2.7.1.172: protein-ribulosamine 3-kinase
This is an abbreviated version!
For detailed information about protein-ribulosamine 3-kinase, go to the full flat file.
Word Map on EC 2.7.1.172
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2.7.1.172
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deglycation
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erythrocytes
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ribose
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amadori
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5-phosphate
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fructoselysine
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nonenzymatic
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protein-bound
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maillard
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erythrose
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haemoglobin
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decomposing
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tata-less
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transglycation
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sphingosine
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protein-repair
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caat-less
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ketoamine
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endproducts
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non-physiological
- 2.7.1.172
-
deglycation
- erythrocytes
- ribose
-
amadori
- 5-phosphate
- fructoselysine
-
nonenzymatic
-
protein-bound
-
maillard
- erythrose
- haemoglobin
-
decomposing
-
tata-less
-
transglycation
- sphingosine
-
protein-repair
-
caat-less
-
ketoamine
-
endproducts
-
non-physiological
Reaction
Synonyms
FN3K-related protein, FN3K-RP, Fn3KRP, fructosamine 3-kinase-related protein, fructosamine-3-kinase-related protein, fructosamine-3-kinase–related protein, ketosamine 3-kinase 2, ribulosamine/erythrulosamine 3-kinase
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General Information
General Information on EC 2.7.1.172 - protein-ribulosamine 3-kinase
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physiological function
FN3K-RP can act inside erythrocytes as a deglycating enzyme by converting ketoamines into unstable phosphate esters. Potential physiological substrates are psicosamines, which appear to be formed slowly from fructosamines
physiological function
CS-0777, a candidate compound for autoimmune diseases, becomes phosphorylated to an active metabolite, M1, by fructosamine 3-kinase (FN3K, EC 2.7.1.171) and FN3K-related protein (FN3K-RP), and (2R)-2-amino-2-methyl-4-(1-methyl)-5-[4-(4-methylphenyl)butanoyl]-1H-pyrrol-2-yl)butyl dihydrogen phosphate is reverted back to CS-0777 by alkaline phosphatase (ALP) in the body