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2.7.1.36: mevalonate kinase

This is an abbreviated version!
For detailed information about mevalonate kinase, go to the full flat file.

Word Map on EC 2.7.1.36

Reaction

ATP
+
(R)-mevalonate
=
ADP
 +
(R)-5-phosphomevalonate

Synonyms

ATP: mevalonate 5-phosphotransferase, ATP:mevalonate 5-phosphotransferase, GbMVK, kinase, mevalonate (phosphorylating), mevalonate 5-phosphotransferase, mevalonate phosphokinase, mevalonic acid kinase, mevalonic kinase, MmMK, MVA kinase, MVK, SSO0383, TcMVK, TeMVK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.36 mevalonate kinase

Cloned

Cloned on EC 2.7.1.36 - mevalonate kinase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloning of ERG12 gene
-
DNA and amino acid sequence determination and analysis, sequence comparisons, recombinant expression of N-terminally His6-tagged enzyme in Escherichia coli strain BL21(DE3)
-
DNA and amino acid sequence determination and anaylsis, overexpression in a procyclic form of Trypanosoma brucei, and expression of His-tagged wild-type enzyme in Escherichia coli strain BL21(DE3), and of His-tagged selenomethionine-labeled enzyme in Escherichia coli strain B834
DNA and amino acid sequence determination and anaylsis, overexprssion in a procyclic form of Trypanosoma brucei
-
expressed as His-tag fusion protein in Escherichia coli BL21(DE3)
-
expressed in Escherichia coli
-
expressed in Escherichia coli BL21 cells
expressed in Escherichia coli BL21 Star (lambdaDE3) cells
-
expressed in Escherichia coli BL21(DE3)
-
expressed in Escherichia coli BL21(DE3) cells
expressed in HEK293 Flp-In and CV1 Flp-In cells
-
expression in 293T cell
-
expression in Escherichia coli
expression in Trypanosoma brucei
expression of His-tagged mevalonate kinase in Escherichia coli
-
expression of wild-type and N301T mutant mevalonate kinase in COS-7 cells
gene MVK, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, expression and functional complementation of GbMVK in haploid disrupted MVK-deficient Saccharomyces cerevisiae strain DELTAerg12. Quantitative RT-PCR enzyme expression analysis
gene MVK, genotyping
gene MVK, location on chromosome 12q24
-
native and mutant enzymes expressed as His-tag fusion proteins in Escherichia coli BL21(DE3)
-
overexpression in Escherichia coli
-
overexpression in Escherichia coli as dual-tagged His6-GST fusion protein
recombinant expression of His-tagged enzyme in Escherichia coli strain BL21(DE3), subcloning in Escherichia coli strain DH10B
-
the mevalonate kinase (MVK) gene has 10 coding exons and one non-coding exon at chromosome 12q24, the MVK protein is encoded by two transcripts of MVK. Recombinant expression of the enzyme in HaCat human keratinocytes using viral vectors, quantitative reverse transcription-PCR enzyme expression analysis