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2.7.1.36: mevalonate kinase

This is an abbreviated version!
For detailed information about mevalonate kinase, go to the full flat file.

Word Map on EC 2.7.1.36

Reaction

ATP
+
(R)-mevalonate
=
ADP
+
(R)-5-phosphomevalonate

Synonyms

ATP: mevalonate 5-phosphotransferase, ATP:mevalonate 5-phosphotransferase, GbMVK, kinase, mevalonate (phosphorylating), mevalonate 5-phosphotransferase, mevalonate phosphokinase, mevalonic acid kinase, mevalonic kinase, MmMK, MVA kinase, MVK, SSO0383, TcMVK, TeMVK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.36 mevalonate kinase

Activating Compound

Activating Compound on EC 2.7.1.36 - mevalonate kinase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
arsenate
-
hyperbolic activation curve, 13% activation at 25 mM, 87% activation at 500 mM
atorvastatin
-
besides increases in mRNA level of HMG CoA reductase, treatment increases hepatic mRNA levels of both mevalonate kinase and cob(I)alamin adenosyltransferase
ATP4-
-
most effective activator, maximal activation at 8 mM
cysteine
iodoacetamide
-
10 mM, 20% activation
phosphate
testosterone
treatment of meibomian gland stimulates a significant increase in the mRNA levels of mevalonate kinase, phosphomevalonate kinase, mevalonate diphosphate decarboxylase, isopentenyl diphosphate isomerase, geranylgeranyl diphosphate synthase, squalene epoxidase, lanosterol synthase, lanosterol demethylase, and DELTA7-sterol reductase
UTP
-
stimulation of ATP utilization