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2.7.1.40: pyruvate kinase

This is an abbreviated version!
For detailed information about pyruvate kinase, go to the full flat file.

Word Map on EC 2.7.1.40

Reaction

ATP
+
pyruvate
=
ADP
 +
phosphoenolpyruvate

Synonyms

ATP/pyruvate O'-phosphotransferase, ATP:pyruvate 2-O-phosphotransferase, CPK, CPK1, cPK2, cPK3, cPK4, cPK5, CTHBP, cytosolic pyruvate kinase, cytosolic thyroid hormone binding protein, EHI_098420, EhPK, EhPyk, erythroid (R-type) pyruvate kinase, fluorokinase, hL-PYK, hLPYK, hPKM2, K+-dependent PK, K+-independent PK, kinase, fluoro- (phosphorylating), kinase, pyruvate (phosphorylating), L-PK , L-PYK, liver PK, liver pyruvate kinase, M1-PK, M1-PYK, M2 pyruvate kinase, M2 type phosphoenolpyruvate kinase, M2-PK, M2-pyruvate kinase, M2-type pyruvate kinase, M2PK, mPKM2, MRSA PK, muscle PK, NCgl2008, NCgl2809, PAE0819, PfPYK, pfPyrK, phosphoenol transphosphorylase, phosphoenolpyruvate kinase, phosphoenolpyruvate: ADP phosphotransferase, PK-alphabeta1, PK-alphabeta2, PK-M1, PK-M2, PK-R, PK-S, PK1, PK3, PKC, PKC1, PKL, Pklr, PKM1, PKM2, PKp, ProTalphaK, PYK, PYK-I, Pyk1, Pyk2, PykA, PykF, PyKII, pyruvate kinase, pyruvate kinase 1, pyruvate kinase isoenzyme M2, pyruvate kinase isoform M2, pyruvate kinase isoforms 2, pyruvate kinase isozyme M1, pyruvate kinase isozyme type M2, pyruvate kinase M1, pyruvate kinase M2, pyruvate kinase M2 isoform, pyruvate kinase muscle isoform 2, pyruvate kinase muscle isozyme, pyruvate kinase type M2, pyruvate kinase type-II, pyruvate phosphotransferase, pyruvic kinase, R-type pyruvate kinase, R-type/L-type pyruvate kinase, red cell/liver pyruvate kinase, rM1-PYK, RMPK, RPK, Rv1617, SSO0981, TbrPYK, TCIL3000_10_12020, TcoPYK, THBP1, TuM2-PK, tumor cell specific pyruvate kinase isozyme M2, tumour M2-PK, tumour M2-pyruvate kinase, VcIIPK, VcIPK, VC_0485, VC_2008, VEG17, vegetative protein 17, vesicle-associated pyruvate kinase, YPK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.40 pyruvate kinase

IC50 Value

IC50 Value on EC 2.7.1.40 - pyruvate kinase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.01566
(1,4-dimethoxynaphthalen-2-yl)methyl dipropylcarbamodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.00258
(1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl diethylcarbamodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.00423
(1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl morpholine-4-carbodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.00174
(1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl piperidine-1-carbodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.0014
(1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl [4-(piperazin-1-yl)phenyl]carbamodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.00278
(1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)bis(methylene) bis(diethylcarbamodithioate)
Homo sapiens
pH 7.5, 37°C, recombinant enzyme
0.01
(1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)bis(methylene) bis(dimethylcarbamodithioate)
Homo sapiens
pH 7.5, 37°C, recombinant enzyme
0.01
(1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)bis(methylene) bis(diprop-2-en-1-ylcarbamodithioate)
Homo sapiens
pH 7.5, 37°C, recombinant enzyme
0.00308
(1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)bis(methylene) bis(dipropylcarbamodithioate)
Homo sapiens
pH 7.5, 37°C, recombinant enzyme
0.00096
(1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)bis(methylene) di(1,3-thiazolidine-3-carbodithioate)
Homo sapiens
pH 7.5, 37°C, recombinant enzyme
0.00264
(1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)bis(methylene) dimorpholine-4-carbodithioate
Homo sapiens
pH 7.5, 37°C, recombinant enzyme
0.00233
(1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)bis(methylene) dipyrrolidine-1-carbodithioate
Homo sapiens
pH 7.5, 37°C, recombinant enzyme
0.00105
(1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)bis(methylene) dithiomorpholine-4-carbodithioate
Homo sapiens
pH 7.5, 37°C, recombinant enzyme
0.0168
(1S,3S)-1,3-di(1H-indol-3-yl)-1,2,3,4-tetrahydrocyclopenta[b]indole
Staphylococcus aureus
-
precombinant enzyme, pH 7.5, 30°C
0.0061
(1S,3S)-2-bromo-1,3-di(1H-indol-3-yl)-1,2,3,4-tetrahydrocyclopenta[b]indole
Staphylococcus aureus
-
precombinant enzyme, pH 7.5, 30°C
0.0068
(1S,3S)-2-chloro-1,3-di(1H-indol-3-yl)-1,2,3,4-tetrahydrocyclopenta[b]indole
Staphylococcus aureus
-
precombinant enzyme, pH 7.5, 30°C
0.0085
(1S,4S)-1,4-di(1H-indol-3-yl)-2,3,4,9-tetrahydro-1H-carbazole
Staphylococcus aureus
-
precombinant enzyme, pH 7.5, 30°C
0.05
(1S,4S)-6-chloro-1,4-bis(5-chloro-1H-indol-3-yl)-2,3,4,9-tetrahydro-1H-carbazole
Staphylococcus aureus
-
precombinant enzyme, pH 7.5, 30°C
0.000185
(2-[(1E)-1-[2-(5-bromo-2-hydroxybenzoyl)hydrazinylidene]ethyl]-1-methyl-1H-indol-6-yl)dibromanium
Staphylococcus aureus
-
pH not specified in the publication, 30°C
0.000553
(2E)-1-(4-bromo-2-hydroxyphenyl)-3-(1H-indol-2-yl)prop-2-en-1-one
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000132
(2E)-1-(4-bromo-2-hydroxyphenyl)-3-(6-bromo-1H-indol-2-yl)prop-2-en-1-one
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.163
(2E)-1-(4-methoxyphenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one
Homo sapiens
-
at pH 8.0 and 22°C
0.000005
(2E)-1-(6-bromo-1H-indol-2-yl)-3-(1H-indol-2-yl)prop-2-en-1-one
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000008
(2E)-1-(6-bromo-1H-indol-2-yl)-3-(5-bromo-2-methoxyphenyl)prop-2-en-1-one
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000403
(2E)-3-(3-bromo-2-hydroxyphenyl)-1-(6-bromo-1H-indol-2-yl)prop-2-en-1-one
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000014
(2E)-3-(4-bromo-2-hydroxyphenyl)-1-(6-bromo-1H-indol-2-yl)prop-2-en-1-one
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.00178
(2E)-3-(5-bromo-1H-indol-3-yl)-1-(1H-indol-2-yl)prop-2-en-1-one
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000355
(2E)-3-(5-bromo-2-hydroxyphenyl)-1-(1H-indol-2-yl)prop-2-en-1-one
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000024
(2E)-3-(5-bromo-2-hydroxyphenyl)-1-(6-bromo-1H-indol-2-yl)prop-2-en-1-one
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000343
(2E)-3-(6-bromo-1H-indol-2-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.058
(2R,3S)-2-(3,4-diphenoxyphenyl)-3,5,7-triphenoxy-3,4-dihydro-2H-1-benzopyran
Homo sapiens
-
at pH 8.0 and 22°C
0.02
(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl (4-methylpiperidin-1-yl)carbamodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.00528
(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl 1,3-thiazolidine-3-carbodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.0117
(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl 3,5-dimethylmorpholine-4-carbodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.02
(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl 4-(propan-2-yl)piperazine-1-carbodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.02
(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl 4-acetylpiperazine-1-carbodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.01424
(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl 4-methylpiperazine-1-carbodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.00221
(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl benzylcarbamodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.02
(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl bis(2-hydroxyethyl)carbamodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.00508
(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl cyclohexyl(methyl)carbamodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.00457
(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl dibutylcarbamodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.00878
(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl diethylcarbamodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.01411
(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl diprop-2-en-1-ylcarbamodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.00679
(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl dipropylcarbamodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.02
(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl methylcarbamodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.01524
(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl morpholine-4-carbodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.02
(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl piperidin-1-ylcarbamodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.00295
(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl piperidine-1-carbodithioate
0.01973
(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl pyrrolidine-1-carbodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.00589
(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl thiomorpholine-4-carbodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.02
(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl [(pyridin-2-yl)methyl]carbamodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.02
(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl [(pyridin-3-yl)methyl]carbamodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.02
(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl [(pyridin-4-yl)methyl]carbamodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.02
(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl [2-(diethylamino)ethyl]carbamodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.0026
(6R,10S)-2-chloro-6,10-bis(5-chloro-1H-indol-3-yl)-5,6,7,8,9,10-hexahydrocyclohepta[b]indole
Staphylococcus aureus
-
precombinant enzyme, pH 7.5, 30°C
0.0025
(6R,10S)-3-chloro-6,10-bis(6-chloro-1H-indol-3-yl)-5,6,7,8,9,10-hexahydrocyclohepta[b]indole
Staphylococcus aureus
-
precombinant enzyme, pH 7.5, 30°C
0.0102
(6R,10S)-6,10-di(1H-indol-3-yl)-5,6,7,8,9,10-hexahydrocyclohepta[b]indole
Staphylococcus aureus
-
precombinant enzyme, pH 7.5, 30°C
0.0113
(6R,11S)-6,11-di(1H-indol-3-yl)-6,7,8,9,10,11-hexahydro-5H-cycloocta[b]indole
Staphylococcus aureus
-
precombinant enzyme, pH 7.5, 30°C
0.000015
(E)-5-bromo-2-hydroxy-N'-(1-(4,5,6-trifluoro-1Hindol-2-yl)ethylidene)benzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000214
(E)-5-bromo-2-hydroxy-N'-(1-(5-hydroxy-1H-indol-2-yl)ethylidene)benzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000178
(E)-5-bromo-2-hydroxy-N'-(1-(5-methoxy-1H-indol-2-yl)ethylidene)benzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000024
(E)-5-bromo-N'-(1-(4,5-difluoro-1H-indol-2-yl)ethylidene)-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.00002
(E)-5-bromo-N'-(1-(5,6-difluoro-1H-indol-2-yl)ethylidene)-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000049
(E)-5-bromo-N'-(1-(5-bromo-1H-indol-2-yl)ethylidene)-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000451
(E)-5-bromo-N'-(1-(5-bromo-1H-indol-2-yl)propylidene)-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000052
(E)-5-bromo-N'-(1-(5-chloro-1H-indol-2-yl)ethylidene)-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000049
(E)-5-bromo-N'-(1-(5-fluoro-1H-indol-2-yl)ethylidene)-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000024
(E)-5-bromo-N'-(1-(6-bromo-1H-indol-2-yl)ethylidene)-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000863
(E)-N'-((1H-indol-2-yl)methylene)-5-bromo-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000151
(E)-N'-(1-(1H-indol-2-yl)ethylidene)-2-hydroxy-5-iodobenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.008615
(E)-N'-(1-(1H-indol-2-yl)ethylidene)-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000074
(E)-N'-(1-(1H-indol-2-yl)ethylidene)-3,5-dibromo-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.00815
(E)-N'-(1-(1H-indol-2-yl)ethylidene)-3-bromobenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.001312
(E)-N'-(1-(1H-indol-2-yl)ethylidene)-4-bromo-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000064
(E)-N'-(1-(1H-indol-2-yl)ethylidene)-5-bromo-2-(prop-2-ynyloxy)benzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000324
(E)-N'-(1-(1H-indol-2-yl)ethylidene)-5-bromo-2-hydroxy-4-methoxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000085
(E)-N'-(1-(1H-indol-2-yl)ethylidene)-5-bromo-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000182
(E)-N'-(1-(1H-indol-2-yl)ethylidene)-5-bromo-2-methoxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000126
(E)-N'-(1-(1H-indol-2-yl)propylidene)-5-bromo-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000049
(E)-N'-[(1H-indol-2-yl)methylene]-5-bromo-2-methoxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000063
(E)-N'-[1-(1H-indol-2-yl)ethylidene]-5-bromo-2-ethoxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000445
(E/Z)-N'-((1H-indol-2-yl)(phenyl)methylene)-5-bromo-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.00001
1-(6-bromo-1H-indol-2-yl)-2-(4-bromophenyl)ethan-1-one
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000116
2-(3-bromo-2-hydroxyphenyl)-1-(6-bromo-1H-indol-2-yl)ethan-1-one
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000012
2-(4-bromophenyl)-1-(1H-indol-2-yl)ethan-1-one
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000003
2-(5-bromo-1H-benzimidazol-2-yl)-1-(5-bromo-1H-indol-2-yl)ethan-1-one
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000011
2-(5-bromo-1H-benzimidazol-2-yl)-1-(5-bromo-2-hydroxyphenyl)ethan-1-one
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000002
2-(5-bromo-1H-benzimidazol-2-yl)-1-(6-bromo-1H-indol-2-yl)ethan-1-one
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000011
2-(6-bromo-1,3-benzothiazol-2-yl)-1-(1H-indol-2-yl)ethan-1-one
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000043
2-(6-bromo-1,3-benzothiazol-2-yl)-1-(3-bromo-2-hydroxyphenyl)ethan-1-one
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000004
2-(6-bromo-1,3-benzothiazol-2-yl)-1-(3-chloro-2-hydroxyphenyl)ethan-1-one
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000214
2-(6-bromo-1,3-benzothiazol-2-yl)-1-(4-bromo-2-hydroxyphenyl)ethan-1-one
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000023
2-(6-bromo-1,3-benzothiazol-2-yl)-1-(5-bromo-1H-indol-2-yl)ethan-1-one
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000008
2-(6-bromo-1,3-benzothiazol-2-yl)-1-(5-bromo-2-methoxyphenyl)ethan-1-one
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000483
2-hydroxy-5-iodo-N'-[(1E)-1-(1-methyl-1H-indol-2-yl)ethylidene]benzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.145
3,5-diphenoxy-2-[(2E)-3-(3,4,5-triphenoxyphenyl)prop-2-en-1-yl]phenol
Homo sapiens
-
at pH 8.0 and 22°C
0.01
3-(2,5-dimethylphenoxy)-1,2-benzothiazole 1,1-dioxide
Leishmania mexicana
-
pH 7.2, 25°C
0.295
3-(2-hydroxy-4-methoxyphenyl)-1-(4-methoxyphenyl)propane-1,2-diol
Homo sapiens
-
at pH 8.0 and 22°C
0.000042
3-hydroxy-N'-[(1E)-1-(1H-indol-2-yl)ethylidene]naphthalene-2-carbohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000059
3-hydroxy-N'-[(1E)-1-(4,5,6-trifluoro-1-methyl-1H-indol-2-yl)ethylidene]naphthalene-2-carbohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000052
3-hydroxy-N'-[(1E)-1-(4,5,6-trifluoro-1-methyl-1H-indol-2-yl)propylidene]naphthalene-2-carbohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000031
3-hydroxy-N'-[(1E)-1-(4,5,6-trifluoro-1H-indol-2-yl)propylidene]naphthalene-2-carbohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.02
3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl 4-acetylpiperazine-1-carbodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.00998
3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl dipropylcarbamodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.0085
3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl morpholine-4-carbodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.00493
3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl piperidine-1-carbodithioate
Homo sapiens
recombinant His-tagged enzyme, pH 7.5, 37°C
0.005
3-[(2,5-dimethylphenyl)sulfanyl]-1,2-benzothiazole 1,1-dioxide
Leishmania mexicana
-
pH 7.2, 25°C
0.028 - 0.191
4-amino-2-methylnaphthalen-1-ol
0.045
5,7-diphenoxy-2-(3,4,5-triphenoxyphenyl)-2H-1-benzopyran
Homo sapiens
-
at pH 8.0 and 22°C
0.01
5-(2,5-dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic acid
Homo sapiens
-
in 50 mM Tris, pH 7.5, at 22°C
0.000251
5-bromo-2-(ethoxymethoxy)-N'-((1E)-1-(1H-indol-2-yl)ethylidene)benzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000841
5-bromo-2-hydroxy-4-methoxy-N'-[(1E)-1-(1-methyl-1H-indol-2-yl)ethylidene]benzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000227
5-bromo-2-hydroxy-N'-[(1E)-1-(1-methyl-1H-benzimidazol-2-yl)ethylidene]benzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000381
5-bromo-2-hydroxy-N'-[(1E)-1-(1-methyl-1H-indol-2-yl)ethylidene]benzohydrazide
0.000461
5-bromo-2-hydroxy-N'-[(1E)-1-(1-methyl-1H-indol-2-yl)propylidene]benzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000084
5-bromo-2-hydroxy-N'-[(1E)-1-(1H-indol-2-yl)ethylidene]benzohydrazide
Staphylococcus aureus
-
pH not specified in the publication, 30°C
0.000114
5-bromo-2-hydroxy-N'-[(1E)-1-(1H-indol-2-yl)propylidene]benzohydrazide
Staphylococcus aureus
-
pH not specified in the publication, 30°C
0.000055
5-bromo-2-hydroxy-N'-[(1E)-1-(4,5,6-trifluoro-1-methyl-1H-indol-2-yl)ethylidene]benzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000043
5-bromo-2-hydroxy-N'-[(1E)-1-(5-iodo-1H-indol-2-yl)ethylidene]benzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000794
5-bromo-2-hydroxy-N'-[(1E)-1-(5-methoxy-1-methyl-1H-indol-2-yl)ethylidene]benzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.006043
5-bromo-2-hydroxy-N'-[(E)-(1-methyl-1H-indol-2-yl)(phenyl)methylidene]benzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.003087
5-bromo-2-hydroxy-N'-[(E)-(1-methyl-1H-indol-2-yl)methylidene]benzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000145
5-bromo-N'-[(1E)-1-(4,5-difluoro-1-methyl-1H-indol-2-yl)ethylidene]-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000061
5-bromo-N'-[(1E)-1-(5,6-difluoro-1-methyl-1H-indol-2-yl)ethylidene]-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000016
5-bromo-N'-[(1E)-1-(5,6-difluoro-1H-indol-2-yl)ethylidene]-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH not specified in the publication, 30°C
0.000146
5-bromo-N'-[(1E)-1-(5-bromo-1-methyl-1H-indol-2-yl)ethylidene]-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000168
5-bromo-N'-[(1E)-1-(5-bromo-1-methyl-1H-indol-2-yl)propylidene]-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000228
5-bromo-N'-[(1E)-1-(5-chloro-1-methyl-1H-indol-2-yl)ethylidene]-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000165
5-bromo-N'-[(1E)-1-(5-fluoro-1-methyl-1H-indol-2-yl)ethylidene]-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000017
5-bromo-N'-[(1E)-1-(6-bromo-1-methyl-1H-indol-2-yl)ethylidene]-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000228
5-bromo-N'-[(1E)-1-(6-chloro-1-methyl-1H-indol-2-yl)ethylidene]-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH not specified in the publication, 30°C
0.000165
5-bromo-N'-[(1E)-1-(6-fluoro-1-methyl-1H-indol-2-yl)ethylidene]-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH not specified in the publication, 30°C
0.000045
5-bromo-N'-[(1E)-1-(6-fluoro-1H-indol-2-yl)ethylidene]-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH not specified in the publication, 30°C
0.000008
5-bromo-N-(5-bromo-1,3-benzothiazol-2-yl)-1H-indole-2-carboxamide
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000003
5-bromo-N-(6-bromo-1,3-benzothiazol-2-yl)-2-hydroxybenzamide
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000102
6-bromo-3-(4-bromophenyl)-1H-indole
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.8 - 13.7
ATP
0.00006
bromodeoxytopsentin
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000016
cis-3-4-dihydrohamacanthin B
Staphylococcus aureus
-
pH and temperature not specified in the publication
3.64 - 14.2
citrate
8
D-fructose 1,6-bisphosphate
Ricinus communis
-
IC50: 8.4 mM at pH 6.4, IC50: 8.0 mM at pH 7.4
17.2
diphosphate
Ricinus communis
-
IC50: 9.8 mM at pH 6.4, IC50: 17.2 mM at pH 7.4
1.2
glutamate
Ricinus communis
-
IC50: 2.5 mM at pH 6.4, IC50: 1.2 mM at pH 7.4
130 - 550
guanidine hydrochloride
51 - 433
KCl
0.01 - 0.1
L-alanine
6.2
L-glutamate
34.4 - 187
Lactate
0.15 - 3.407
menadione
0.000224
N'-[(1E)-1-(1,3-benzothiazol-2-yl)ethylidene]-5-bromo-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000286
N'-[(1E)-1-(1-benzothiophen-2-yl)ethylidene]-5-bromo-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000091
N'-[(1E)-1-(1H-benzimidazol-2-yl)ethylidene]-5-bromo-2-hydroxybenzohydrazide
0.000126
N'-[(1E)-1-(1H-benzimidazol-2-yl)propylidene]-5-bromo-2-hydroxybenzohydrazide
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000115
N'-[(1E)-1-(5-bromo-1-methyl-1H-indol-2-yl)ethylidene]-3-hydroxynaphthalene-2-carbohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000079
N'-[(1E)-1-(5-bromo-1-methyl-1H-indol-2-yl)propylidene]-3-hydroxynaphthalene-2-carbohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000026
N'-[(1E)-1-(5-bromo-1H-indol-2-yl)ethylidene]-3-hydroxynaphthalene-2-carbohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.000018
N'-[(1E)-1-(5-bromo-1H-indol-2-yl)propylidene]-3-hydroxynaphthalene-2-carbohydrazide
Staphylococcus aureus
-
pH 7.5, 30°C
0.00091
N'-[(3Z)-1-ethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]-3-hydroxynaphthalene-2-carbohydrazide
Staphylococcus aureus
-
pH not specified in the publication, 30°C
0.0593 - 0.0775
N-(3-carboxy-4-hydroxy)phenyl-2,5-dimethylpyrrole
0.000051
N-(5-bromo-1,3-benzothiazol-2-yl)-1H-indole-2-carboxamide
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.149 - 0.41
oxalate
0.00882
shikonin
600 - 1980
Urea
0.02
[(5Z)-5-(4-[[(2-iodophenyl)carbonyl]oxy]benzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
Homo sapiens
-
in 50 mM Tris, pH 7.5, at 22°C