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2.7.1.30: glycerol kinase

This is an abbreviated version!
For detailed information about glycerol kinase, go to the full flat file.

Word Map on EC 2.7.1.30

Reaction

ATP
+
glycerol
=
ADP
 +
sn-glycerol 3-phosphate

Synonyms

AFUB_068560, ASTP , ATP-stimulated glucocorticoid-receptor translocation promoter , ATP: glycerol 3-phosphotransferase, ATP: glycerol-3-phosphotransferase, ATP:glycerol 3-phosphotransferase, ATP:glycerol 3-phosphotransferase , ATP:glycerol-3-phosphotransferase, GK, GK1, GK2, GK3, GK4, GK5, glcA, GLPK, glyceric kinase, glycerokinase, glycerol kinase, glycerol kinase 2, glycerol kinase 5, GLYK, GUT1, GYK, kinase, glycerol (phosphorylating), KpGlpK, More, slr1672, TbgGK, Tk-GK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.30 glycerol kinase

Source Tissue

Source Tissue on EC 2.7.1.30 - glycerol kinase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
lung cell line
Manually annotated by BRENDA team
-
There is no difference in glycerol mRNA level between control 3T3-L1 adipocytes and 3T3-L1 Aqp7-RNAi transfected adipocytes, whereas a 4fold enzymatic activation of glycerol kinase is observable in Aqp7 knockout adipocytes (activity assay: 50 mM TrisHCl, pH 7.2, 5 mM ATP, 10 mM MgCl2, 100 mM KCl, 2.5 mM DTT, 4 mM glycerol, 500 microM 3H-glycerol, for 90 min at 37°C).
Manually annotated by BRENDA team
-
SS6-2 cell, stem cells from fat with myotube characteristics
Manually annotated by BRENDA team
-
Aqp7-/- knockout mice have significantly lower plasma glycerol level under 12 h fasting conditions.
Manually annotated by BRENDA team
-
newborn, expresses only isoform GK-EX18
Manually annotated by BRENDA team
-
from patients with enzyme deficiency and normal individuals
Manually annotated by BRENDA team
-
kidney cell line
Manually annotated by BRENDA team
-
kidney cell line, expresses only isoform GK+EX18
Manually annotated by BRENDA team
-
adult hepatoblastoma cell line
Manually annotated by BRENDA team
Candida mycoderma
-
-
Manually annotated by BRENDA team
-
pancreatic islets and pancreas. The glycerol kinase mRNA level in the Aqp7-/- pancreatic islets is 655% that in Aqp7+/+ islets. The glycerol activity is increased in both total pancreases and islets isolated from Aqp7-/- mice compared with those isolated from Aqp+/+ mice (tested with cell homogenates, activity assay: 50 mM Tris-HCl, pH 7.2, 5 mM ATP, 10 mM MgCl2, 100 mM KCl, 2.5 mM dithiothreitol, 4 mM glycerol, 50 microM [14C]glycerol, for 3 h at 37°C). The absence of AQP7 is associated with a moderate increase in the glycerol content of the total pancreas. There is a 2fold increase in the glycerol content of pancreatic islets isolated from Aqp7-/- mice compared with those from Aqp7+/+ mice.
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
fetal liver cell line
Manually annotated by BRENDA team
additional information