2.7.1.2: glucokinase
This is an abbreviated version!
For detailed information about glucokinase, go to the full flat file.
Word Map on EC 2.7.1.2
-
2.7.1.2
-
pancreatic
-
islet
-
hepatocytes
-
hexokinase
-
mellitus
-
glycogen
-
beta-cell
-
hyperglycemia
-
glucose-6-phosphatase
-
fructose
-
pancreas
-
phosphoenolpyruvate
-
maturity-onset
-
carboxykinase
-
glucagon
-
glucose-stimulated
-
glucose-induced
-
6-phosphate
-
triglyceride
-
gluconeogenesis
-
phosphofructokinase
-
hypoglycemic
-
monogenic
-
antidiabetic
-
non-insulin-dependent
-
pepck
-
gluconeogenic
-
c-peptide
-
ins-1e
-
insulinomas
-
glp-1
-
niddm
-
insulin-secreting
-
sulfonylurea
-
g6pase
-
glut-2
-
hyperinsulinemia
-
glucose-sensing
-
glucose-dependent
-
insulin-producing
-
glucose-lowering
-
2.7.1.1
-
2,6-bisphosphate
-
kcnj11
-
substrate-2
-
hyperinsulinism
-
perivenous
-
fructokinase
-
diazoxide
-
glucose-responsive
- 2.7.1.2
- pancreatic
- islet
- hepatocytes
- hexokinase
- mellitus
- glycogen
- beta-cell
- hyperglycemia
- glucose-6-phosphatase
- fructose
- pancreas
- phosphoenolpyruvate
-
maturity-onset
-
carboxykinase
- glucagon
-
glucose-stimulated
-
glucose-induced
- 6-phosphate
- triglyceride
-
gluconeogenesis
-
phosphofructokinase
-
hypoglycemic
-
monogenic
-
antidiabetic
-
non-insulin-dependent
- pepck
-
gluconeogenic
- c-peptide
-
ins-1e
- insulinomas
- glp-1
- niddm
-
insulin-secreting
- sulfonylurea
- g6pase
-
glut-2
- hyperinsulinemia
-
glucose-sensing
-
glucose-dependent
-
insulin-producing
-
glucose-lowering
-
2.7.1.1
-
2,6-bisphosphate
-
kcnj11
- substrate-2
- hyperinsulinism
-
perivenous
- fructokinase
- diazoxide
-
glucose-responsive
Reaction
Synonyms
ATP-dependent glucokinase, ATP-GLK, GK, GlcK, glk, Glk1, glucokinase (phosphorylating), glucokinase 1, kinase, gluco- (phosphorylating), KlGlk1, KLLA0C01155g, LmGlcK, NagC, NfGlck, SgGlkA, Sw0678, Sw2155, Sw3773, TcGlcK, TTE0090
ECTree
2.7.1.2 glucokinaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.7.1.2 - glucokinase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
6-N-[N-(6-aminohexhyl)carbamoyl]ATP + D-glucose
6-N-[N-(6-aminohexhyl)carbamoyl]ADP + D-glucose 6-phosphate
adenosine 5'-triphosphate-polyamidoamine dendrimer + D-glucose
adenosine 5'-diphosphate-polyamidoamine dendrimer + D-glucose 6-phosphate
-
-
-
-
ir
ADP + D-glucose
AMP + D-glucose 6-phosphate
3% of the velocity with ATP
-
-
?
ATP + D-sorbitol
ADP + ?
at 10% of the activity as compared to D-glucose
-
-
?
ATP + N-acetyl-alpha-D-glucosamine
ADP + N-acetyl-alpha-D-glucosamine 6-phosphate
-
at pH 7.6: 50% of the activity with alpha-D-glucose, at pH 9.0: 5% of the activity with alpha-D-glucose
-
-
?
6-N-(carboxyethyl)ATP + D-glucose
6-N-(carboxyethyl)ADP + D-glucose 6-phosphate
-
-
-
-
?
6-N-(carboxyethyl)ATP + D-glucose
6-N-(carboxyethyl)ADP + D-glucose 6-phosphate
-
-
-
-
?
6-N-(carboxymethyl)ATP + D-glucose
6-N-(carboxymethyl)ADP + D-glucose 6-phosphate
-
-
-
-
?
6-N-(carboxymethyl)ATP + D-glucose
6-N-(carboxymethyl)ADP + D-glucose 6-phosphate
-
-
-
-
?
6-N-(succinyl)ATP + D-glucose
6-N-(succinyl)ADP + D-glucose 6-phosphate
-
-
-
-
?
6-N-(succinyl)ATP + D-glucose
6-N-(succinyl)ADP + D-glucose 6-phosphate
-
-
-
-
?
6-N-[N-(6-aminohexhyl)carbamoyl]ATP + D-glucose
6-N-[N-(6-aminohexhyl)carbamoyl]ADP + D-glucose 6-phosphate
-
-
-
-
?
6-N-[N-(6-aminohexhyl)carbamoyl]ATP + D-glucose
6-N-[N-(6-aminohexhyl)carbamoyl]ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
no reaction with the recombinant enzyme
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
26% of the activity with D-glucose
-
-
ir
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
no reaction with the recombinant enzyme
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
3% of the velocity with D-glucose
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
3% of the velocity with D-glucose
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
at 70% of the activity as compared to D-glucose
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
at 70% of the activity as compared to D-glucose
-
-
?
ATP + D-galactose
ADP + D-galactose
at 11% of the activity as compared to D-glucose
-
-
?
ATP + D-galactose
ADP + D-galactose
at 11% of the activity as compared to D-glucose
-
-
?
ATP + D-glucosamine
ADP + D-glucosamine 6-phosphate
-
no reaction with the recombinant enzyme
-
-
?
ATP + D-glucosamine
ADP + D-glucosamine 6-phosphate
-
-
-
?
ATP + D-glucosamine
ADP + D-glucosamine 6-phosphate
-
-
-
?
ATP + D-glucosamine
ADP + D-glucosamine 6-phosphate
D-glucose and D-glucosamine with nearly equal activity
-
-
?
ATP + D-glucosamine
ADP + D-glucosamine 6-phosphate
D-glucose and D-glucosamine with nearly equal activity
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
highly specific for D-glucose
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
specific for D-glucose, substrate binding site structure
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
highly specific for D-glucose
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
no activity with fructose
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
no activity with fructose
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
enzyme is only able to phosphorylate glucose
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
no activity with CTP, ADP, PPi or polyP
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
no activity with CTP, ADP, PPi or polyP
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
D-glucose and D-glucosamine with nearly equal activity
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
D-glucose and D-glucosamine with nearly equal activity
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
limited hexose substrate range, with the greatest activity observed with glucose
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
ATP is the most efficient phosphoryl donor
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
ATP is the most efficient phosphoryl donor
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
the enzyme initiates the intracellular glucose catabolism/metabolism, overview
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
the enzyme initiates the intracellular glucose catabolism/metabolism, overview
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
the enzyme phosphorylates various hexoses with a marked preference for glucose. ATP is the most preferred phosphoryl group donor. No activity with ADP or AMP as phosphoryl group donor
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
the enzyme phosphorylates various hexoses with a marked preference for glucose. ATP is the most preferred phosphoryl group donor. No activity with ADP or AMP as phosphoryl group donor
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
highly specific for D-glucose
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
the enzyme catalyzes the first step of the Embden-Meyerhoff pathway and the Entner-Douderoff pathway
-
-
ir
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
the enzyme is specific for D-glucose
-
-
ir
ATP + D-glucose
ADP + D-glucose 6-phosphate
enzyme is only able to phosphorylate glucose
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
highly specific for D-glucose
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
phosphorylates alpha-D-glucose and beta-D-glucose equally fast
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
no reaction with the recombinant enzyme
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
99% of the velocity with D-glucose
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
99% of the velocity with D-glucose
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
at 30% of the activity as compared to D-glucose
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
at 30% of the activity as compared to D-glucose
-
-
?
CTP + D-glucose
CDP + D-glucose 6-phosphate
38% of the velocity with ATP
-
-
?
CTP + D-glucose
CDP + D-glucose 6-phosphate
38% of the velocity with ATP
-
-
?
CTP + D-glucose
CDP + D-glucose 6-phosphate
-
10% of the activity with ATP
-
-
?
CTP + D-glucose
CDP + D-glucose 6-phosphate
-
less than 10% of the activity with ATP
-
-
?
CTP + D-glucose
CDP + D-glucose 6-phosphate
-
5% of the activity with ATP as phosphoryl donor
-
-
?
GTP + D-glucose
GDP + D-glucose 6-phosphate
-
no reaction with the recombinant enzyme
-
-
?
GTP + D-glucose
GDP + D-glucose 6-phosphate
-
30% of the activity with ATP
-
-
?
GTP + D-glucose
GDP + D-glucose 6-phosphate
71% compared to the activity with ATP
-
-
?
GTP + D-glucose
GDP + D-glucose 6-phosphate
71% compared to the activity with ATP
-
-
?
GTP + D-glucose
GDP + D-glucose 6-phosphate
-
less than 10% of ATP
-
-
?
GTP + D-glucose
GDP + D-glucose 6-phosphate
-
12% of the activity with ATP as phosphoryl donor
-
-
?
ITP + D-glucose
IDP + D-glucose 6-phosphate
-
75% of the activity with ATP
-
-
?
ITP + D-glucose
IDP + D-glucose 6-phosphate
-
30% of the activity with ATP
-
-
?
ITP + D-glucose
IDP + D-glucose 6-phosphate
-
30% of the activity with ATP
-
-
?
ITP + D-glucose
IDP + D-glucose 6-phosphate
-
less than 10% of the activity with ATP
-
-
?
ITP + D-glucose
IDP + D-glucose 6-phosphate
-
20% of the activity with ATP as phosphoryl donor
-
-
?
UTP + D-glucose
UDP + D-glucose 6-phosphate
-
no reaction with the recombinant enzyme
-
-
?
UTP + D-glucose
UDP + D-glucose 6-phosphate
-
32% of the activity with ATP
-
-
?
UTP + D-glucose
UDP + D-glucose 6-phosphate
85% compared to the activity with ATP
-
-
?
UTP + D-glucose
UDP + D-glucose 6-phosphate
85% compared to the activity with ATP
-
-
?
UTP + D-glucose
UDP + D-glucose 6-phosphate
-
12% of the activity with ATP
-
-
?
UTP + D-glucose
UDP + D-glucose 6-phosphate
-
less than 10% of the activity with ATP
-
-
?
UTP + D-glucose
UDP + D-glucose 6-phosphate
-
12% of the activity with ATP as phosphoryl donor
-
-
?
additional information
?
-
hexokinase, Hxk1, but not the glucokinase, Glk1, is required for normal growth and sugar metabolism, and for pathogenicity on fruits
-
-
?
additional information
?
-
-
hexokinase, Hxk1, but not the glucokinase, Glk1, is required for normal growth and sugar metabolism, and for pathogenicity on fruits
-
-
?
additional information
?
-
no substrate: N-acetyl-D-glucosamine, D-galactose
-
-
?
additional information
?
-
-
no substrate: N-acetyl-D-glucosamine, D-galactose
-
-
?
additional information
?
-
no substrate: N-acetyl-D-glucosamine, D-galactose
-
-
?
additional information
?
-
-
not: mannose, fructose, 2-deoxyglucose, UTP, ITP, GTP
-
-
?
additional information
?
-
-
recombinant enzymes NanK and YajF also utilize N-acetyl-D-mannosamine and D-fructose as substrates, respectively
-
-
?
additional information
?
-
fructose, xylose, galactose, sucrose, lactose, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate or fructose-6-phosphate as a phosphate acceptor. GTP, CTP, UTP, ADP or PPi does not serve as a phosphoryl donor
-
-
-
additional information
?
-
fructose, xylose, galactose, sucrose, lactose, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate or fructose-6-phosphate as a phosphate acceptor. GTP, CTP, UTP, ADP or PPi does not serve as a phosphoryl donor
-
-
-
additional information
?
-
-
fructose, xylose, galactose, sucrose, lactose, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate or fructose-6-phosphate as a phosphate acceptor. GTP, CTP, UTP, ADP or PPi does not serve as a phosphoryl donor
-
-
-
additional information
?
-
-
less than 10% of the activity with ATP: TTP
-
-
?
additional information
?
-
-
less than 10% of the activity with ATP: TTP
-
-
?
additional information
?
-
-
less than 10% of the activity with ATP: TTP
-
-
?
additional information
?
-
-
less than 10% of the activity with ATP: TTP
-
-
?
additional information
?
-
comparison of the biochemical properties to those of the enzyme from Streptomyces peucetius var. caesius
-
-
?
additional information
?
-
-
comparison of the biochemical properties to those of the enzyme from Streptomyces coelicolor
-
-
?
additional information
?
-
-
no activity with D-mannose and D-fructose as phosphoryl acceptors, no activity with UDP, ADP, acetyl phosphate, and diphosphate as phosphoryl donors
-
-
?
additional information
?
-
-
no activity with fructose, galactose, and mannose, development of a coupled assay method with glucose 6-phosphate dehydrogenase stable at pH 6.8-8.5 and 75-90°C, overview
-
-
?
additional information
?
-
-
enzyme reacts equally well with ATP, UTP, GTP, ITP and CTP
-
-
?
