Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.7.1.35: pyridoxal kinase

This is an abbreviated version!
For detailed information about pyridoxal kinase, go to the full flat file.

Word Map on EC 2.7.1.35

Reaction

ATP
+
pyridoxal
=
ADP
+
pyridoxal 5'-phosphate

Synonyms

ePL kinase, ePL kinase 1, hPL kinase, HPLK, kinase (phosphorylating), pyridoxal, kinase, pyridoxal (phosphorylating), LdPdxK, PdxK, pdxY, PKH, PL kinase, PLK, Plk1, PM kinase, PN kinase, PN/PL/PM kinase, pyridoxal 5-phosphate-kinase, pyridoxal kinase, pyridoxal kinase 1, pyridoxal kinase PKL, pyridoxal kinase-like protein SOS4, pyridoxal phosphokinase, pyridoxal/pyridoxine kinase, pyridoxamine kinase, pyridoxine kinase, pyridoxine/pyridoxal/pyridoxamine kinase, salt overly sensitive4, SAV0580, Sos4, StPLK, vitamin B6 kinase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.35 pyridoxal kinase

Inhibitors

Inhibitors on EC 2.7.1.35 - pyridoxal kinase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2-Diethylaminoethyl)hydrazine
-
0.005 mM, 20% inhibition
(R)-roscovitine
1,1-Bis(2-diethylaminoethyl)hydrazine
-
0.005 mM, 51% inhibition
1,4-diaminobutane
-
-
1,4-Diaminopiperazine
-
0.005 mM, 59% inhibition
1,6-diaminohexane
-
-
1,8-diaminooctane
-
-
1-(2-Hydrazinopropyl)piperidine
-
0.005 mM, 31% inhibition
1-(3-Dimethylamino-2-methylpropyl)hydrazine
-
0.005 mM, 39% inhibition
1-Aminopiperidine
-
0.005 mM, 58% inhibition
1-Cyclohexyl-1-methylhydrazine
-
0.005 mM, 29% inhibition
2,2'-hydrazinediethanol
-
0.005 mM, 47% inhibition
2,6-Dimethyl-3,4-bis(hydroxymethyl)pyridine
-
-
2-Methyl-3-amino-4,5,6-tris(hydroxymethyl)pyridine
-
-
2-Methyl-3-amino-4,5-bis(hydroxymethyl)pyridine
-
-
2-Methyl-3-hydroxy-5,6-bis(hydroxymethyl)pyridine
-
-
2-Methyl-4,5-bis(hydroxymethyl)pyridine
-
-
2-[1-(2-Diethylaminoethyl)hydrazine]ethanol
-
0.005 mM, 44% inhibition
3,4-dihydroxyphenylalanine
-
-
3-hydroxyanthranilic acid
-
IC50: 0.12 mM
3-hydroxykynurenine
-
IC50: 0.1 mM
4'-deoxypyridoxine
-
4'-O-methylpyridoxine
i.e. ginkgotoxin. Treatment leads to temporarily reduced pyridoxal phosphate formation in vitro and possibly in vivo
4-Aminomorpholine
-
0.005 mM, 52% inhibition
4-deoxypyridoxine
5-dimethylaminonaphthalene-1-sulfonyl-4-aminobutyrate
-
competitive with respect to pyridoxal
5-hydroxytryptamine
-
0.5 mM, 11% inhibition of activity with pyridoxine, 81% inhibition of activity with pyridoxal
ADP
at high concentrations, product inhibition
alpha-Methylphenethylhydrazine
alpha-Methylphenethylhydrazone
aminooxyacetic acid
-
0.002 mM, 50% inhibition
azine
Ca2+
-
low substrate inhibition
cadaverine
-
-
Caffeine
21% inhibition at 0.1 mM
Chloroquine
about 40% inhibition at 1 mM
Cr2+
-
-
cycloserine
-
0.1 mM, inhibits activity with pyridoxal, but not with pyridoxamine as substrate, 42% inhibition
D-penicillamine
-
0.1 mM, inhibits activity with pyridoxal, but not with pyridoxamine as substrate, 20% inhibition
dopamine
enprofylline
33% inhibition at 0.1 mM
gamma-aminobutyric acid
-
-
ginkgotoxin
histamine
-
-
hydrazine
hydroxylamine
isoniazid
-
0.1 mM, inhibits activity with pyridoxal, but not with pyridoxamine as substrate, 81% inhibition
K+
-
at high concentrations
L-canaline
-
0.01 mM, 50% inhibition
lamotrigine
45% inhibition at 0.1 mM
levodopa
-
0.1 mM, inhibits activity with pyridoxal, but not with pyridoxamine as substrate, 16% inhibition
Li+
-
at high concentrations
Mn2+
-
excess free divalent cations inhibit the enzyme
muzolimine
-
0.1 mM, inhibits activity with pyridoxal, but not with pyridoxamine as substrate, 27% inhibition
N,N'-Bis(pyridoxyl)hydrazine
-
0.0005 mM, 50% inhibition
N-Dansyl-1,8-diaminooctane
NADH
-
0.5 mM, 14% inhibition of activity with pyridoxine, 11% inhibition of activity with pyridoxal
norepinephrine
-
-
Octylhydrazine
-
0.005 mM, 53% inhibition
Oxime
picolinate
-
0.5 mM, 95% inhibition of activity with pyridoxine, 97% inhibition of activity with pyridoxal
primaquine
progabide
-
0.1 mM, inhibits using either pyridoxamine or pyridoxal as substrate
putrescine
-
-
pyridoxal
pyridoxal 5'-phosphate
pyridoxal semicarbazone
-
0.00005 mM, 50% inhibition
pyridoxal-gamma-aminobutyrate
-
-
pyridoxaloxime
pyridoxamine
pyridoxine
-
substrate inhibition above 0.2 mM
quinolinate
-
0.5 mM, 82% inhibition of activity with pyridoxine, 82% inhibition of activity with pyridoxal
quinolinic acid
-
IC50: 0.42 mM
roscovitine
-
-
rugulactone
selectively modifies the enzyme not at the active site cysteine, but on a remote cysteine residue
Semicarbazine
-
0.0005 mM, 50% inhibition
serotonin
spermidine
-
weak
spermine
-
weak
Theobromine
22% inhibition at 0.1 mM
theophylline
Thiamphenicol
-
0.1 mM, inhibits activity with pyridoxal, but not with pyridoxamine as substrate, 31% inhibition
tryptamine
tyramine
-
-
xanthurenate
-
0.5 mM, 19% inhibition of activity with pyridoxine, 18% inhibition of activity with pyridoxal
xanthurenic acid
-
IC50: 0.36 mM
ZnATP2-
-
weak substrate inhibition
additional information
-