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2.7.1.33: pantothenate kinase

This is an abbreviated version!
For detailed information about pantothenate kinase, go to the full flat file.

Word Map on EC 2.7.1.33

Reaction

ATP
+
(R)-pantothenate
=
ADP
 +
(R)-4'-phosphopantothenate

Synonyms

4-phosphopantoate, BaPanK, Cab1, Cab1p, CoaA, coaW, CoaX, D-pantothenate kinase, EhPAnK, fumble, hPanK, hPanK1, hPANK2, hPanK3, hPanK4, HpPanK-III, HsPANK3, HsPANK4, kinase, pantothenate (phosphorylating), More, mPank, mPank1, mPanK2, mPanK3, MtCoaA, MtPanK, PAK, PanK, PanK-III, PanK1, PanK1alpha, PanK1b, PanK2, PanK3, PanK4, PanKBa, pantothenate kinase, pantothenate kinase 1, pantothenate kinase 2, pantothenate kinase 3, pantothenate kinase 4, pantothenate kinase-2, pantothenic acid kinase, PfPanK, Pfpank1, PoK, rPanK4, Rts protein , Rv1092c, TK2141, TmPanK-III, type II pantothenate kinase, type III pantothenate kinase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.33 pantothenate kinase

Temperature Stability

Temperature Stability on EC 2.7.1.33 - pantothenate kinase

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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
-
10% to 20% loss of activity within 10 min at pH 7.5 to 8, 10 min stable at pH 7, t1/2: 10 min at pH 6.5
35.7
Tm of enzyme mutant F254A without CoA
36.7
Tm of enzyme mutant F247A/F254A without CoA
42.4
Tm of enzyme mutant F247A with 0.2 mM CoA
43
-
10 min, inactivation
43.8
Tm of wild-type enzyme without CoA
47
-
loses kinase activity at temperatures higher than 47°C
50.1
Tm of wild-type enzyme with 0.2 mM CoA
80
purified recombinant enzyme, 10 min, pH 8.0, inactivation