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2.7.1.39: homoserine kinase

This is an abbreviated version!
For detailed information about homoserine kinase, go to the full flat file.

Word Map on EC 2.7.1.39

Reaction

ATP
+
L-homoserine
=
ADP
+
O-phospho-L-homoserine

Synonyms

CglThrB, CThrB, DMR1, homoserine kinase, homoserine kinase (phosphorylating), HSK, kinase (phosphorylating), homoserine, kinase, homoserine (phosphorylating), Thr1, Thr1p, ThrB

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.39 homoserine kinase

Inhibitors

Inhibitors on EC 2.7.1.39 - homoserine kinase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1R,3r,5S)-8-[(1-cyclohexyl-1H-tetrazol-5-yl)methyl]-3-(pyridin-3-yl)-8-azabicyclo[3.2.1]octan-3-ol
-
(2S)-1-(9H-carbazol-9-yl)-3-(piperazin-1-yl)propan-2-ol
-
(2Z)-2-cyano-N-(2,5-dibromophenyl)-3-hydroxybut-2-enamide
-
-
(4R)-4-hydroxypentan-2-one
-
-
(naphthalen-1-yl)(1,3,5-triazatricyclo[3.3.1.13,7]decan-7-yl)methanone
-
(p-hydroxyphenyl)-glyoxal
-
-
1-(3,4-dihydroquinolin-1(2H)-yl)-2-[[1-(4-methylphenyl)-1H-tetrazol-5-yl]sulfanyl]ethan-1-one
-
1-(naphthalen-2-yl)prop-2-en-1-one
-
-
1-[(2R,6S)-2,6-dimethylpiperidin-1-yl]-2-[([1,2,4]triazolo[4,3-a]pyrimidin-3-yl)sulfanyl]ethan-1-one
-
1-[(2R,6S)-2,6-dimethylpiperidin-1-yl]-2-[4-(4-methylbenzoyl)piperidin-1-yl]ethan-1-one
-
2-(2-methylpropyl)-6,7,8,9-tetrahydro-4H,5H-cyclohepta[4,5]thieno[2,3-d][1,3]oxazin-4-one
-
-
2-(3,4-dihydroxyphenyl)-3,6,7-trihydroxy-2,3-dihydro-4H-chromen-4-one
-
-
2-amino-3-(phosphonoethyl)thiopropionate
-
-
2-Amino-5-phosphonovalerate
-
-
2-amino-5-phosphovalerate
-
-
2-chloro-L-alanine
-
-
2-[(5-amino-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(naphthalen-1-yl)acetamide
-
3-methyl-1-phenyl-6-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-4-ol
-
-
4-hydroxy-3-[(4-hydroxy-2-oxo-3,8a-dihydro-2H-chromen-3-yl)methyl]-2H-chromen-2-one
-
-
5'-adenylylimidodiphosphate
-
-
6-hydroxy-DL-Lys
-
5 mM, 92% inhibition
alpha-amino-beta-hydroxy valeric acid
-
-
diethyl dicarbonate
-
-
L-2-amino-5-hydroxyvalerate
-
substrate inhibition
L-2-aminobutyrate
-
-
L-2-aminobutyric acid
-
40 mM, 50% inhibition
L-alpha-aminobutyric acid
-
-
L-Arg
-
10 mM, 13% inhibition
L-aspartate
-
slight
L-aspartate semialdehyde
-
mixed inhibition versus L-homoserine and ATP
L-Cys
L-Glutamic acid
-
-
L-homocysteine
-
-
L-homoserine
L-homoserine alpha-methyl ester
-
substrate inhibition
L-homoserine ethyl ester
-
unlike the wild-type enzyme the mutant enzyme H202L is inhibited
L-homoserine isopropyl ester
-
unlike the wild-type enzyme the mutant enzyme H202L is inhibited
L-homoserine n-propyl ester
-
unlike the wild-type enzyme the mutant enzyme H202L is inhibited
L-Ile
L-Leu
-
10 mM, 20% inhibition
L-Lys
-
10 mM, 35% inhibition
L-Met
L-norvaline
-
-
L-Orn
-
10 mM, 64% inhibition
L-Ser
L-Thr
L-threonine
L-Val
N,N'-(pyridine-2,5-diyl)dicyclohexanecarboxamide
-
N-[(3r)-adamantan-1-yl]-2-[3-(2-methylphenyl)-6-oxopyridazin-1(6H)-yl]acetamide
-
O-Phospho-DL-homoserine
-
10 mM, 91% inhibition
O-phospho-L-serine
-
-
phosphohomoserine
-
inhibits phosphorylation of L-homoserine
pyridoxal 5'-phosphate
-
-
S-adenosyl-L-methionine
additional information
-