2.7.1.39: homoserine kinase
This is an abbreviated version!
For detailed information about homoserine kinase, go to the full flat file.
Word Map on EC 2.7.1.39
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2.7.1.39
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keratitis
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herpes
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simplex
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corneal
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herpetic
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horseshoe
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immunopathological
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keratoplasty
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opacity
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virus-1
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immunoinflammatory
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isthmus
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trigeminal
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hsv-specific
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acyclovir
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anti-hsv
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phosphomevalonate
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agriculture
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slit-lamp
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aspartokinase
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drug development
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nephrolithotomy
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transperitoneal
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stone-free
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mckrae
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medicine
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lithotripsy
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hsv-infected
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hsv-1-induced
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lactofermentum
- 2.7.1.39
- keratitis
-
herpes
- simplex
- corneal
-
herpetic
-
horseshoe
-
immunopathological
-
keratoplasty
- opacity
-
virus-1
-
immunoinflammatory
-
isthmus
-
trigeminal
-
hsv-specific
- acyclovir
-
anti-hsv
- phosphomevalonate
- agriculture
-
slit-lamp
- aspartokinase
- drug development
-
nephrolithotomy
-
transperitoneal
-
stone-free
-
mckrae
- medicine
-
lithotripsy
-
hsv-infected
-
hsv-1-induced
- lactofermentum
Reaction
Synonyms
CglThrB, CThrB, DMR1, homoserine kinase, homoserine kinase (phosphorylating), HSK, kinase (phosphorylating), homoserine, kinase, homoserine (phosphorylating), Thr1, Thr1p, ThrB
ECTree
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General Information
General Information on EC 2.7.1.39 - homoserine kinase
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malfunction
metabolism
downy mildew resistance is mediated by mutation of homoserine kinase: homoserine accumulation in the chloroplast triggers a novel form of downy mildew resistance
additional information
malfunction
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homoserine kinase deletion mutants are attenuated in virulence and die rapidly upon threonine starvation and serum incubation
malfunction
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homoserine kinase deletion mutants are extremely serum sensitive and hypersensitive to DNA-damaging agents
malfunction
mutations in the Arabidopsis homoserine kinase gene DMR1 confer enhanced resistance to Fusarium culmorum and Fusarium graminearum which cause Fusarium Ear Blight disease on small grain cereals
a conserved active-site alanine residue, A20, in CThrB (CglThrB) is important for differential interactions with L-threonine and L-homoserine
additional information
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a conserved active-site alanine residue, A20, in CThrB (CglThrB) is important for differential interactions with L-threonine and L-homoserine
additional information
molecular modeling and simulation study of homoserine kinase (HSK) as an effective leishmanial drug target. Two MD simulations are performed on HSK enzyme without substrate (for reference), and on the enzyme in complex with the substrate, prosthetic group, and the magnesium ion using the NAMD program with CHARMM all-atom force field. The topology and parameters for the ligands used in this study are obtained from the MATCH web server. Virtual screening of a compound library and docking study. Homology modeling using several templates, overview. The active site of HSK mainly constitutes of two aspartates, two asparagine residues, and an arginine. All these residues are found to be optimally placed in the predicted model (Asn23, Asp29, Asp144, Asn145, and Arg241). Substrate recognition and structure-function analysis
additional information
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a conserved active-site alanine residue, A20, in CThrB (CglThrB) is important for differential interactions with L-threonine and L-homoserine
-
additional information
-
a conserved active-site alanine residue, A20, in CThrB (CglThrB) is important for differential interactions with L-threonine and L-homoserine
-
additional information
-
a conserved active-site alanine residue, A20, in CThrB (CglThrB) is important for differential interactions with L-threonine and L-homoserine
-
additional information
-
a conserved active-site alanine residue, A20, in CThrB (CglThrB) is important for differential interactions with L-threonine and L-homoserine
-
additional information
-
a conserved active-site alanine residue, A20, in CThrB (CglThrB) is important for differential interactions with L-threonine and L-homoserine
-
additional information
-
a conserved active-site alanine residue, A20, in CThrB (CglThrB) is important for differential interactions with L-threonine and L-homoserine
-