2.7.1.35: pyridoxal kinase
This is an abbreviated version!
For detailed information about pyridoxal kinase, go to the full flat file.
Word Map on EC 2.7.1.35
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2.7.1.35
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5'-phosphate
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vitamers
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pyridoxal-5'-phosphate
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plp-dependent
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4-pyridoxic
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ribokinase
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agriculture
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synthesis
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drug development
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medicine
- 2.7.1.35
- 5'-phosphate
-
vitamers
- pyridoxal-5'-phosphate
-
plp-dependent
-
4-pyridoxic
- ribokinase
- agriculture
- synthesis
- drug development
- medicine
Reaction
Synonyms
ePL kinase, ePL kinase 1, hPL kinase, HPLK, kinase (phosphorylating), pyridoxal, kinase, pyridoxal (phosphorylating), LdPdxK, PdxK, pdxY, PKH, PL kinase, PLK, Plk1, PM kinase, PN kinase, PN/PL/PM kinase, pyridoxal 5-phosphate-kinase, pyridoxal kinase, pyridoxal kinase 1, pyridoxal kinase PKL, pyridoxal kinase-like protein SOS4, pyridoxal phosphokinase, pyridoxal/pyridoxine kinase, pyridoxamine kinase, pyridoxine kinase, pyridoxine/pyridoxal/pyridoxamine kinase, salt overly sensitive4, SAV0580, Sos4, StPLK, vitamin B6 kinase
ECTree
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Inhibitors
Inhibitors on EC 2.7.1.35 - pyridoxal kinase
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4'-O-methylpyridoxine
i.e. ginkgotoxin. Treatment leads to temporarily reduced pyridoxal phosphate formation in vitro and possibly in vivo
5-dimethylaminonaphthalene-1-sulfonyl-4-aminobutyrate
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competitive with respect to pyridoxal
5-hydroxytryptamine
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0.5 mM, 11% inhibition of activity with pyridoxine, 81% inhibition of activity with pyridoxal
ADP
at high concentrations, product inhibition
cycloserine
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0.1 mM, inhibits activity with pyridoxal, but not with pyridoxamine as substrate, 42% inhibition
D-penicillamine
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0.1 mM, inhibits activity with pyridoxal, but not with pyridoxamine as substrate, 20% inhibition
isoniazid
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0.1 mM, inhibits activity with pyridoxal, but not with pyridoxamine as substrate, 81% inhibition
levodopa
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0.1 mM, inhibits activity with pyridoxal, but not with pyridoxamine as substrate, 16% inhibition
muzolimine
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0.1 mM, inhibits activity with pyridoxal, but not with pyridoxamine as substrate, 27% inhibition
NADH
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0.5 mM, 14% inhibition of activity with pyridoxine, 11% inhibition of activity with pyridoxal
picolinate
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0.5 mM, 95% inhibition of activity with pyridoxine, 97% inhibition of activity with pyridoxal
progabide
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0.1 mM, inhibits using either pyridoxamine or pyridoxal as substrate
quinolinate
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0.5 mM, 82% inhibition of activity with pyridoxine, 82% inhibition of activity with pyridoxal
rugulactone
selectively modifies the enzyme not at the active site cysteine, but on a remote cysteine residue
Thiamphenicol
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0.1 mM, inhibits activity with pyridoxal, but not with pyridoxamine as substrate, 31% inhibition
xanthurenate
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0.5 mM, 19% inhibition of activity with pyridoxine, 18% inhibition of activity with pyridoxal
dopamine
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0.1 mM, inhibits activity with pyridoxal, but not with pyridoxamine as substrate, 52% inhibition
pyridoxal
at high concentrations, substrate inhibition
pyridoxal 5'-phosphate
at high concentrations, product inhibition
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0.1 mM, inhibits using either pyridoxamine or pyridoxal as substrate, 86% inhibition of reaction with pyridoxal, 88% inhibition of reaction with pyridoxamine
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no inhibition of activity with pyridoxine, 72% inhibition of activity with pyridoxal
additional information
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ATP4- and HATP3- do not affect the enzyme activity. Free Mg2+ does not inhibit enzyme activity
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