2.7.1.20: adenosine kinase
This is an abbreviated version!
For detailed information about adenosine kinase, go to the full flat file.
Word Map on EC 2.7.1.20
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2.7.1.20
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nucleoside
-
deaminase
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purine
-
amp
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adenylate
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inosine
-
salvage
-
hypoxanthine
-
epilepsy
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phosphoribosyltransferase
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5'-nucleotidase
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5-iodotubercidin
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riboside
-
deoxyadenosine
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s-adenosylhomocysteine
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deoxycytidine
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aicar
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anticonvulsant
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tubercidin
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dipyridamole
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neuromodulator
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ehna
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2\'-deoxycoformycin
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ecto-5\'-nucleotidase
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ribokinase
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erythro-9-2-hydroxy-3-nonyl
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adenosinergic
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6-methylmercaptopurine
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3hadenosine
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2-chloroadenosine
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coformycin
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nitrobenzylthioinosine
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epileptogenesis
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hypoxanthine-guanine
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transmethylation
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adenosine-induced
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hgprt
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kinase-deficient
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2'-deoxyadenosine
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adenosine-mediated
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3.5.4.4
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deoxycoformycin
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non-nucleoside
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analysis
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2.4.2.8
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9-beta-d-arabinofuranosyladenine
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n6-cyclopentyladenosine
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erythro-9-2-hydroxy-3-nonyladenine
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dado
-
ara-a
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medicine
-
diagnostics
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rephosphorylation
-
pharmacology
- 2.7.1.20
- nucleoside
- deaminase
- purine
- amp
- adenylate
- inosine
-
salvage
- hypoxanthine
- epilepsy
-
phosphoribosyltransferase
- 5'-nucleotidase
- 5-iodotubercidin
- riboside
- deoxyadenosine
- s-adenosylhomocysteine
- deoxycytidine
- aicar
-
anticonvulsant
- tubercidin
- dipyridamole
-
neuromodulator
- ehna
-
2\'-deoxycoformycin
-
ecto-5\'-nucleotidase
- ribokinase
-
erythro-9-2-hydroxy-3-nonyl
-
adenosinergic
- 6-methylmercaptopurine
-
3hadenosine
- 2-chloroadenosine
- coformycin
-
nitrobenzylthioinosine
-
epileptogenesis
-
hypoxanthine-guanine
-
transmethylation
-
adenosine-induced
- hgprt
-
kinase-deficient
- 2'-deoxyadenosine
-
adenosine-mediated
-
3.5.4.4
- deoxycoformycin
-
non-nucleoside
- analysis
-
2.4.2.8
- 9-beta-d-arabinofuranosyladenine
-
n6-cyclopentyladenosine
-
erythro-9-2-hydroxy-3-nonyladenine
-
dado
- ara-a
- medicine
- diagnostics
-
rephosphorylation
- pharmacology
Reaction
Synonyms
adenosine kinase (phosphorylating), ADK, AdK-L, AdK-S, Ado kinase, AdoK, AK, ATP:adenosine 5'-phosphotransferase, CpAK, hADK, kinase, adenosine (phosphorylating), LdAdK, MGG_06270, Rv2202c, Tb927.6.2360, TbAK
ECTree
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KM Value
KM Value on EC 2.7.1.20 - adenosine kinase
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0.245
TTP
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at 27°C in 50 mM Tris buffer (pH 7.4) containing 5 mM MgCl2, 50 mM KCl, and 0.2 mM dithiothreitol
0.079
native enzyme, pH 8.0, 37°C, in presence of 10 mM KCl
0.709
2-methyladenosine
native enzyme, pH 8.0, 37°C, in absence of KCl
0.0000081
-
with ATP as cosubstrate, at 27°C in 50 mM Tris buffer (pH 7.4) containing 5 mM MgCl2, 50 mM KCl, and 0.2 mM dithiothreitol
0.00023
adenosine
-
with GTP as cosubstrate, at 27°C in 50 mM Tris buffer (pH 7.4) containing 5 mM MgCl2, 50 mM KCl, and 0.2 mM dithiothreitol
0.00063
adenosine
-
with CTP as cosubstrate, at 27°C in 50 mM Tris buffer (pH 7.4) containing 5 mM MgCl2, 50 mM KCl, and 0.2 mM dithiothreitol
0.00074
adenosine
-
with UTP as cosubstrate, at 27°C in 50 mM Tris buffer (pH 7.4) containing 5 mM MgCl2, 50 mM KCl, and 0.2 mM dithiothreitol
0.00079
adenosine
-
with TTP as cosubstrate, at 27°C in 50 mM Tris buffer (pH 7.4) containing 5 mM MgCl2, 50 mM KCl, and 0.2 mM dithiothreitol
0.0008
adenosine
native enzyme, pH 8.0, 37°C, in presence of 10 mM KCl
0.0014
adenosine
-
recombinant enzyme, pH 7.2, 37°C, in presence of 1-10 mM phosphate
0.0017
adenosine
-
recombinant enzyme, pH 7.2, 37°C, in presence of 10-20 mM creatine phosphate
0.0022
adenosine
-
recombinant enzyme, pH 7.2, 37°C, in presence of 20 mM phosphoribosyl diphosphate
0.0023
adenosine
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recombinant enzyme, pH 7.2, 37°C, in presence of 20 mM phosphoenolpyruvate
0.0032
adenosine
-
recombinant enzyme, pH 7.3, 37°C, phosphate buffered saline
0.0034
adenosine
native enzyme, pH 8.0, 37°C, in absence of KCl
0.7 - 6.4
adenosine
-
affinity increases asymptotically upon the addition of increasing phosphate from 1 to 50 mM
1.71
adenosine
pH 7.5, temperature not specified in the publication
0.0014
-
at 27°C in 50 mM Tris buffer (pH 7.4) containing 5 mM MgCl2, 50 mM KCl, and 0.2 mM dithiothreitol
0.033
ATP
-
pH 7.5, 30ºC, with adenosine and ATP saturating concentrations
0.049
-
at 27°C in 50 mM Tris buffer (pH 7.4) containing 5 mM MgCl2, 50 mM KCl, and 0.2 mM dithiothreitol
0.054
-
at 27°C in 50 mM Tris buffer (pH 7.4) containing 5 mM MgCl2, 50 mM KCl, and 0.2 mM dithiothreitol
0.54
-
recombinant enzyme, pH 7.3, 37°C, phosphate buffered saline
0.056
-
at 27°C in 50 mM Tris buffer (pH 7.4) containing 5 mM MgCl2, 50 mM KCl, and 0.2 mM dithiothreitol
7.7
-
recombinant enzyme, pH 9.0, 37°C, phosphate buffered saline
16
viramidine
-
recombinant enzyme, pH 7.3, 37°C, phosphate buffered saline
additional information
additional information
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pH and Mg/ATP ratio-dependent Km
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additional information
additional information
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removal of residues 17 to 28 from the N-terminal end of the protein leads to an increase in the Km for adenosine. Removal of the first 10 residues from the C-terminal end causes a 5fold increase in the Km for ATP
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additional information
additional information
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kinetic data of nucleosides and nucleoside analogs
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