2.7.1.35: pyridoxal kinase

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For detailed information about pyridoxal kinase, go to the full flat file.

Word Map on EC 2.7.1.35

2.7.1.35

5'-phosphate

vitamers

pyridoxal-5'-phosphate

plp-dependent

4-pyridoxic

ribokinase

agriculture

synthesis

drug development

medicine

Reaction

Synonyms

ePL kinase, ePL kinase 1, hPL kinase, HPLK, kinase (phosphorylating), pyridoxal, kinase, pyridoxal (phosphorylating), LdPdxK, PdxK, pdxY, PKH, PL kinase, PLK, Plk1, PM kinase, PN kinase, PN/PL/PM kinase, pyridoxal 5-phosphate-kinase, pyridoxal kinase, pyridoxal kinase 1, pyridoxal kinase PKL, pyridoxal kinase-like protein SOS4, pyridoxal phosphokinase, pyridoxal/pyridoxine kinase, pyridoxamine kinase, pyridoxine kinase, pyridoxine/pyridoxal/pyridoxamine kinase, salt overly sensitive4, SAV0580, Sos4, StPLK, vitamin B6 kinase

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.35 pyridoxal kinase

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Results	in table
4	Activating Compound
18327	AA Sequence
6	Application
1	CAS Registry Number
32	Cloned(Commentary)
10	Cofactor
18	Crystallization (Commentary)
88	Disease/ Diagnostics
1	Expression
25	General Information
5	General Stability
5	IC50 Value
129	Inhibitors
26	kcat/KM [mM/s]
16	Ki Value [mM]
122	KM Value [mM]
6	Localization
96	Metals/Ions
25	Molecular Weight [Da]
40	Natural Substrates/ Products (Substrates)
137	Organism
7	Pathway
98	PDB ID
22	pH Optimum
6	pH Range
1	pH Stability
6	pI Value
26	Protein Variants
45	Purification (Commentary)
2	Reaction
1	Reaction Type
94	Reference
1	Renatured (Commentary)
54	Source Tissue
29	Specific Activity [micromol/min/mg]
4	Storage Stability
191	Substrates and Products (Substrate)
32	Subunits
67	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
2	Temperature Range [°C]
3	Temperature Stability [°C]
69	Turnover Number [1/s]

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Application on EC 2.7.1.35 - pyridoxal kinase

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agriculture

Arabidopsis thaliana

Q8W1X2

plants lacking enzyme activity display chlorosis and reduced plant size, and hypersensitivity to NaCl and sucrose. Mutant has higher level of pyridoxine, pyridoxamine, and pyridoxal 5'-phosphate. Mutant shows higher activity of pyridoxine/pyridoxamine 5'-phosphate oxidase as well as of the vitamin B6 de novo pathway enzyme Pdx1 and increased total vitamin B6 levels

drug development

medicine

synthesis

production of cadaverine (1,5-diaminopentane) can be done by fermentation or direct bioconversion and plays an important role as a building block of polyamides. Lysine decarboxylase (CadA) transforms L-lysine to cadaverine and pyridoxal 5'-phosphate (PLP) can increase the conversion rate and yield as a cofactor. Biotransformation of cadaverine using whole Escherichia coli cells that overexpress lysine decarboxylase has many merits, such as the rapid conversion of L-lysine to cadaverine, possible application of high concentration reactions up to the molar level, production of less byproduct, and potential reuse of the enzyme by immobilization. But the supply of PLP, an essential cofactor of lysine decarboxylase, is the major bottleneck in this system. Among various PLP systems examined, pyridoxal kinase (PdxY) shows the highest conversion of PL to PLP, resulting in more than 60 % conversion of L-lysine to cadaverine with lysine decarboxylase. Method evaluation and optimization. Interconversion of interconvertion of pyridoxal and pyridoxamine has to be controlled

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