2.7.1.173: nicotinate riboside kinase

This is an abbreviated version!
For detailed information about nicotinate riboside kinase, go to the full flat file.

Reaction

Synonyms

More, NaR kinase, nicotinamide riboside kinase, nicotinamide riboside kinase 1, nicotinamide riboside kinase 2, nicotinic acid riboside kinase, nicotinic acid riboside kinase 1, NMRK1, NMRK2, NR kinase, Nrk, NRK1, Nrk2, ribosylnicotinic acid kinase

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.173 nicotinate riboside kinase

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Results	in table
12	AA Sequence
1	Application
6	Cloned(Commentary)
8	Cofactor
2	Crystallization (Commentary)
1	Expression
16	General Information
14	kcat/KM [mM/s]
14	KM Value [mM]
5	Metals/Ions
9	Natural Substrates/ Products (Substrates)
9	Organism
3	Pathway
1	PDB ID
3	pH Optimum
6	Protein Variants
4	Purification (Commentary)
2	Reaction
8	Reference
13	Source Tissue
1	Specific Activity [micromol/min/mg]
26	Substrates and Products (Substrate)
2	Subunits
27	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
14	Turnover Number [1/s]

Engineering

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Engineering on EC 2.7.1.173 - nicotinate riboside kinase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

D35A

Homo sapiens

Q9NPI5, Q9NWW6

site-directed mutagenesis of Nrk2

718250

D36A

Homo sapiens

Q9NPI5, Q9NWW6

site-directed mutagenesis of Nrk1

718250

E100A

Homo sapiens

Q9NPI5, Q9NWW6

site-directed mutagenesis of Nrk2, mutant activity in ATP-dependent phosphorylation is below the level of detection

718250

E174R

Homo sapiens

Q9NPI5, Q9NWW6

site-directed mutagenesis of Nrk2

718250

E98A

Homo sapiens

Q9NPI5, Q9NWW6

site-directed mutagenesis of Nrk1, mutant activity in ATP-dependent phosphorylation is below the level of detection

718250

additional information

Homo sapiens

Q9NWW6

enzyme NRK1 specific silencing in human ovarian carcinoma cell line OVCAR-3 by NRK1-specific siRNA

739212