2.7.1.33: pantothenate kinase
This is an abbreviated version!
For detailed information about pantothenate kinase, go to the full flat file.
Word Map on EC 2.7.1.33
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2.7.1.33
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neurodegeneration
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kinase-associated
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panks
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sign
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dystonia
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ganglia
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hallervorden-spatz
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extrapyramidal
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parkinsonism
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eye-of-the-tiger
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pla2g6
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phosphopantothenate
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dysarthria
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tiger
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neuroaxonal
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phosphopantetheine
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hypointensity
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medicine
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4'-phosphopantothenate
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pigmentary
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pantothenamide
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bradykinesia
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synthesis
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atp13a2
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4'-phosphopantetheine
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pantethine
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drug development
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neuroferritinopathy
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choreoathetosis
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phosphopantothenoylcysteine
- 2.7.1.33
- neurodegeneration
-
kinase-associated
-
panks
- sign
- dystonia
- ganglia
- hallervorden-spatz
-
extrapyramidal
- parkinsonism
-
eye-of-the-tiger
- pla2g6
- phosphopantothenate
- dysarthria
- tiger
-
neuroaxonal
- phosphopantetheine
-
hypointensity
- medicine
- 4'-phosphopantothenate
-
pigmentary
- pantothenamide
-
bradykinesia
- synthesis
-
atp13a2
- 4'-phosphopantetheine
- pantethine
- drug development
-
neuroferritinopathy
-
choreoathetosis
-
phosphopantothenoylcysteine
Reaction
Synonyms
4-phosphopantoate, BaPanK, Cab1, Cab1p, CoaA, coaW, CoaX, D-pantothenate kinase, EhPAnK, fumble, hPanK, hPanK1, hPANK2, hPanK3, hPanK4, HpPanK-III, HsPANK3, HsPANK4, kinase, pantothenate (phosphorylating), More, mPank, mPank1, mPanK2, mPanK3, MtCoaA, MtPanK, PAK, PanK, PanK-III, PanK1, PanK1alpha, PanK1b, PanK2, PanK3, PanK4, PanKBa, pantothenate kinase, pantothenate kinase 1, pantothenate kinase 2, pantothenate kinase 3, pantothenate kinase 4, pantothenate kinase-2, pantothenic acid kinase, PfPanK, Pfpank1, PoK, rPanK4, Rts protein
ECTree
2.7.1.33 pantothenate kinaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.7.1.33 - pantothenate kinase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + (R)-4-phosphopantoate + beta-alanine
AMP + diphosphate + (R)-4'-phosphopantothenate
the enzyme is involved in coenzyme A biosynthesis in the archaea
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-
?
ATP + pantothenate
ADP + (R)-4'-phosphopantothenate
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first step of the pathway from pantothenate to CoA. The activity of this protein is tightly regulated by CoA feedback inhibition, both in vitro and in vivo
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-
?
ATP + pantothenate
ADP + 4'-phosphopantothenate
pantothenate kinase catalyzes the first step in CoA biosynthesis
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-
?
dATP + (R)-pantothenate
dADP + (R)-4'-phosphopantothenate
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-
-
?
polyphosphate(n) + (R)-pantothenate
polyphosphate(n-1) + (R)-4'-phosphopantothenate
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-
-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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first step in coenzyme A biosynthesis
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-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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coaX is essential for growth of Bacillus anthracis
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-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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first step in coenzyme A biosynthesis
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-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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first step in coenzyme A biosynthesis
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-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
first step in coenzyme A biosynthesis, the enzyme has a regulatory function in the pathway
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-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
first step in coenzyme A biosynthesis
-
-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
-
-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
first step in coenzyme A biosynthesis
-
-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
-
-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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-
-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
first step in coenzyme A biosynthesis
-
-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
first step in coenzyme A biosynthesis, regulatory function
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-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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-
-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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-
-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
first step in coenzyme A biosynthesis
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-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
-
-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
first step in coenzyme A biosynthesis
-
-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
-
-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
-
-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
first step in coenzyme A biosynthesis
-
-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
-
-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
-
-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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-
-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
A0A167Z3Z6
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-
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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first step in coenzyme A biosynthesis
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-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
-
-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
first step in coenzyme A biosynthesis
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-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
A0A167Z3Z6
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-
-
?
ATP + D-pantothenate
ADP + D-4'-phosphopantothenate
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first and rate-controlling reaction of CoA-biosynthesis
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?
ATP + D-pantothenate
ADP + D-4'-phosphopantothenate
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first and rate-controlling reaction of CoA-biosynthesis
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-
?
ATP + D-pantothenate
ADP + D-4'-phosphopantothenate
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-
-
-
?
ATP + N-heptylpantothenamide
ADP + N-heptylpantothenamide 4-phosphate
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substrate is converted to the inactive butyldethia-CoA analogue in the further downstream pathway leading to grwoth inhibition of the organism, overview
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-
?
ATP + N-heptylpantothenamide
ADP + N-heptylpantothenamide 4-phosphate
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substrate is converted to the inactive butyldethia-CoA analogue in the further downstream pathway leading to grwoth inhibition of the organism, overview
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-
?
GTP + (R)-pantothenate
GDP + (R)-4'-phosphopantothenate
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-
-
?
GTP + (R)-pantothenate
GDP + (R)-4'-phosphopantothenate
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-
-
?
GTP + (R)-pantothenate
GDP + (R)-4'-phosphopantothenate
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-
-
?
additional information
?
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type III PanK in the spore-forming Bacillus anthracis plays an essential role in the novel thiol/disulfide redox biology of this category A biodefense pathogen
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?
additional information
?
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type III PanK in the spore-forming Bacillus anthracis plays an essential role in the novel thiol/disulfide redox biology of this category A biodefense pathogen
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?
additional information
?
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naturally occuring pantothenate kinase 2 mutant in patients with neurodegenerative disease in brain with iron accumulation, formerly termed Hallervorden-Spatz disease
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-
?
additional information
?
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naturally occuring pantothenate kinase 2 mutant in patients with neurodegenerative disease in brain with iron accumulation, formerly termed Hallervorden-Spatz disease
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-
?
additional information
?
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naturally occuring pantothenate kinase 2 mutant in patients with neurodegenerative disease in brain with iron accumulation, formerly termed Hallervorden-Spatz disease
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-
?
additional information
?
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miRNAs, which exist in vertebrate genomes within introns of the pantothenate kinase genes, are predicted by bioinformatics to affect multiple mRNA targets in pathways that involve cellular acetyl-CoA and lipid levels. Significantly, PANK enzymes also affect these pathways, so the miRNA and host gene may act synergistically. These predictions require experimental verification
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?
additional information
?
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pantothenate kinase is upregulated in the warming treatment
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?
