2.7.1.3: ketohexokinase

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For detailed information about ketohexokinase, go to the full flat file.

Word Map on EC 2.7.1.3

2.7.1.3

fructokinase

fructose-induced

high-fructose

fructose-1-phosphate

triokinase

fructolytic

fructosuria

fructose-metabolizing

medicine

analysis

Reaction

Synonyms

ATP:D-fructose 1-phosphotransferase, fructokinase, ketohexokinase, ketohexokinase (phosphorylating), KHK, Khk-A, Khk-C

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.3 ketohexokinase

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Results	in table
47	AA Sequence
3	Application
1	CAS Registry Number
6	Cloned(Commentary)
4	Crystallization (Commentary)
79	Disease/ Diagnostics
11	General Information
2	General Stability
63	IC50 Value
99	Inhibitors
2	Ki Value [mM]
55	KM Value [mM]
26	Metals/Ions
9	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
36	Organism
4	Pathway
51	PDB ID
5	pH Optimum
2	pH Range
3	pI Value
3	Protein Variants
8	Purification (Commentary)
2	Reaction
1	Reaction Type
35	Reference
57	Source Tissue
9	Specific Activity [micromol/min/mg]
2	Storage Stability
70	Substrates and Products (Substrate)
4	Subunits
29	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
12	Turnover Number [1/s]

Source Tissue

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Source Tissue on EC 2.7.1.3 - ketohexokinase

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bone

Homo sapiens

relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues

relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues

678985

chorion

Sus scrofa

ketohexokinase protein is detected in the trophectoderm at day 11 of pregnancy

expressed at significantly higher level in glioma tissues than in non-tumor brain

hepatocellular carcinoma cell

739133

ileum

Rattus norvegicus

12.4% of the phosphorylation of D-fructose by ileum homogenates is attributable to ketohexokinase

relatively high expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues

renal cell carcinoma cell

Homo sapiens

P50053

represent the most prevalent cancer of the kidney. The mean ketohexokinase activity in the renal cell carcinoma tissue samples is approximately 1.4fold lower than that in their normal kidney tissue. Ketohexokinase activity is approximately 1.5fold lower in pT3 renal cell carcinoma tissue than that in pT1 renal cell carcinoma tissue. The enzyme activity of tumor in histological grade 3 is 1.8fold lower than for grade 1 tumor(reaction mixture activity assay: acid-treated supernatant (100 microl) containing 10 mM MgCl2, 50 mM TrisHCl, pH 7.4, 10 mM ATP, 50 mM N-acetyl-D-glucosamine, 10 mM D[UL-14C]fructose and water, at 37°C). The expression level of ketohexokinase mRNA is reduced two- to eightfold in nearly all the clear cell renal cell carcinoma tissue samples compared with normal kidney, except for one renal cell carcinoma sample.

relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues

ketohexokinase protein is detected at all stages of gestation studied through day 85

758874

uterine endometrium

Sus scrofa

expression of ketohexokinase mRNA is greater from day 9 through 17 of pregnancy compared to the corresponding days of the estrous cycle. There is an increase in expression of KHK mRNA through day 85, with peaks at days 30 and 85. Ketohexokinase protein is only detectable in GE of the endometrium at day 30 of pregnancy

758874

additional information

5 entries