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2.7.1.24: dephospho-CoA kinase

This is an abbreviated version!
For detailed information about dephospho-CoA kinase, go to the full flat file.

Word Map on EC 2.7.1.24

Reaction

ATP
+
3'-dephospho-CoA
=
ADP
+
CoA

Synonyms

3'-dephospho-CoA kinase, CoaE, coenzyme A synthase, cytosolic monofunctional DPCK, dephospho coenzyme A kinase, dephospho-CoA kinase, dephospho-coenzyme A kinase, dephosphocoenzyme A, dephosphocoenzyme A kinase, dephosphocoenzyme A kinase (phosphorylating), DPCK, Dpck1, Dpck2, EhDPCK1, EhDPCK2, GTP-dependent dephospho-CoA kinase, GTP-dependent DPCK, kinase, dephosphocoenzyme A (phosphorylating), More, TK1697

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.24 dephospho-CoA kinase

Inhibitors

Inhibitors on EC 2.7.1.24 - dephospho-CoA kinase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
acetyl-CoA
inhibition at higher concentrations; inhibition at higher concentrations
CoA
inhibition at higher concentrations; inhibition at higher concentrations
coenzyme A
-
-
CTP
-
enzymatic activity is regulated by CTP which strongly binds the enzyme at a site overlapping that of the leading substrate, dephosphocoenzyme A, thereby obscuring the binding site and limiting catalysis. 16% residual activity at 1 mM CTP
deoxycholate
-
inactivation, 0.2%
EDC4
-
EDC4 is also known as Ge-1, Hedls, RCD-8. EDC4 strongly inhibits the dephospho-CoA kinase activity of coenzyme A synthase in vitro
-
malonyl-CoA
inhibition at higher concentrations; inhibition at higher concentrations
UTP
at high concentrations
additional information
-