2.7.1.43: glucuronokinase
This is an abbreviated version!
For detailed information about glucuronokinase, go to the full flat file.
Word Map on EC 2.7.1.43
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2.7.1.43
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glucuronic
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pyrophosphorylase
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pollen
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udp-sugar
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udp-glucuronic
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myo-inositol
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lilium
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sugar-1-phosphates
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longiflorum
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utp
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diagnostics
- 2.7.1.43
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glucuronic
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pyrophosphorylase
- pollen
- udp-sugar
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udp-glucuronic
- myo-inositol
- lilium
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sugar-1-phosphates
- longiflorum
- utp
- diagnostics
Reaction
Synonyms
At3g01640, AtGlcAK, AtGlcAK2, GKUP, GlcAK, GlcAK1, GlcAK2, glucuronokinase, glucuronokinase 1, glucuronokinase 2, glucuronokinase, glucurono-, glucuronokinase1, kinase, glucurono- (phosphorylating)
ECTree
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General Information
General Information on EC 2.7.1.43 - glucuronokinase
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evolution
malfunction
metabolism
physiological function
evolution
glucuronokinase is a member of the GHMP-kinase superfamily
GlcAK1 knockout mutant phenotype of T-DNA insertional mutants glcak1-1, glcak1-2, glcak1-3, and glcak1-4, overview
malfunction
there is reduced primary root elongation and lateral root formation in atglcak mutants under osmotic stress. The atglcak mutants display enhanced stomatal opening in response to abscisic acid (ABA), elevated water loss, and impaired drought tolerance. Under water stress, the accumulation of reducing and soluble sugars is reduced in atglcak mutants, and the metabolism of glucose and sucrose is affected by the synthetic pathway of UDP-GlcA. Furthermore, a reduced level of starch in atglcak mutants is observed under normal conditions
malfunction
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GlcAK1 knockout mutant phenotype of T-DNA insertional mutants glcak1-1, glcak1-2, glcak1-3, and glcak1-4, overview
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malfunction
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there is reduced primary root elongation and lateral root formation in atglcak mutants under osmotic stress. The atglcak mutants display enhanced stomatal opening in response to abscisic acid (ABA), elevated water loss, and impaired drought tolerance. Under water stress, the accumulation of reducing and soluble sugars is reduced in atglcak mutants, and the metabolism of glucose and sucrose is affected by the synthetic pathway of UDP-GlcA. Furthermore, a reduced level of starch in atglcak mutants is observed under normal conditions
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the enzyme is involved in the the myo-inositol oxygenase pathway to nucleotide sugars, as part of the nucleotide sugar interconversion pathway, overview
metabolism
the enzyme is involved in the the myo-inositol oxygenase pathway to nucleotide sugars, as part of the nucleotide sugar interconversion pathway, overview
metabolism
one alternative pathway for ascorbic acid (AsA) synthesis, which is similar to the biosynthesis route in mammals, is controversially discussed for plants. Pathway overview for AsA biosynthesis in plants, overview. Here, myo-inositol is cleaved to glucuronic acid and then converted via L-gulonate to AsA. In contrast to animals, plants have an effective recycling pathway for glucuronic acid, being a competitor for the metabolic rate. Recycling involves a phosphorylation at C1 by the enzyme glucuronokinase
metabolism
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one alternative pathway for ascorbic acid (AsA) synthesis, which is similar to the biosynthesis route in mammals, is controversially discussed for plants. Pathway overview for AsA biosynthesis in plants, overview. Here, myo-inositol is cleaved to glucuronic acid and then converted via L-gulonate to AsA. In contrast to animals, plants have an effective recycling pathway for glucuronic acid, being a competitor for the metabolic rate. Recycling involves a phosphorylation at C1 by the enzyme glucuronokinase
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nucleotide sugars are building blocks for carbohydrate polymers in plant cell walls, the main precursor for primary cell walls is UDP-glucuronic acid, which can be synthesized via two independent pathways. One starts with the ring cleavage of myo-inositol into glucuronic acid, which requires a glucuronokinase and a pyrophosphorylase for activation into UDP-glucuronate
physiological function
nucleotide sugars are building blocks for carbohydrate polymers in plant cell walls, the main precursor for primary cell walls is UDP-glucuronic acid, which can be synthesized via two independent pathways. One starts with the ring cleavage of myo-inositol into glucuronic acid, which requires a glucuronokinase and a pyrophosphorylase for activation into UDP-glucuronate
physiological function
isozyme glucuronokinase 1 gene, AtGlcAK, in Arabidopsis thaliana is involved in drought tolerance by modulating sugar metabolism
physiological function
isozyme glucuronokinase 1 gene, AtGlcAK, in Arabidopsis thaliana is involved in drought tolerance by modulating sugar metabolism and in abscisic acid-mediated stomata movement. AtGlcAK is implicated in carbohydrate metabolism and regulates the synthesis of glucose and sucrose which served as signaling molecules to regulate gene expressions, development and adaption to environmental stress factors
physiological function
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isozyme glucuronokinase 1 gene, AtGlcAK, in Arabidopsis thaliana is involved in drought tolerance by modulating sugar metabolism and in abscisic acid-mediated stomata movement. AtGlcAK is implicated in carbohydrate metabolism and regulates the synthesis of glucose and sucrose which served as signaling molecules to regulate gene expressions, development and adaption to environmental stress factors
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physiological function
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isozyme glucuronokinase 1 gene, AtGlcAK, in Arabidopsis thaliana is involved in drought tolerance by modulating sugar metabolism
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