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2.7.1.20: adenosine kinase

This is an abbreviated version!
For detailed information about adenosine kinase, go to the full flat file.

Word Map on EC 2.7.1.20

Reaction

ATP
+
adenosine
=
ADP
+
AMP

Synonyms

adenosine kinase (phosphorylating), ADK, AdK-L, AdK-S, Ado kinase, AdoK, AK, ATP:adenosine 5'-phosphotransferase, CpAK, hADK, kinase, adenosine (phosphorylating), LdAdK, MGG_06270, Rv2202c, Tb927.6.2360, TbAK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.20 adenosine kinase

KI Value

KI Value on EC 2.7.1.20 - adenosine kinase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0000275
(1R,2S,3R,5R)-3-(6-(4-([1,1'-biphenyl]-4-yl)piperazin-1-yl)-9H-purin-9-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol
pH 7.5, temperature not specified in the publication
0.000023
(2R,3R,4S,5R)-2-(6-(4-(4-(1-(difluoromethyl)-1H-pyrazol-4-yl)phenyl)piperazin-1-yl)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
pH 7.5, temperature not specified in the publication
0.0000053
(2R,3R,4S,5R)-2-(6-(4-([1,1'-biphenyl]-4-yl)piperazin-1-yl)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
pH 7.5, temperature not specified in the publication
0.000048
(2R,3R,4S,5R)-2-(6-([1,1'-biphenyl]-4-ylethynyl)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
pH 7.5, temperature not specified in the publication
0.0000255 - 0.00041
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-(3'-(morpholinomethyl)-[1,1'-biphenyl]-4-yl)piperazin-1-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol
0.0000189
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-(4'-(2-hydroxypropan-2-yl)-[1,1'-biphenyl]-4-yl)piperazin-1-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol
pH 7.5, temperature not specified in the publication
0.0000213
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)piperazin-1-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol
pH 7.5, temperature not specified in the publication
0.000326 - 0.0016
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-(4-(6-(trifluoromethyl)pyridin-3-yl)phenyl)piperazin-1-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol
0.0000185
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-(4-(6-methoxypyridin-3-yl)phenyl)piperazin-1-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol
pH 7.5, temperature not specified in the publication
0.0000199
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-(phenylethynyl)phenyl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol
pH 7.5, temperature not specified in the publication
0.00012 - 0.0051
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-phenylpiperazin-1-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol
0.00000006 - 0.00000009
(2S,3S,4R,5R)-2-amino-5-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol
0.01575
2'-deoxyadenosine
-
wild-type enzyme
0.15
2,4,6-trimethyl-6-benzylthioinosine
-
pH 7.4, 37°C, recombinant enzyme
0.0007
2,4-dichloro-6-benzylthioinosine
-
pH 7.4, 37°C, recombinant enzyme
0.0014
2-chloro-6-benzylthioinosine
-
pH 7.4, 37°C, recombinant enzyme
0.0377
2-chloro-6-fluoro-6-benzylthioinosine
-
pH 7.4, 37°C, recombinant enzyme
0.0005
2-fluoro-adenosine
-
0.0005
2-fluoroadenosine
0.0015
2-methyl-6-benzylthioinosine
-
pH 7.4, 37°C, recombinant enzyme
0.0004
2-Phenylethylureidopurine ribonucleoside
-
-
0.0033
3'-deoxyadenosine
-
wild-type enzyme
0.0025
3,4-dichloro-6-benzylthioinosine
-
pH 7.4, 37°C, recombinant enzyme
0.0013
3-methyl-6-benzylthioinosine
-
pH 7.4, 37°C, recombinant enzyme
0.003
3-nitro-6-benzylthioinosine
-
pH 7.4, 37°C, recombinant enzyme
0.0029
3-trifluoromethyl-6-benzylthioinosine
-
pH 7.4, 37°C, recombinant enzyme
0.096
4-acetoxy-6-benzylthioinosine
-
pH 7.4, 37°C, recombinant enzyme
0.0000014 - 0.0000017
4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine
0.0075
4-bromo-6-benzylthioinosine
-
pH 7.4, 37°C, recombinant enzyme
0.0021
4-chloro-6-benzylthioinosine
-
pH 7.4, 37°C, recombinant enzyme
0.0009
4-cyano-6-benzylthioinosine
-
pH 7.4, 37°C, recombinant enzyme
0.0012
4-fluoro-6-benzylthioinosine
-
pH 7.4, 37°C, recombinant enzyme
0.0026
4-methoxy-6-benzylthioinosine
-
pH 7.4, 37°C, recombinant enzyme
0.0033
4-methyl-6-benzylthioinosine
-
pH 7.4, 37°C, recombinant enzyme
0.0011
4-nitro-6-benzylthioinosine
-
pH 7.4, 37°C, recombinant enzyme
0.113
4-tert-butyl-6-benzylthioinosine
-
pH 7.4, 37°C, recombinant enzyme
0.141
4-trifluoromethoxy-6-benzylthioinosine
-
pH 7.4, 37°C, recombinant enzyme
0.0008
5'-amino-5'-deoxy-adenosine
-
0.0000306
5-iodotubercidin
-
-
0.0024
6-benzylthioinosine
-
pH 7.4, 37°C, recombinant enzyme
0.00015
6-cyclopentyloxypurine riboside
0.16
6-methylmercaptopurine riboside phosphate
-
pH 6.0, 37ºC
0.015
7-beta-D-ribofuranosyl-pyrrolo-(2,3-d)-pyrimidine
-
pH 6.0, 37ºC
0.00021
7-iodo-7-deazaadenosine
0.0000163
7-[4-([1,1'-biphenyl]-4-yl)piperazin-1-yl]-3-beta-D-ribofuranosyl-3H-imidazo[4,5-b]pyridine
pH 7.5, temperature not specified in the publication
0.0058
8-aza-9-deazaadenosine
0.0059 - 0.26
adenosine
0.000073 - 0.002
adenosine-5'-pentaphospho-5'-adenosine
0.00003 - 0.0004
adenosine-5'-tetraphospho-5'-adenosine
0.011 - 0.2
ADP
0.015 - 1.84
AMP
7.19
clodronate
-
-
5.36
etidronate
-
-
0.000001 - 0.00021
iodotubercidin
0.03 - 0.534
MgADP-
0.00019
N1-benzyladenosine
0.061
P1,P3-di(adenosine-5')triphosphate
-
at 27°C in 50 mM Tris buffer (pH 7.4) containing 5 mM MgCl2, 50 mM KCl, and 0.2 mM dithiothreitol
0.00086
P1,P4-di(adenosine-5')tetraphosphate
-
at 27°C in 50 mM Tris buffer (pH 7.4) containing 5 mM MgCl2, 50 mM KCl, and 0.2 mM dithiothreitol
1.95
Phosphonoacetic acid
-
recombinant enzyme, pH 7.2, 37°C
additional information
additional information
-
development of methods for analyzing the enzymatic reaction of adenosine kinase. These methods allow to measure substrates and potential inhibitors for adenosine kinase within a few min with high accuracy and reproducibility by means of capillary electrophoresis
-