2.7.1.2: glucokinase
This is an abbreviated version!
For detailed information about glucokinase, go to the full flat file.
Word Map on EC 2.7.1.2
-
2.7.1.2
-
pancreatic
-
islet
-
hepatocytes
-
hexokinase
-
mellitus
-
glycogen
-
beta-cell
-
hyperglycemia
-
glucose-6-phosphatase
-
fructose
-
pancreas
-
phosphoenolpyruvate
-
maturity-onset
-
carboxykinase
-
glucagon
-
glucose-stimulated
-
glucose-induced
-
6-phosphate
-
triglyceride
-
gluconeogenesis
-
phosphofructokinase
-
hypoglycemic
-
monogenic
-
antidiabetic
-
non-insulin-dependent
-
pepck
-
gluconeogenic
-
c-peptide
-
ins-1e
-
insulinomas
-
glp-1
-
niddm
-
insulin-secreting
-
sulfonylurea
-
g6pase
-
glut-2
-
hyperinsulinemia
-
glucose-sensing
-
glucose-dependent
-
insulin-producing
-
glucose-lowering
-
2.7.1.1
-
2,6-bisphosphate
-
kcnj11
-
substrate-2
-
hyperinsulinism
-
perivenous
-
fructokinase
-
diazoxide
-
glucose-responsive
- 2.7.1.2
- pancreatic
- islet
- hepatocytes
- hexokinase
- mellitus
- glycogen
- beta-cell
- hyperglycemia
- glucose-6-phosphatase
- fructose
- pancreas
- phosphoenolpyruvate
-
maturity-onset
-
carboxykinase
- glucagon
-
glucose-stimulated
-
glucose-induced
- 6-phosphate
- triglyceride
-
gluconeogenesis
-
phosphofructokinase
-
hypoglycemic
-
monogenic
-
antidiabetic
-
non-insulin-dependent
- pepck
-
gluconeogenic
- c-peptide
-
ins-1e
- insulinomas
- glp-1
- niddm
-
insulin-secreting
- sulfonylurea
- g6pase
-
glut-2
- hyperinsulinemia
-
glucose-sensing
-
glucose-dependent
-
insulin-producing
-
glucose-lowering
-
2.7.1.1
-
2,6-bisphosphate
-
kcnj11
- substrate-2
- hyperinsulinism
-
perivenous
- fructokinase
- diazoxide
-
glucose-responsive
Reaction
Synonyms
ATP-dependent glucokinase, ATP-GLK, GK, GlcK, glk, Glk1, glucokinase (phosphorylating), glucokinase 1, kinase, gluco- (phosphorylating), KlGlk1, KLLA0C01155g, LmGlcK, NagC, NfGlck, SgGlkA, Sw0678, Sw2155, Sw3773, TcGlcK, TTE0090
ECTree
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Metals Ions
Metals Ions on EC 2.7.1.2 - glucokinase
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Ca2+
CaCl2
MnCl2 yields 9% of the activity observed when MgCl2 is included in the assay
Cd2+
Co2+
Cu2+
Mg2+
MgCl2
the enzyme functions best when MgCl2 is included in the assay
Mn2+
MnCl2
MnCl2 yields 40% of the activity observed when MgCl2 is included in the assay
Ni2+
Sr2+
Zn2+
additional information
CuCl2, CoCl2, ZnCl2 or CaCl2 have no appreciable effect on the enzyme activity
Ca2+
13.4% of the activity with Mg2+
Co2+
-
more efficient than Mg2+ in activation, relative rate 264%
0.4% of the activity with Mg2+
Mg2+
required, best activating cation
Mg2+
highest activity is observed in the presence of 5 mM of MgCl2
Mg2+
the enzyme is Mg2+- or Mn2+-dependent. KM: 0.38 mM
Mg2+
-
absolute requirement for divalent cation, 78% of the activity with Mn2+
Mg2+
clear requirement for a divalent metal ion and a strong preference for Mg2+
Mn2+
the enzyme is Mg2+- or Mn2+-dependent. KM: 0.4 mM
Mn2+
-
more efficient than Mg2+ in activation, relative rate 173%