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2.7.1.40: pyruvate kinase

This is an abbreviated version!
For detailed information about pyruvate kinase, go to the full flat file.

Word Map on EC 2.7.1.40

Reaction

ATP
+
pyruvate
=
ADP
 +
phosphoenolpyruvate

Synonyms

ATP/pyruvate O'-phosphotransferase, ATP:pyruvate 2-O-phosphotransferase, CPK, CPK1, cPK2, cPK3, cPK4, cPK5, CTHBP, cytosolic pyruvate kinase, cytosolic thyroid hormone binding protein, EHI_098420, EhPK, EhPyk, erythroid (R-type) pyruvate kinase, fluorokinase, hL-PYK, hLPYK, hPKM2, K+-dependent PK, K+-independent PK, kinase, fluoro- (phosphorylating), kinase, pyruvate (phosphorylating), L-PK , L-PYK, liver PK, liver pyruvate kinase, M1-PK, M1-PYK, M2 pyruvate kinase, M2 type phosphoenolpyruvate kinase, M2-PK, M2-pyruvate kinase, M2-type pyruvate kinase, M2PK, mPKM2, MRSA PK, muscle PK, NCgl2008, NCgl2809, PAE0819, PfPYK, pfPyrK, phosphoenol transphosphorylase, phosphoenolpyruvate kinase, phosphoenolpyruvate: ADP phosphotransferase, PK-alphabeta1, PK-alphabeta2, PK-M1, PK-M2, PK-R, PK-S, PK1, PK3, PKC, PKC1, PKL, Pklr, PKM1, PKM2, PKp, ProTalphaK, PYK, PYK-I, Pyk1, Pyk2, PykA, PykF, PyKII, pyruvate kinase, pyruvate kinase 1, pyruvate kinase isoenzyme M2, pyruvate kinase isoform M2, pyruvate kinase isoforms 2, pyruvate kinase isozyme M1, pyruvate kinase isozyme type M2, pyruvate kinase M1, pyruvate kinase M2, pyruvate kinase M2 isoform, pyruvate kinase muscle isoform 2, pyruvate kinase muscle isozyme, pyruvate kinase type M2, pyruvate kinase type-II, pyruvate phosphotransferase, pyruvic kinase, R-type pyruvate kinase, R-type/L-type pyruvate kinase, red cell/liver pyruvate kinase, rM1-PYK, RMPK, RPK, Rv1617, SSO0981, TbrPYK, TCIL3000_10_12020, TcoPYK, THBP1, TuM2-PK, tumor cell specific pyruvate kinase isozyme M2, tumour M2-PK, tumour M2-pyruvate kinase, VcIIPK, VcIPK, VC_0485, VC_2008, VEG17, vegetative protein 17, vesicle-associated pyruvate kinase, YPK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.40 pyruvate kinase

pH Range

pH Range on EC 2.7.1.40 - pyruvate kinase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4 - 10
activity range, inactive below and above, the enzyme exhibits 73% and 29% at pH 7.0 and pH 8.0, respectively, compared to the maximal activity at pH 7.5
4 - 6.8
-
increase of activity in this range, decline at higher pH-values
5 - 8.25
-
-
5.2 - 8
-
isozyme PKp, about half-maximal activity at pH 5.2 and pH 8
5.5 - 7
-
about 30% of maximal activity at pH 5.5 and 7.0
5.5 - 7.4
-
60°C, about half-maximal activity at pH 5.5 and pH 7.4
5.5 - 7.5
5.7 - 8.5
-
1.25 mM phosphoenolpyruvate, about half-maximal activity at pH 5.7 and 8.5, about 80% of maximal activity at pH 7.4
5.9 - 8.2
-
isozyme PKc, about half-maximal activity at pH 5.9 and pH 8.2
6 - 7.3
-
0.125 mM phosphoenolpyruvate, about half-maximal activity at pH 6 and pH 7.3
6 - 8
Busycotypus canaliculatum
-
about 70% of maximal activity at pH 6 and about half-maximal activity at pH 8
6 - 8.3
-
isozyme PKc, about half-maximal activity at pH 6 and pH 8.3
6 - 9
over 80% of maximal activity within this range, profile overview
6.4 - 8.2
-
30°C, about half-maximal activity at pH 6.4 and pH 8.2
7.2 - 8.3
-
isozyme Pkp, about half-maximal activity at pH 7.2 and pH 8.3
8 - 9.5
additional information