2.7.1.33: pantothenate kinase
This is an abbreviated version!
For detailed information about pantothenate kinase, go to the full flat file.
Word Map on EC 2.7.1.33
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2.7.1.33
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neurodegeneration
-
kinase-associated
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panks
-
sign
-
dystonia
-
ganglia
-
hallervorden-spatz
-
extrapyramidal
-
parkinsonism
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eye-of-the-tiger
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pla2g6
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phosphopantothenate
-
dysarthria
-
tiger
-
neuroaxonal
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phosphopantetheine
-
hypointensity
-
medicine
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4'-phosphopantothenate
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pigmentary
-
pantothenamide
-
bradykinesia
-
synthesis
-
atp13a2
-
4'-phosphopantetheine
-
pantethine
-
drug development
-
neuroferritinopathy
-
choreoathetosis
-
phosphopantothenoylcysteine
- 2.7.1.33
- neurodegeneration
-
kinase-associated
-
panks
- sign
- dystonia
- ganglia
- hallervorden-spatz
-
extrapyramidal
- parkinsonism
-
eye-of-the-tiger
- pla2g6
- phosphopantothenate
- dysarthria
- tiger
-
neuroaxonal
- phosphopantetheine
-
hypointensity
- medicine
- 4'-phosphopantothenate
-
pigmentary
- pantothenamide
-
bradykinesia
- synthesis
-
atp13a2
- 4'-phosphopantetheine
- pantethine
- drug development
-
neuroferritinopathy
-
choreoathetosis
-
phosphopantothenoylcysteine
Reaction
Synonyms
4-phosphopantoate, BaPanK, Cab1, Cab1p, CoaA, coaW, CoaX, D-pantothenate kinase, EhPAnK, fumble, hPanK, hPanK1, hPANK2, hPanK3, hPanK4, HpPanK-III, HsPANK3, HsPANK4, kinase, pantothenate (phosphorylating), More, mPank, mPank1, mPanK2, mPanK3, MtCoaA, MtPanK, PAK, PanK, PanK-III, PanK1, PanK1alpha, PanK1b, PanK2, PanK3, PanK4, PanKBa, pantothenate kinase, pantothenate kinase 1, pantothenate kinase 2, pantothenate kinase 3, pantothenate kinase 4, pantothenate kinase-2, pantothenic acid kinase, PfPanK, Pfpank1, PoK, rPanK4, Rts protein
ECTree
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IC50 Value
IC50 Value on EC 2.7.1.33 - pantothenate kinase
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0.2
(2E)-3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]prop-2-enoic acid
Plasmodium falciparum
above, pH and temperature not specified in the publication
0.1
(2E)-3-[[(2S)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]prop-2-enoic acid
Plasmodium falciparum
above, pH and temperature not specified in the publication
0.036
(2Z)-3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]prop-2-enoic acid
Plasmodium falciparum
pH and temperature not specified in the publication
0.1
(2Z)-3-[[(2S)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]prop-2-enoic acid
Plasmodium falciparum
above, pH and temperature not specified in the publication
0.0084
1,4-dioxa-8-azaspiro[4.5]dec-8-yl[2-[(3-fluorophenyl)sulfanyl]pyridin-4-yl]methanone
Mycobacterium tuberculosis
-
in 50 mM PIPES-NaOH (pH 7.0), 25 mM KCl, 20 mM MgCl, at 25°C
0.0004
1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea dihydrobromide
Homo sapiens
isoform PanK3, at pH 7.5 and 37°C
0.00257
2-[2-(1-benzoylpiperidin-4-yl)-5-methyl-1,3-thiazol-4-yl]-N-(4-methylphenyl)acetamide
Mycobacterium tuberculosis
-
in 50 mM PIPES-NaOH (pH 7.0), 25 mM KCl, 20 mM MgCl, at 25°C
0.05 - 0.15
4-(2,4-dihydroxy-3,3-dimethylbutylamido)butyric acid
Mus musculus
-
competitive inhibitor, IC50: 0.05-0.15 mM
0.089
benzyl (2E)-3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]prop-2-enoate
Plasmodium falciparum
pH and temperature not specified in the publication
0.1
benzyl (2E)-3-[[(2S)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]prop-2-enoate
Plasmodium falciparum
above, pH and temperature not specified in the publication
0.013
benzyl (2Z)-3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]prop-2-enoate
Plasmodium falciparum
pH and temperature not specified in the publication
0.1
benzyl (2Z)-3-[[(2S)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]prop-2-enoate
Plasmodium falciparum
above, pH and temperature not specified in the publication
0.093
ethyl (2E)-2-methyl-3-[[(4R)-2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl]amino]prop-2-enoate
Plasmodium falciparum
pH and temperature not specified in the publication
0.181
ethyl (2E)-3-(2-oxoazepan-1-yl)prop-2-enoate
Plasmodium falciparum
pH and temperature not specified in the publication
0.093
ethyl (2E)-3-(2-oxoazocan-1-yl)prop-2-enoate
Plasmodium falciparum
pH and temperature not specified in the publication
0.061
ethyl (2E)-3-(2-oxoazonan-1-yl)prop-2-enoate
Plasmodium falciparum
pH and temperature not specified in the publication
0.12
ethyl (2E)-3-benzamido-2-methylprop-2-enoate
Plasmodium falciparum
pH and temperature not specified in the publication
0.158
ethyl (2E)-3-benzamidoprop-2-enoate
Plasmodium falciparum
pH and temperature not specified in the publication
0.2
ethyl (2E)-3-[(pyridine-3-carbonyl)amino]prop-2-enoate
Plasmodium falciparum
above, pH and temperature not specified in the publication
0.2
ethyl (2E)-3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]-2-methylprop-2-enoate
Plasmodium falciparum
above, pH and temperature not specified in the publication
0.1
ethyl (2E)-3-[[(2S)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]prop-2-enoate
Plasmodium falciparum
above, pH and temperature not specified in the publication
0.144
ethyl (2E)-3-[[(4R)-2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl]amino]prop-2-enoate
Plasmodium falciparum
pH and temperature not specified in the publication
0.159
ethyl (2Z)-3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]prop-2-enoate
Plasmodium falciparum
pH and temperature not specified in the publication
0.1
ethyl (2Z)-3-[[(2S)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]prop-2-enoate
Plasmodium falciparum
above, pH and temperature not specified in the publication
0.2
methyl (2E)-3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]prop-2-enoate
Plasmodium falciparum
above, pH and temperature not specified in the publication
0.1
methyl (2E)-3-[[(2S)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]prop-2-enoate
Plasmodium falciparum
above, pH and temperature not specified in the publication
0.2
methyl (2Z)-3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]prop-2-enoate
Plasmodium falciparum
above, pH and temperature not specified in the publication
0.1
methyl (2Z)-3-[[(2S)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]prop-2-enoate
Plasmodium falciparum
above, pH and temperature not specified in the publication
0.02
N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)pantothenamide
Staphylococcus aureus
A0A167Z3Z6
pH 7.6, 25°C
0.00046
N-(benzo[d][1,3]dioxol-5-ylmethyl)pantothenamide
Staphylococcus aureus
A0A167Z3Z6
pH 7.6, 25°C
0.00007
N-[1-(5-[[2-(4-chlorophenoxy)ethyl]sulfanyl]-4-methyl-4H-1,2,4-triazol-3-yl)ethyl]naphthalene-1-carboxamide
Mycobacterium tuberculosis
-
in 50 mM PIPES-NaOH (pH 7.0), 25 mM KCl, 20 mM MgCl, at 25°C
0.0004 - 0.0016
pantothenamide, N-substituted
Staphylococcus aureus
-
IC50 about 0.0004-0.0016 mM
-
0.039
tert-butyl (2E)-3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]prop-2-enoate
Plasmodium falciparum
pH and temperature not specified in the publication
0.1
tert-butyl (2E)-3-[[(2S)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]prop-2-enoate
Plasmodium falciparum
above, pH and temperature not specified in the publication
0.042
tert-butyl (2Z)-3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]prop-2-enoate
Plasmodium falciparum
pH and temperature not specified in the publication
0.1
tert-butyl (2Z)-3-[[(2S)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]prop-2-enoate
Plasmodium falciparum
above, pH and temperature not specified in the publication
0.00024 - 0.00042
[2-[(3-chlorophenyl)sulfanyl]pyridin-4-yl][4-(hydroxymethyl)piperidin-1-yl]methanone
0.00087
[2-[(3-chlorophenyl)sulfanyl]quinolin-4-yl](piperidin-1-yl)methanone
Mycobacterium tuberculosis
-
in 50 mM PIPES-NaOH (pH 7.0), 25 mM KCl, 20 mM MgCl, at 25°C
0.00082
[[2-[[4-(6-methylpyridin-2-yl)piperazin-1-yl]methyl]-4'-(trifluoromethoxy)biphenyl-4-yl]oxy]acetic acid
Mycobacterium tuberculosis
-
in 50 mM PIPES-NaOH (pH 7.0), 25 mM KCl, 20 mM MgCl, at 25°C
0.00006
Homo sapiens
IC50: 60 nM, competitive inhibitor with respect to ATP
0.159
Plasmodium falciparum
pH and temperature not specified in the publication
0.2
ethyl (2E)-3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]prop-2-enoate
Plasmodium falciparum
above, pH and temperature not specified in the publication
0.0048
Staphylococcus aureus
-
IC50 is 0.0048 mM, potent growth inhibitory anti-metabolite
0.0035
Staphylococcus aureus
-
IC50 is 0.0035 mM, has antimicrobial activity against Staphylococcus aureus
0.00024
Mycobacterium tuberculosis
-
in 50 mM PIPES-NaOH (pH 7.0), 25 mM KCl, 20 mM MgCl, at 25°C
0.00042
[2-[(3-chlorophenyl)sulfanyl]pyridin-4-yl][4-(hydroxymethyl)piperidin-1-yl]methanone
Mycobacterium tuberculosis
-
in 50 mM PIPES-NaOH (pH 7.0), 25 mM KCl, 20 mM MgCl, at 25°C