2.7.1.33: pantothenate kinase
This is an abbreviated version!
For detailed information about pantothenate kinase, go to the full flat file.
Word Map on EC 2.7.1.33
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2.7.1.33
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neurodegeneration
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kinase-associated
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panks
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sign
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dystonia
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ganglia
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hallervorden-spatz
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extrapyramidal
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parkinsonism
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eye-of-the-tiger
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pla2g6
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phosphopantothenate
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dysarthria
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tiger
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neuroaxonal
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phosphopantetheine
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hypointensity
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medicine
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4'-phosphopantothenate
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pigmentary
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pantothenamide
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bradykinesia
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synthesis
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atp13a2
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4'-phosphopantetheine
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pantethine
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drug development
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neuroferritinopathy
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choreoathetosis
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phosphopantothenoylcysteine
- 2.7.1.33
- neurodegeneration
-
kinase-associated
-
panks
- sign
- dystonia
- ganglia
- hallervorden-spatz
-
extrapyramidal
- parkinsonism
-
eye-of-the-tiger
- pla2g6
- phosphopantothenate
- dysarthria
- tiger
-
neuroaxonal
- phosphopantetheine
-
hypointensity
- medicine
- 4'-phosphopantothenate
-
pigmentary
- pantothenamide
-
bradykinesia
- synthesis
-
atp13a2
- 4'-phosphopantetheine
- pantethine
- drug development
-
neuroferritinopathy
-
choreoathetosis
-
phosphopantothenoylcysteine
Reaction
Synonyms
4-phosphopantoate, BaPanK, Cab1, Cab1p, CoaA, coaW, CoaX, D-pantothenate kinase, EhPAnK, fumble, hPanK, hPanK1, hPANK2, hPanK3, hPanK4, HpPanK-III, HsPANK3, HsPANK4, kinase, pantothenate (phosphorylating), More, mPank, mPank1, mPanK2, mPanK3, MtCoaA, MtPanK, PAK, PanK, PanK-III, PanK1, PanK1alpha, PanK1b, PanK2, PanK3, PanK4, PanKBa, pantothenate kinase, pantothenate kinase 1, pantothenate kinase 2, pantothenate kinase 3, pantothenate kinase 4, pantothenate kinase-2, pantothenic acid kinase, PfPanK, Pfpank1, PoK, rPanK4, Rts protein
ECTree
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Metals Ions
Metals Ions on EC 2.7.1.33 - pantothenate kinase
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Co2+
K+
KCl
Mg2+
Mn2+
NH4+
Rb+
Zn2+
additional information
Mg2+
coordinated by the nucleotide beta- and gamma-phosphates and the side chains of Ser102 and Glu199, required for ATP but not for ADP binding
Mn2+
addition (1 mM) instead of Mg2+ accelerates activity 1.75fold
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no activation by Ca2+, Cd2+, Ba2+, Pb2+, Fe2+ or Cu2+
additional information
EhPanK shows an absolute requirement for a free bivalent metal cofactor, with Mg2+ as the preferred cation. No activity with Ni2+, Na+, and K+
additional information
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EhPanK shows an absolute requirement for a free bivalent metal cofactor, with Mg2+ as the preferred cation. No activity with Ni2+, Na+, and K+
additional information
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nonspecific activation by anions in triethanolamine buffer, pH 7, mostly dicarboxylic acids, not citrate or diphosphate