2.7.1.35: pyridoxal kinase

This is an abbreviated version!
For detailed information about pyridoxal kinase, go to the full flat file.

Reaction

Synonyms

ePL kinase, ePL kinase 1, hPL kinase, HPLK, kinase (phosphorylating), pyridoxal, kinase, pyridoxal (phosphorylating), LdPdxK, PdxK, pdxY, PKH, PL kinase, PLK, Plk1, PM kinase, PN kinase, PN/PL/PM kinase, pyridoxal 5-phosphate-kinase, pyridoxal kinase, pyridoxal kinase 1, pyridoxal kinase PKL, pyridoxal kinase-like protein SOS4, pyridoxal phosphokinase, pyridoxal/pyridoxine kinase, pyridoxamine kinase, pyridoxine kinase, pyridoxine/pyridoxal/pyridoxamine kinase, salt overly sensitive4, SAV0580, Sos4, StPLK, vitamin B6 kinase

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.35 pyridoxal kinase

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Results	in table
4	Activating Compound
18327	AA Sequence
6	Application
1	CAS Registry Number
32	Cloned(Commentary)
10	Cofactor
18	Crystallization (Commentary)
88	Disease/ Diagnostics
1	Expression
25	General Information
5	General Stability
5	IC50 Value
129	Inhibitors
26	kcat/KM [mM/s]
16	Ki Value [mM]
122	KM Value [mM]
6	Localization
96	Metals/Ions
25	Molecular Weight [Da]
40	Natural Substrates/ Products (Substrates)
137	Organism
7	Pathway
98	PDB ID
22	pH Optimum
6	pH Range
1	pH Stability
6	pI Value
26	Protein Variants
45	Purification (Commentary)
2	Reaction
1	Reaction Type
94	Reference
1	Renatured (Commentary)
54	Source Tissue
29	Specific Activity [micromol/min/mg]
4	Storage Stability
191	Substrates and Products (Substrate)
32	Subunits
67	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
2	Temperature Range [°C]
3	Temperature Stability [°C]
69	Turnover Number [1/s]

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TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1.535 - 2.94

4'-deoxypyridoxine

2 entries

0.46

4'-O-methylpyridoxine

Homo sapiens

O00764

pH 6.2, 37°C

673580

0.044 - 0.36

4-Amino-5-hydroxymethyl-2-methylpyrimidine

3 entries

0.097 - 3.3

ATP

12 entries

0.46 - 106

ginkgotoxin

2 entries

0.015 - 131

pyridoxal

32 entries

0.03 - 127

pyridoxamine

8 entries

0.015 - 122

pyridoxine

9 entries

1.535

4'-deoxypyridoxine

Homo sapiens

O00764

pH 6.2, 37°C

673580

2.94

4'-deoxypyridoxine

Homo sapiens

O00764

in 70 mM potassium phosphate buffer, pH 6.2

673580

0.044

4-Amino-5-hydroxymethyl-2-methylpyrimidine

Staphylococcus aureus

A0A0H3JTP0

mutant C110A, pH not specified in the publication, temperature not specified in the publication

738451

0.045

4-Amino-5-hydroxymethyl-2-methylpyrimidine

Staphylococcus aureus

A0A0H3JTP0

wild-type, pH not specified in the publication, temperature not specified in the publication

738451

0.36

4-Amino-5-hydroxymethyl-2-methylpyrimidine

Bacillus subtilis

-

pH 8, 37°C

662007

0.097

ATP

Salmonella enterica subsp. enterica serovar Typhimurium

A0A0F7J8S0

with pyridoxamine, pH 8.5, 37°C

759183

0.107

ATP

Salmonella enterica subsp. enterica serovar Typhimurium

A0A0F7J8S0

with pyridoxal, pH 6.6, 37°C

759183

0.47

ATP

Homo sapiens

O00764

pH 7.3, 37°C recombinant mutant A243G

760178

0.58

ATP

Homo sapiens

O00764

pH 7.3, 37°C recombinant mutant H246Q

760178

0.67

ATP

Homo sapiens

O00764

pH 7.3, 37°C recombinant mutant D87H

760178

0.97

ATP

Homo sapiens

O00764

pH 7.3, 37°C recombinant wild-type enzyme

760178

1.02

ATP

Leishmania donovani

A0A0G2YFI9

recombinant wild-type enzyme, pH 7.2, 37°C

759342

1.12

ATP

Homo sapiens

O00764

pH 7.3, 37°C recombinant mutant V128I

760178

1.23

ATP

Bombyx mori

Q1PCB1

in 70 mM potassium phosphate (pH 5.5), 0.5 mM ZnCl2, at 37°C

722183

1.8

ATP

Pseudomonas aeruginosa

-

mutant enzyme C124A, at pH 7.4 and 37°C

737622

1.9

ATP

Homo sapiens

-

in the presence of Zn2+, at pH 6.5 and 37°C

737809

3.3

ATP

Pseudomonas aeruginosa

-

wild type enzyme, at pH 7.4 and 37°C

737622

0.46

ginkgotoxin

Homo sapiens

O00764

in 70 mM potassium phosphate buffer, pH 6.2

673580

106

ginkgotoxin

Trypanosoma brucei

-

recombinant enzyme, in HEPES/MgCl2 pH 7.4, 0.15 mM ZnCl2, at 37°C

723219

0.015

pyridoxal

Trypanosoma cruzi

Q4D946

in the presence of K+, at pH 7.0 and 30°C

738236

0.03

pyridoxal

Homo sapiens

O00764

D235A mutant protein

702038

0.032

pyridoxal

Bacillus subtilis

-

pH 8, 37°C

662007

0.05

pyridoxal

Plasmodium falciparum

-

pH 6.5, 30°C

662440

0.073

pyridoxal

Plasmodium vivax

A5K1Z8

in the presence of K+, at pH 7.0 and 30°C

738236

0.107

pyridoxal

Salmonella enterica subsp. enterica serovar Typhimurium

A0A0F7J8S0

pH 6.6, 37°C

759183

0.12

pyridoxal

Homo sapiens

-

in the presence of K+, at pH 7.0 and 30°C

738236

0.165

pyridoxal

Staphylococcus aureus

A0A0H3JTP0

wild-type, pH not specified in the publication, temperature not specified in the publication

738451

0.23

pyridoxal

Homo sapiens

O00764

D235N mutant protein

702038

0.23

pyridoxal

Homo sapiens

-

in the presence of Na+, at pH 7.0 and 30°C

738236

0.328

pyridoxal

Staphylococcus aureus

A0A0H3JTP0

mutant C214D, pH not specified in the publication, temperature not specified in the publication

738451

0.4

pyridoxal

Trypanosoma brucei

-

pH 7, 37°C, recombinant enzyme

641426

0.47

pyridoxal

Homo sapiens

O00764

pH 7.3, 37°C recombinant mutant A243G

760178

0.48

pyridoxal

Homo sapiens

O00764

wild-type protein

702038

0.5

pyridoxal

Homo sapiens

O00764

with ZnATP2- as substrate, pH 7.3, 37°C

663303

0.58

pyridoxal

Homo sapiens

O00764

pH 7.3, 37°C recombinant mutant H246Q

760178

0.67

pyridoxal

Homo sapiens

O00764

pH 7.3, 37°C recombinant mutant D87H

760178

0.8

pyridoxal

Homo sapiens

O00764

with MgATP2- as substrate, pH 7.3, 37°C

663303

0.97

pyridoxal

Homo sapiens

O00764

pH 7.3, 37°C recombinant wild-type enzyme

760178

0.995

pyridoxal

Homo sapiens

O00764

pH 6.2, 37°C

673580

1.12

pyridoxal

Homo sapiens

O00764

pH 7.3, 37°C recombinant mutant V128I

760178

1.3

pyridoxal

Pseudomonas aeruginosa

-

wild type enzyme, at pH 7.4 and 37°C

737622

1.35

pyridoxal

Bombyx mori

Q1PCB1

in 70 mM potassium phosphate (pH 5.5), 0.5 mM ZnCl2, at 37°C

722183

1.42

pyridoxal

Homo sapiens

O00764

presence of 40 mM K+, pH 7.3, 37°C

677029

1.5

pyridoxal

Leishmania donovani

A0A0G2YFI9

recombinant wild-type enzyme, pH 7.2, 37°C

759342

2

pyridoxal

Escherichia coli

-

kinase 1 with ZnATP2- as substrate, pH 7.3, 37°C

663303

2.3

pyridoxal

Escherichia coli

-

kinase 1 with MgATP2- as substrate, pH 7.3, 37°C

663303

3.2

pyridoxal

Homo sapiens

-

at pH 6.5 and 37°C

737809

3.3

pyridoxal

Homo sapiens

O00764

presence of 40 mM Na+, pH 7.3, 37°C

677029

4.7

pyridoxal

Pseudomonas aeruginosa

-

mutant enzyme C124A, at pH 7.4 and 37°C

737622

6.08

pyridoxal

Homo sapiens

O00764

in 70 mM potassium phosphate buffer, pH 6.2

673580

131

pyridoxal

Trypanosoma brucei

-

recombinant enzyme, in HEPES/MgCl2 pH 7.4, 0.15 mM ZnCl2, at 37°C

723219

0.03

pyridoxamine

Plasmodium falciparum

-

pH 6.5, 30°C

662440

0.097

pyridoxamine

Salmonella enterica subsp. enterica serovar Typhimurium

A0A0F7J8S0

pH 8.5, 37°C

759183

0.3

pyridoxamine

Homo sapiens

O00764

with MgATP2- as substrate, pH 7.3, 37°C

663303

0.4

pyridoxamine

Escherichia coli

-

kinase 1 with ZnATP2- as substrate, pH 7.3, 37°C

663303

0.7

pyridoxamine

Escherichia coli

-

kinase 1 with MgATP2- as substrate, pH 7.3, 37°C

663303

0.79

pyridoxamine

Homo sapiens

O00764

in 70 mM potassium phosphate buffer, pH 6.2

673580

0.79

pyridoxamine

Homo sapiens

O00764

pH 6.2, 37°C

673580

127

pyridoxamine

Trypanosoma brucei

-

recombinant enzyme, in HEPES/MgCl2 pH 7.4, 0.15 mM ZnCl2, at 37°C

723219

0.015

pyridoxine

Staphylococcus aureus

A0A0H3JTP0

mutant C110A, pH not specified in the publication, temperature not specified in the publication

738451

0.016

pyridoxine

Staphylococcus aureus

A0A0H3JTP0

wild-type, pH not specified in the publication, temperature not specified in the publication

738451

0.1

pyridoxine

Homo sapiens

O00764

with ZnATP2- as substrate, pH 7.3, 37°C

663303

0.11

pyridoxine

Plasmodium falciparum

-

pH 6.5, 30°C

662440

0.3

pyridoxine

Escherichia coli

-

kinase 1 with MgATP2- as substrate, pH 7.3, 37°C

663303

0.3

pyridoxine

Homo sapiens

O00764

with MgATP2- as substrate, pH 7.3, 37°C

663303

1.233

pyridoxine

Homo sapiens

O00764

pH 6.2, 37°C

673580

6.08

pyridoxine

Homo sapiens

O00764

in 70 mM potassium phosphate buffer, pH 6.2

673580

122

pyridoxine

Trypanosoma brucei

-

recombinant enzyme, in HEPES/MgCl2 pH 7.4, 0.15 mM ZnCl2, at 37°C

723219