2.7.1.21: thymidine kinase

This is an abbreviated version!
For detailed information about thymidine kinase, go to the full flat file.

Word Map on EC 2.7.1.21

2.7.1.21

herpes

simplex

ganciclovir

suicide

nucleoside

hsv-tk

acyclovir

viruses

triphosphate

adenovirus

prodrugs

salvage

lymphocyte

vaccinia

herpesvirus

pyrimidine

bystander

retroviral

chloramphenicol

positron

glioma

intratumoral

cotransfection

deoxycytidine

varicella-zoster

cytomegalovirus

tomography

nude

lymphoma

dna-mediated

dtmp

deoxynucleoside

retrovirus-mediated

oncolytic

adenovirus-mediated

gene-modified

deoxyguanosine

deoxyribonucleoside

synthesis

medicine

herpetic

diagnostics

replication-defective

neurovirulence

3hthymidine

zidovudine

kinase-deficient

molecular biology

3'-azido-3'-deoxythymidine

pseudorabies

replication-competent

varicella

zoster

5-fluorocytosine

Reaction

Synonyms

2'-deoxythymidine kinase, ATP-thymidine 5'-phosphotransferase, beta-thymidine kinase-1, beta-thymidine kinase-2, calmodulin-binding protein, CaM-binding protein, CaMBP, CHV-TK, dThd kinase-1, dThd kinase-2, EC 2.7.1.75, EHV4-TK, FHV-TK, HSV-1 TK, HSV1-TK, kinase, deoxythymidine (phosphorylating), kinase, thymidine (phosphorylating), LMJF_21_1210, mitochondrial thymidine kinase, More, Mt-TK, TdR kinase, ThyB, thymidine kinase, thymidine kinase 1, thymidine kinase 2, thymidine kinase 2, mitochondrial, thymidine kinase I, thymidine kinase-1, thymidine kinase-2, thymidylate kinase, TK, TK-1, TK-2, TK1, TK1a, TK1b, TK2, type 1 thymidine kinase, type II thymidine kinase 1, UL23, VVTK

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.21 thymidine kinase

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Results	in table
23	Activating Compound
25968	AA Sequence
17	Application
1	CAS Registry Number
58	Cloned(Commentary)
27	Cofactor
13	Crystallization (Commentary)
16075	Disease/ Diagnostics
6	Expression
17	General Information
12	General Stability
193	IC50 Value
346	Inhibitors
68	kcat/KM [mM/s]
54	Ki Value [mM]
276	KM Value [mM]
51	Localization
68	Metals/Ions
93	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
184	Organism
6	Pathway
156	PDB ID
28	pH Optimum
5	pH Range
2	pH Stability
6	pI Value
1	Posttranslational Modification
52	Protein Variants
65	Purification (Commentary)
12	Reaction
1	Reaction Type
171	Reference
1	Renatured (Commentary)
44	Source Tissue
29	Specific Activity [micromol/min/mg]
14	Storage Stability
353	Substrates and Products (Substrate)
59	Subunits
151	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Range [°C]
16	Temperature Stability [°C]
122	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 2.7.1.21 - thymidine kinase

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3'-azido-2',3'-dideoxy-3,4-dihydrothymidine

Rattus norvegicus

stimulates deoxycytidine phosphorylation catalyzed by thymidine kinase 2

723302

3'-azido-3'-deoxythymidine

Homo sapiens

stimulates deoxycytidine phosphorylation catalyzed by thymidine kinase 2

723302

3'-deoxy-3'-fluorothymidine

Homo sapiens

stimulates deoxycytidine phosphorylation catalyzed by thymidine kinase 2

723302

3'-fluorothymidine

Rattus norvegicus

stimulates deoxycytidine phosphorylation catalyzed by thymidine kinase 2

723302

ATP

2 entries

bovine serum albumin

Escherichia coli

activation at 0.2 mg/ml

641116

Calmodulin

Dictyostelium discoideum

Q27564

stimulates the enzyme by 13.8%, might modify the activity, enzyme contains a calmodulin binding domain, Ca2+ is required for binding, compounds W7 and W13 prevent stimulation, overview

dCDP

dCTP

dithiothreitol

GTP

activation

Hydroxymethyl-dCDP

activation

Hydroxymethyl-dCTP

activation

KCl

weak stimulation

NaCl

weak stimulation

potassium acetate

weak stimulation

additional information

2 entries