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2.7.1.40: pyruvate kinase

This is an abbreviated version!
For detailed information about pyruvate kinase, go to the full flat file.

Word Map on EC 2.7.1.40

Reaction

ATP
+
pyruvate
=
ADP
 +
phosphoenolpyruvate

Synonyms

ATP/pyruvate O'-phosphotransferase, ATP:pyruvate 2-O-phosphotransferase, CPK, CPK1, cPK2, cPK3, cPK4, cPK5, CTHBP, cytosolic pyruvate kinase, cytosolic thyroid hormone binding protein, EHI_098420, EhPK, EhPyk, erythroid (R-type) pyruvate kinase, fluorokinase, hL-PYK, hLPYK, hPKM2, K+-dependent PK, K+-independent PK, kinase, fluoro- (phosphorylating), kinase, pyruvate (phosphorylating), L-PK , L-PYK, liver PK, liver pyruvate kinase, M1-PK, M1-PYK, M2 pyruvate kinase, M2 type phosphoenolpyruvate kinase, M2-PK, M2-pyruvate kinase, M2-type pyruvate kinase, M2PK, mPKM2, MRSA PK, muscle PK, NCgl2008, NCgl2809, PAE0819, PfPYK, pfPyrK, phosphoenol transphosphorylase, phosphoenolpyruvate kinase, phosphoenolpyruvate: ADP phosphotransferase, PK-alphabeta1, PK-alphabeta2, PK-M1, PK-M2, PK-R, PK-S, PK1, PK3, PKC, PKC1, PKL, Pklr, PKM1, PKM2, PKp, ProTalphaK, PYK, PYK-I, Pyk1, Pyk2, PykA, PykF, PyKII, pyruvate kinase, pyruvate kinase 1, pyruvate kinase isoenzyme M2, pyruvate kinase isoform M2, pyruvate kinase isoforms 2, pyruvate kinase isozyme M1, pyruvate kinase isozyme type M2, pyruvate kinase M1, pyruvate kinase M2, pyruvate kinase M2 isoform, pyruvate kinase muscle isoform 2, pyruvate kinase muscle isozyme, pyruvate kinase type M2, pyruvate kinase type-II, pyruvate phosphotransferase, pyruvic kinase, R-type pyruvate kinase, R-type/L-type pyruvate kinase, red cell/liver pyruvate kinase, rM1-PYK, RMPK, RPK, Rv1617, SSO0981, TbrPYK, TCIL3000_10_12020, TcoPYK, THBP1, TuM2-PK, tumor cell specific pyruvate kinase isozyme M2, tumour M2-PK, tumour M2-pyruvate kinase, VcIIPK, VcIPK, VC_0485, VC_2008, VEG17, vegetative protein 17, vesicle-associated pyruvate kinase, YPK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.40 pyruvate kinase

Expression

Expression on EC 2.7.1.40 - pyruvate kinase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
complete absence of M2-pyruvate kinase expression in benign pancreatic ductal epithelium and pancreaticobiliary and duodenal neoplasia
-
HIF-1alpha induces an increased transcription of the pyruvate kinase M gene.. Induction of M2-PK expression by hypermethylated secreted frizzled related protein and mutated adenomatous polyposis coli protein, APC, overview
-
in children, pyruvate kinase (PK) activity increases significantly in dental plaque corresponding with the caries progression. Streptococcus mutans (MS) and its biotype I are the strains most frequently found in dental plaque of young children. The correlation between the level of Streptococcus mutans in dental plaque and PK activity is both statistically significant and positive
in tongue squamous cell carcinoma cell lines, PKM2 expression is reduced in response to miR-133a and miR-133b precursors transfection
-
oxaliplatin exposure in both HT-29 and HTOXAR-3 cells leads to PK-M2 mRNA up-regulation
-
patients with colorectal adenocarcinoma have the highest median faecal tumour M2-PK level
-
PK-M2 is down-regulates in HTOXAR-3 cells, there is a negative correlation between oxaliplatin resistance and PK-M2 mRNA levels
-
PKM2 is overexpressed in tongue squamous cell carcinoma cells and is associated with the downregulation of miR-133a and miR-133b
-
pyruvate kinase activities are increased by 52.4% in nerve growth factor treatment compared to the cells cultured by horse serum media
-
the cytosolic PKs are induced in response to cold treatment. cPK1 and cPK2 expression is induced, whereas cPK3 transcript levels are not altered. The strongest induction upon cold treatment is found for the isogenes cPK4 and cPK5
the mRNA level of pyk2 in the wild-type strain under oxygen deprivation is 14.24fold higher than that under aerobic conditions. Expression of pyk2 is induced under oxygen deprivation
tumor-associated dendritic cells with higher levels of SOCS3 have reduced M2-PK activity
-
two patients with transfusion-dependent anemia reveal red blood cell pyruvate kinase to be 33% and 41% of the mean normal value
-