2.7.1.25: adenylyl-sulfate kinase

This is an abbreviated version!
For detailed information about adenylyl-sulfate kinase, go to the full flat file.

Reaction

Synonyms

3'-phosphoadenosine 5'-phosphosulfate synthetase1, 3'-phosphoadenosine-5'-phosphosulfate synthetase, 5'-phosphoadenosine sulfate kinase, adenosine 5'-phosphosulfate kinase, adenosine 5'-phosphosulphate kinase, adenosine 5-phosphosulfate kinase, adenosine 5�-phosphosulfate kinase, adenosine phosphosulfate kinase, adenosine phosphosulfokinase, adenosine-5'-phosphosulfate 3'-phosphotransferase, adenosine-5'-phosphosulfate kinase, adenosine-5'-phosphosulfate-3'-phosphokinase, adenosine-5'phosphosulfate kinase, adenosine-5�-phosphosulfate kinase, adenylyl-sulfate kinase, adenylylsulfate 3'-phosphotransferase, adenylylsulfate kinase, adenylylsulphate kinase, APK, APK1, APK2, APK3, APK4, APS kinase, APS-kinase, APSK, APSK1, ATP adenosine-5'-phosphosulfate 3'-phosphotransferase, ATP sulfurylase-APS kinase, CysC, EhAPSK, EHI_179080, kinase, adenylylsulfate (phosphorylating), MgATP:APS 3'-phosphotransferase, More, MXAN3487, MXAN_3487, MXAN_RS16905, PAPS 2, PAPS synthase, PAPS synthetase, PAPSS, PAPSS 1, PAPSS1

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.25 adenylyl-sulfate kinase

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Results	in table
24	Activating Compound
26932	AA Sequence
1	CAS Registry Number
27	Cloned(Commentary)
12	Crystallization (Commentary)
75	Disease/ Diagnostics
4	Expression
16	General Information
8	General Stability
17	IC50 Value
88	Inhibitors
13	kcat/KM [mM/s]
19	Ki Value [mM]
72	KM Value [mM]
10	Localization
37	Metals/Ions
39	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
74	Organism
1	Oxidation Stability
8	Pathway
75	PDB ID
22	pH Optimum
8	pH Range
2	pH Stability
1	Posttranslational Modification
57	Protein Variants
32	Purification (Commentary)
6	Reaction
1	Reaction Type
69	Reference
46	Source Tissue
15	Specific Activity [micromol/min/mg]
4	Storage Stability
97	Substrates and Products (Substrate)
32	Subunits
76	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
15	Temperature Stability [°C]
23	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.7.1.25 - adenylyl-sulfate kinase

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SYSTEMATIC NAME

IUBMB Comments

ATP:adenylyl-sulfate 3'-phosphotransferase

The human phosphoadenosine-phosphosulfate synthase (PAPSS) system is a bifunctional enzyme (fusion product of two catalytic activities). In a first step, sulfate adenylyltransferase catalyses the formation of adenosine 5'-phosphosulfate (APS) from ATP and inorganic sulfate. The second step is catalysed by the adenylylsulfate kinase portion of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase, which involves the formation of PAPS from enzyme-bound APS and ATP. In contrast, in bacteria, yeast, fungi and plants, the formation of PAPS is carried out by two individual polypeptides, sulfate adenylyltransferase (EC 2.7.7.4) and adenylyl-sulfate kinase (EC 2.7.1.25).