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2.7.1.36: mevalonate kinase

This is an abbreviated version!
For detailed information about mevalonate kinase, go to the full flat file.

Word Map on EC 2.7.1.36

Reaction

ATP
+
(R)-mevalonate
=
ADP
 +
(R)-5-phosphomevalonate

Synonyms

ATP: mevalonate 5-phosphotransferase, ATP:mevalonate 5-phosphotransferase, GbMVK, kinase, mevalonate (phosphorylating), mevalonate 5-phosphotransferase, mevalonate phosphokinase, mevalonic acid kinase, mevalonic kinase, MmMK, MVA kinase, MVK, SSO0383, TcMVK, TeMVK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.36 mevalonate kinase

Temperature Stability

Temperature Stability on EC 2.7.1.36 - mevalonate kinase

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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
100
-
50% loss of activity after 5 min
20 - 30
the enzyme is stable at 20-25°C for 80 min and at optimum temperature 30°C for 40 min
37
-
approx. 50% and 70% loss of activity after 40 min and 90 min, respectively, H20P/V377I double mutant is only slightly more temperature sensitive
44
-
10 min, residual activity of wild-type 50%, of mutant A141C 85%
47
-
10 min, residual activity of wild-type 15%, of mutant A141C 55%
70
-
no loss of activity after 24 h
80
-
1 h, 60% loss of activity
83
-
10 min, residual activity of wild-type 50%, mutants C107S and C281S 20%, mutant C107S/C281S 15%, mutants C107A and C281A 20%, mutant C107A/C281A 18%
90
-
50% loss of activity after 15 min