2.7.1.164: O-phosphoseryl-tRNASec kinase
This is an abbreviated version!
For detailed information about O-phosphoseryl-tRNASec kinase, go to the full flat file.
Word Map on EC 2.7.1.164
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2.7.1.164
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selenocysteine
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selenoproteins
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sep-trna:sec-trna
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selenophosphate
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jannaschii
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sepsecs
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decoding
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serylates
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ser-trnasec
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methanocaldococcus
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methanococcus
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anticodon
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aminoacylated
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trna-dependent
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selenide
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selenocysteine-specific
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selenocysteinyl-trna
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eukarya
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trnasersec
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aminoacyl-trnas
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maripaludis
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d-stem
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aa-trnas
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amidotransferases
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amppnp
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trnaser
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misacylated
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serrs
- 2.7.1.164
- selenocysteine
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selenoproteins
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sep-trna:sec-trna
- selenophosphate
- jannaschii
- sepsecs
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decoding
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serylates
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ser-trnasec
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methanocaldococcus
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methanococcus
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anticodon
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aminoacylated
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trna-dependent
- selenide
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selenocysteine-specific
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selenocysteinyl-trna
- eukarya
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trnasersec
- aminoacyl-trnas
- maripaludis
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d-stem
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aa-trnas
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amidotransferases
- amppnp
- trnaser
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misacylated
- serrs
Reaction
Synonyms
O-phosphoseryl-tRNA kinase, O-phosphoseryl-tRNA(Sec) kinase, O-phosphoseryl-tRNASec kinase, phosphoseryl-tRNASec kinase, phosphoseryl-tRNA[Ser]Sec kinase, PSTK, Tb10.6k15.1110, TbPSTK
ECTree
2.7.1.164 O-phosphoseryl-tRNASec kinaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 2.7.1.164 - O-phosphoseryl-tRNASec kinase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + L-seryl-tRNASec
ADP + O-phospho-L-seryl-tRNASec
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?
ATP + L-seryl-tRNASec
ADP + O-phospho-L-seryl-tRNASec
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?
ATP + L-seryl-tRNASec
ADP + O-phospho-L-seryl-tRNASec
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?
ATP + L-seryl-tRNASec
ADP + O-phospho-L-seryl-tRNASec
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?
ATP + L-seryl-tRNASec
ADP + O-phospho-L-seryl-tRNASec
Pstk is a limiting factor for hepatic selenoprotein biosynthesis, and its mRNA expression is most strongly affected during the lipopolysaccharide (LPS)-induced acute-phase response
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?
ATP + L-seryl-tRNASec
ADP + O-phospho-L-seryl-tRNASec
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null mutants of PSTK abolish selenoprotein synthesis, demonstrating the essentiality of the enzyme for the formation of L-selenocysteinyl-tRNASec. Growth of the knockout strain is not impaired. Thus, unlike mammals, trypanosomes do not require selenoproteins for viability
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?
ATP + L-seryl-tRNASec
ADP + O-phospho-L-seryl-tRNASec
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?
ATP + L-seryl-tRNASec
ADP + O-phospho-L-seryl-tRNASec
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?
ATP + seryl-tRNASec
ADP + O-phospho-L-seryl-tRNASec
L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS)
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?
ATP + seryl-tRNASec
ADP + O-phospho-L-seryl-tRNASec
L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS)
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