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2.7.1.189: autoinducer-2 kinase

This is an abbreviated version!
For detailed information about autoinducer-2 kinase, go to the full flat file.

Word Map on EC 2.7.1.189

Reaction

ATP
+
(S)-4,5-dihydroxypentane-2,3-dione
=
ADP
 +
(S)-4-hydroxypentane-2,3-dione 5-phosphate

Synonyms

AI-2 kinase, AI-2 processing kinase, Lsr kinase, lsrK, LsrK kinase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.189 autoinducer-2 kinase

Expression

Expression on EC 2.7.1.189 - autoinducer-2 kinase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
cAMP-catabolite activator protein (CAP)-dependent activation of the lsr transcription. A cAMP-CAP-independent mechanism of lsr activation involves LsrR, the lsr operon repressor
-
glycerol-3-phosphate inhibits lsr operon transcription activation by cAMP-catabolite activator protein, CAP. Dihydroxyacetone phosphate represses lsr transcription by a cAMP-CAP-independent mechanism involving LsrR, the lsr operon repressor, dihydroxyacetone phosphate causes repression by an LsrR-dependent and catabolite repression-independent route
-
LsrR regulates the expression of both lsrACDBFG and lsrRK operons
-
phosphorylated 4,5-dihydroxy-2,3-pentanedione (P-DPD) binds specifically to the repressor of the lsr operon, LsrR, consistent with P-DPD being the inducer of the lsr operon
transcription of lsrK is not regulated by luxS or AI-2