2.7.1.39: homoserine kinase
This is an abbreviated version!
For detailed information about homoserine kinase, go to the full flat file.
Word Map on EC 2.7.1.39
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2.7.1.39
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keratitis
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herpes
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simplex
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corneal
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herpetic
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horseshoe
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immunopathological
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keratoplasty
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opacity
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virus-1
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immunoinflammatory
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isthmus
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trigeminal
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hsv-specific
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acyclovir
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anti-hsv
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phosphomevalonate
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agriculture
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slit-lamp
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aspartokinase
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drug development
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nephrolithotomy
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transperitoneal
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stone-free
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mckrae
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medicine
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lithotripsy
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hsv-infected
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hsv-1-induced
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lactofermentum
- 2.7.1.39
- keratitis
-
herpes
- simplex
- corneal
-
herpetic
-
horseshoe
-
immunopathological
-
keratoplasty
- opacity
-
virus-1
-
immunoinflammatory
-
isthmus
-
trigeminal
-
hsv-specific
- acyclovir
-
anti-hsv
- phosphomevalonate
- agriculture
-
slit-lamp
- aspartokinase
- drug development
-
nephrolithotomy
-
transperitoneal
-
stone-free
-
mckrae
- medicine
-
lithotripsy
-
hsv-infected
-
hsv-1-induced
- lactofermentum
Reaction
Synonyms
CglThrB, CThrB, DMR1, homoserine kinase, homoserine kinase (phosphorylating), HSK, kinase (phosphorylating), homoserine, kinase, homoserine (phosphorylating), Thr1, Thr1p, ThrB
ECTree
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Inhibitors
Inhibitors on EC 2.7.1.39 - homoserine kinase
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(1R,3r,5S)-8-[(1-cyclohexyl-1H-tetrazol-5-yl)methyl]-3-(pyridin-3-yl)-8-azabicyclo[3.2.1]octan-3-ol
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(naphthalen-1-yl)(1,3,5-triazatricyclo[3.3.1.13,7]decan-7-yl)methanone
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1-(3,4-dihydroquinolin-1(2H)-yl)-2-[[1-(4-methylphenyl)-1H-tetrazol-5-yl]sulfanyl]ethan-1-one
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1-[(2R,6S)-2,6-dimethylpiperidin-1-yl]-2-[([1,2,4]triazolo[4,3-a]pyrimidin-3-yl)sulfanyl]ethan-1-one
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1-[(2R,6S)-2,6-dimethylpiperidin-1-yl]-2-[4-(4-methylbenzoyl)piperidin-1-yl]ethan-1-one
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2-(2-methylpropyl)-6,7,8,9-tetrahydro-4H,5H-cyclohepta[4,5]thieno[2,3-d][1,3]oxazin-4-one
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2-(3,4-dihydroxyphenyl)-3,6,7-trihydroxy-2,3-dihydro-4H-chromen-4-one
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2-[(5-amino-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(naphthalen-1-yl)acetamide
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3-methyl-1-phenyl-6-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-4-ol
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4-hydroxy-3-[(4-hydroxy-2-oxo-3,8a-dihydro-2H-chromen-3-yl)methyl]-2H-chromen-2-one
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L-homoserine ethyl ester
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unlike the wild-type enzyme the mutant enzyme H202L is inhibited
L-homoserine isopropyl ester
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unlike the wild-type enzyme the mutant enzyme H202L is inhibited
L-homoserine n-propyl ester
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unlike the wild-type enzyme the mutant enzyme H202L is inhibited
N-[(3r)-adamantan-1-yl]-2-[3-(2-methylphenyl)-6-oxopyridazin-1(6H)-yl]acetamide
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competitive inhibition, interaction with ThrB residue A20 is important. Highly reduced inhibition of enzyme mutant A20G. The changes in L-threonine affinity to the CglThrB-A20G active site derive from loss of van der Waals interactions
additional information
virtual screening of a compound library and docking study, binding free energies, overview
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