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2.7.1.171: protein-fructosamine 3-kinase

This is an abbreviated version!
For detailed information about protein-fructosamine 3-kinase, go to the full flat file.

Word Map on EC 2.7.1.171

Reaction

ATP
+
[protein]-N6-D-fructosyl-L-lysine
=
ADP
 +
[protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine

Synonyms

AtFN3K, FL3P, FN3K, fructosamine 3 kinase, fructosamine 3-kinase, fructosamine-3-kinase, fructose-3-kinase, HsFN3K, ketosamine 3-kinase 1

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.171 protein-fructosamine 3-kinase

KI Value

KI Value on EC 2.7.1.171 - protein-fructosamine 3-kinase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
3-O-methylsorbitol-lysine
-
inhibitors based on sorbitol show competitive inhibition of the fructoseamine-3-kinase reaction but also prevent the formation of 3-deoxyglucosone, because there is no spontaneous decomposition of the product to 3-deoxyglucosone. For compounds blocked at C3, also there is no product formed. The Ki values of these compounds are approx. 0.5 mM. Although high for an in vivo drug, their apparent low toxicity make it possible to use them, at least in animals, to lower 3-deoxyglucosone levels