7.1.159 inositol-1,3,4-trisphosphate 5/6-kinaseAdvanced search results
results (
results (Engineering
Engineering on EC 2.7.1.159 - inositol-1,3,4-trisphosphate 5/6-kinase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
P522L
ositpk6 mutant, the line with the P522L amino acid substitution has agronomic performance (seed weight, germination, and seedling growth) similar to that of its wild-type parent
additional information
additional information
construction of an enzyme-deficient mutant line, phenotype with reduced hypocotyl
additional information
construction of the homogenous At4g08170 mutant (SALK_120653C, NASCcode N653925) carrying a T-DNA insertion in the intron in wild-type line Col-0
additional information
functional analysis of itpk2-1 mutant (SAIL_25_H09), phenotype, overview
additional information
generation of itpk1-1 mutants, phenotype, overview. Genetic interaction analysis of bifunctional ITPK1 (EC 2.7.1.159/EC 2.7.1.134) and IPK1 (EC 2.7.1.158) with a genetic cross between ipk1-1 and itpk1 mutants. The ipk1-1 itpk1 double mutants exhibit more severe growth defects than single mutants and those that proceeded to the reproductive stage bore aborted seeds. Common elevation of D/L-Ins(3,4,5,6)P4 in itpk1 and ipk1-1 mutants
additional information
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construction of the homogenous At4g08170 mutant (SALK_120653C, NASCcode N653925) carrying a T-DNA insertion in the intron in wild-type line Col-0
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additional information
construction of diverse mutants and analysis of the function of the residues in catalysis and substrate binding, overview
additional information
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enzyme overexpression in HEK-293 cells inhibits TNFalpha-induced activation of caspases-8, -3, and -9, siRNA gene silencing of the enzyme in HeLa cells results in higher susceptibility of the cells to TNFalpha-induced apoptosis
additional information
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enzyme silencing in HeLa cells decreases the levels of inositol pentakisphosphate and inositol hexakisphosphate, while overexpression in HEK-293 cells increases the levels of InsP4, InsP5, and InsP6, overview
additional information
OsITPK6 mutants are generated by CRISPR/Cas9-mediated mutagenesis, generation of 23 hygromycin phosphotransferase (HPT)-positive T0 plants transformed with the CRISPR/Cas9 vector pH-itpk6. Genotyping of gene ITPK6, the ositpk6_1 (a 6-nt in-frame deletion) mutation results in the loss of two amino acids at positions 91 to 92. In contrast, all the other three mutations, i.e. ositpk6_2 (a 1-nt insertion), ositpk6_3 (a 5-nt deletion), and ositpk6_4 (a 2-nt deletion), generate a premature stop codon almost right after the mutation site and, hence, significantly shorten the encoded proteins. Consequently, the ositpk6_2, _3 and _4 mutant alleles are predicted to produce proteins of only 105, 103, and 104 amino acids, respectively. The two amino acids missing in the ositpk6_1 mutant are located in a highly conserved segment, suggesting the mutation of ositpk6_1 might have a potential functional consequence. Plant growth of mutants ositpk6_2, _3, and _4 is significantly impaired. Their panicles are significantly shorter (30.1%, 28.8%, and 29.1%, respectively) compared to wild-type parental cultivar Xidao 1, phenotypes, overview. Numbers and lengths of root from mutant plants are reduced under salt stress compared to wild-type
