2.7.1.22: ribosylnicotinamide kinase
This is an abbreviated version!
For detailed information about ribosylnicotinamide kinase, go to the full flat file.
Word Map on EC 2.7.1.22
Reaction
Synonyms
kinase, ribosylnicotinamide (phosphorylating), More, muscle-specific beta1 integrin binding protein, NadR, nicotinamide ribose kinase, nicotinamide riboside kinase, nicotinamide riboside kinase 1, nicotinamide riboside kinase 2, nicotinamide riboside kinase-2, NmR-K, NMRK1, NMRK2, NR kinase 1, Nrk, NRK-2, NRK1, Nrk2, Nrk2b
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Reference on EC 2.7.1.22 - ribosylnicotinamide kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rowen, J.W.; Kornberg, A.
The phosphorolysis of nicotinamide riboside
J. Biol. Chem.
193
497-507
1951
Sus scrofa
Singh, S.K.; Kurnasov, O.V.; Chen, B.; Robinson, H.; Grishin, N.V.; Osterman, A.L.; Zhang, H.
Crystal structure of Haemophilus influenzae NadR protein. A bifunctional enzyme endowed with NMN adenyltransferase and ribosylnicotinimide kinase activities
J. Biol. Chem.
277
33291-33299
2002
Haemophilus influenzae
Kurnasov, O.V.; Polanuyer, B.M.; Ananta, S.; Sloutsky, R.; Tam, A.; Gerdes, S.Y.; Osterman, A.L.
Ribosylnicotinamide kinase domain of NadR protein: identification and implications in NAD biosynthesis
J. Bacteriol.
184
6906-6917
2002
Escherichia coli, Salmonella enterica, Haemophilus influenzae (Q57425), Haemophilus influenzae
Grose, J.H.; Bergthorsson, U.; Roth, J.R.
Regulation of NAD synthesis by the trifunctional NadR protein of Salmonella enterica
J. Bacteriol.
187
2774-2782
2005
Salmonella enterica
Belenky, P.; Racette, F.G.; Bogan, K.L.; McClure, J.M.; Smith, J.S.; Brenner, C.
Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+
Cell
129
473-484
2007
Saccharomyces cerevisiae (P53915)
Merdanovic, M.; Sauer, E.; Reidl, J.
Coupling of NAD+ biosynthesis and nicotinamide ribosyl transport: characterization of NadR ribonucleotide kinase mutants of Haemophilus influenzae
J. Bacteriol.
187
4410-4420
2005
Haemophilus influenzae
Khan, J.A.; Xiang, S.; Tong, L.
Crystal structure of human nicotinamide riboside kinase
Structure
15
1005-1013
2007
Homo sapiens (Q9NWW9), Homo sapiens
Zamporlini, F.; Ruggieri, S.; Mazzola, F.; Amici, A.; Orsomando, G.; Raffaelli, N.
Novel assay for simultaneous measurement of pyridine mononucleotides synthesizing activities allows dissection of the NAD+ biosynthetic machinery in mammalian cells
FEBS J.
281
5104-5119
2014
Homo sapiens
Ahmad, F.; Tomar, D.; Aryal A C, S.; Elmoselhi, A.B.; Thomas, M.; Elrod, J.W.; Tilley, D.G.; Force, T.
Nicotinamide riboside kinase-2 alleviates ischemia-induced heart failure through P38 signaling
Biochim. Biophys. Acta
1866
165609
2020
Mus musculus (Q9D7C9), Mus musculus, Homo sapiens (Q9NPI5), Homo sapiens, Mus musculus C57BL/6N (Q9D7C9)
Fletcher, R.S.; Ratajczak, J.; Doig, C.L.; Oakey, L.A.; Callingham, R.; Da Silva Xavier, G.; Garten, A.; Elhassan, Y.S.; Redpath, P.; Migaud, M.E.; Philp, A.; Brenner, C.; Canto, C.; Lavery, G.G.
Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells
Mol. Metab.
6
819-832
2017
Mus musculus (Q91W63), Mus musculus (Q9D7C9)
Sambeat, A.; Ratajczak, J.; Joffraud, M.; Sanchez-Garcia, J.L.; Giner, M.P.; Valsesia, A.; Giroud-Gerbetant, J.; Valera-Alberni, M.; Cercillieux, A.; Boutant, M.; Kulkarni, S.S.; Moco, S.; Canto, C.
Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage
Nat. Commun.
10
4291
2019
Mus musculus (Q91W63)
Ratajczak, J.; Joffraud, M.; Trammell, S.A.; Ras, R.; Canela, N.; Boutant, M.; Kulkarni, S.S.; Rodrigues, M.; Redpath, P.; Migaud, M.E.; Auwerx, J.; Yanes, O.; Brenner, C.; Canto, C.
NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells
Nat. Commun.
7
13103
2016
Mus musculus
Doig, C.L.; Zielinska, A.E.; Fletcher, R.S.; Oakey, L.A.; Elhassan, Y.S.; Garten, A.; Cartwright, D.; Heising, S.; Alsheri, A.; Watson, D.G.; Prehn, C.; Adamski, J.; Tennant, D.A.; Lavery, G.G.
Induction of the nicotinamide riboside kinase NAD+ salvage pathway in a model of sarcoplasmic reticulum dysfunction
Skeletal Muscle
10
5
2020
Mus musculus (Q9D7C9), Mus musculus C57/BL6J (Q9D7C9)
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