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2.7.1.171: protein-fructosamine 3-kinase

This is an abbreviated version!
For detailed information about protein-fructosamine 3-kinase, go to the full flat file.

Word Map on EC 2.7.1.171

Reaction

ATP
+
[protein]-N6-D-fructosyl-L-lysine
=
ADP
 +
[protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine

Synonyms

AtFN3K, FL3P, FN3K, fructosamine 3 kinase, fructosamine 3-kinase, fructosamine-3-kinase, fructose-3-kinase, HsFN3K, ketosamine 3-kinase 1

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.171 protein-fructosamine 3-kinase

Expression

Expression on EC 2.7.1.171 - protein-fructosamine 3-kinase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
highest levels of FN3K expression are found in tissues known to be susceptible to glycation and diabetic complications such as kidney and neurons. Cultured fibroblasts treated with conditions mimicking the hormonal and biochemical profile of the diabetic state show no changes in fructosamine-3-kinase expression relative to untreated cells. FN3K acts as protein repair enzyme and is expressed constitutively in human cells independently of some of the variables altered in the diabetic state
-
mildly glycated casein in a standard diet stimulates 3-deoxyglucosone levels 10–20fold in the plasma and approximately 3fold in the kidney compared with a control diet containing identical constituents
-
no regulation of the expression of fructose-3-kinase is observed in human fibroblasts treated with conditions mimicking the hormonal and biochemical profile of the diabetic state
-
rats are starved for 2 days or rendered diabetic with streptozotocin and analyzed 5 days later. No detectable change in the activity of fructosamine 3-kinase is observed in liver, heart, kidney, and brain
-
the down-regulation of FN3K gene expression in cancer tissue compared with normal mucosa is a characteristic only of the left-sided tumours of the colon
-
the expression of the genes for FN3K appears to be constitutive and unaffected by environmental signals