2.7.1.45: 2-dehydro-3-deoxygluconokinase

This is an abbreviated version!
For detailed information about 2-dehydro-3-deoxygluconokinase, go to the full flat file.

Reaction

Synonyms

2-dehydrogluconokinase, 2-keto-3-deoxy-D-gluconate kinase, 2-keto-3-deoxy-D-gluconic acid kinase, 2-keto-3-deoxygluconate kinase, 2-keto-3-deoxygluconokinase, 2-ketogluconate kinase, FlKin, HVO_0549, KDG kinase, KDGK, KDGK-1, ketodeoxygluconokinase, KGUK, KGUKCnec, kinase, 2-keto-3-deoxyglucono- (phosphorylating), More, Ta0122, TM0067

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.45 2-dehydro-3-deoxygluconokinase

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Results	in table
3191	AA Sequence
1	CAS Registry Number
8	Cloned(Commentary)
6	Cofactor
4	Crystallization (Commentary)
8	General Information
1	General Stability
1	Inhibitors
13	KM Value [mM]
22	Metals/Ions
13	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
105	Organism
15	Pathway
22	PDB ID
11	pH Optimum
2	pH Range
3	pH Stability
1	pI Value
1	Posttranslational Modification
3	Protein Variants
10	Purification (Commentary)
4	Reaction
1	Reaction Type
17	Reference
2	Source Tissue
8	Specific Activity [micromol/min/mg]
1	Storage Stability
37	Substrates and Products (Substrate)
12	Subunits
32	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Range [°C]
8	Temperature Stability [°C]
6	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.7.1.45 - 2-dehydro-3-deoxygluconokinase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

ATP + 2-dehydro-3-deoxy-D-gluconate

ADP + 2-dehydro-3-deoxy-6-phospho-D-gluconate

3 entries

ATP + 2-dehydro-3-deoxy-D-gluconate

ADP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

9 entries

ATP + 2-keto-D-gluconate

ADP + 6-phospho-2-keto-D-gluconate

3 entries

CTP + 2-dehydro-3-deoxy-D-gluconate

CDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

2 entries

GTP + 2-dehydro-3-deoxy-D-gluconate

GDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

4 entries

ITP + 2-dehydro-3-deoxy-D-gluconate

IDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

4 entries

TTP + 2-dehydro-3-deoxy-D-gluconate

TDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

2 entries

UTP + 2-dehydro-3-deoxy-D-gluconate

UDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

2 entries

additional information

?

-

11 entries

ATP + 2-dehydro-3-deoxy-D-gluconate

ADP + 2-dehydro-3-deoxy-6-phospho-D-gluconate

Cupriavidus necator

Q0K080

-

759808

-

-

r

ATP + 2-dehydro-3-deoxy-D-gluconate

ADP + 2-dehydro-3-deoxy-6-phospho-D-gluconate

Flavobacterium sp. UMI-01

A0A0B6VMB0

-

759703

-

-

?

ATP + 2-dehydro-3-deoxy-D-gluconate

ADP + 2-dehydro-3-deoxy-6-phospho-D-gluconate

Haloferax volcanii

D4GSE6

-

738267

-

-

?

ATP + 2-dehydro-3-deoxy-D-gluconate

ADP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

Escherichia coli

-

-

636960

-

636960

?

ATP + 2-dehydro-3-deoxy-D-gluconate

ADP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

Escherichia coli

-

-

636961

-

-

?

ATP + 2-dehydro-3-deoxy-D-gluconate

ADP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

Escherichia coli

-

enzyme is induced by galacturonate or glucuronate and is controlled by a single structural gene

636961

-

-

?

ATP + 2-dehydro-3-deoxy-D-gluconate

ADP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

Klebsiella aerogenes

-

-

636960

-

636960

?

ATP + 2-dehydro-3-deoxy-D-gluconate

ADP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

Sulfurisphaera tokodaii

Q96XN9

-

676988

-

-

?

ATP + 2-dehydro-3-deoxy-D-gluconate

ADP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

Thermoplasma acidophilum

-

-

672718

-

-

?

ATP + 2-dehydro-3-deoxy-D-gluconate

ADP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

Thermus thermophilus

-

-

657469

-

-

?

ATP + 2-dehydro-3-deoxy-D-gluconate

ADP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

Thermus thermophilus

-

preferred substrate, binding mechanism and structure, overview

659714

-

-

?

ATP + 2-dehydro-3-deoxy-D-gluconate

ADP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

Thermus thermophilus HB8 / ATCC 27634 / DSM 579

-

preferred substrate, binding mechanism and structure, overview

659714

-

-

?

ATP + 2-keto-D-gluconate

ADP + 6-phospho-2-keto-D-gluconate

Sulfurisphaera tokodaii

Q96XN9

-

676988

-

-

?

ATP + 2-keto-D-gluconate

ADP + 6-phospho-2-keto-D-gluconate

Thermus thermophilus

-

-

659714

-

-

?

ATP + 2-keto-D-gluconate

ADP + 6-phospho-2-keto-D-gluconate

Thermus thermophilus HB8 / ATCC 27634 / DSM 579

-

-

659714

-

-

?

CTP + 2-dehydro-3-deoxy-D-gluconate

CDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

Escherichia coli

-

8% of the activity with ATP

636960

-

-

?

CTP + 2-dehydro-3-deoxy-D-gluconate

CDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

Klebsiella aerogenes

-

8% of the activity with ATP

636960

-

-

?

GTP + 2-dehydro-3-deoxy-D-gluconate

GDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

Escherichia coli

-

34% of the activity with ATP

636960

-

-

?

GTP + 2-dehydro-3-deoxy-D-gluconate

GDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

Klebsiella aerogenes

-

34% of the activity with ATP

636960

-

-

?

GTP + 2-dehydro-3-deoxy-D-gluconate

GDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

Sulfurisphaera tokodaii

Q96XN9

94% activity compared to the substrate combination with ATP

676988

-

-

?

GTP + 2-dehydro-3-deoxy-D-gluconate

GDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

Sulfurisphaera tokodaii

Q96XN9

94% of the activity with ATP

676988

-

-

?

ITP + 2-dehydro-3-deoxy-D-gluconate

IDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

Escherichia coli

-

75% of the activity with ATP

636960

-

-

?

ITP + 2-dehydro-3-deoxy-D-gluconate

IDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

Klebsiella aerogenes

-

75% of the activity with ATP

636960

-

-

?

ITP + 2-dehydro-3-deoxy-D-gluconate

IDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

Sulfurisphaera tokodaii

Q96XN9

66% activity compared to the substrate combination with ATP

676988

-

-

?

ITP + 2-dehydro-3-deoxy-D-gluconate

IDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

Sulfurisphaera tokodaii

Q96XN9

66% of the activity with ATP

676988

-

-

?

TTP + 2-dehydro-3-deoxy-D-gluconate

TDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

Sulfurisphaera tokodaii

Q96XN9

43% activity compared to the substrate combination with ATP

676988

-

-

?

TTP + 2-dehydro-3-deoxy-D-gluconate

TDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

Sulfurisphaera tokodaii

Q96XN9

43% of the activity with ATP

676988

-

-

?

UTP + 2-dehydro-3-deoxy-D-gluconate

UDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

Escherichia coli

-

7% of the activity with ATP

636960

-

-

?

UTP + 2-dehydro-3-deoxy-D-gluconate

UDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

Klebsiella aerogenes

-

7% of the activity with ATP

636960

-

-

?

additional information

?

-

Cupriavidus necator

Q0K080

the substrate specificity analysis reveals that three ketoacids (2-dehydro-3-deoxy-D-gluconate, 2-dehydro-D-gulonate, and 2-dehydro-3-deoxy-D-gulonate) with structures close to the natural substrate (2-dehydro-D-gluconate) are successfully phosphorylated at an efficiency lower than or comparable to 2-dehydrogluconate, as depicted by the measured kinetic constant values. Assay method optimization, overview

759808

-

-

-

additional information

?

-

Cupriavidus necator

-

the substrate specificity analysis reveals that three ketoacids (2-dehydro-3-deoxy-D-gluconate, 2-dehydro-D-gulonate, and 2-dehydro-3-deoxy-D-gulonate) with structures close to the natural substrate (2-dehydro-D-gluconate) are successfully phosphorylated at an efficiency lower than or comparable to 2-dehydrogluconate, as depicted by the measured kinetic constant values. Assay method optimization, overview

759808

-

-

-

additional information

?

-

Escherichia coli

-

no substrate: 2-deoxy-D-ribose, 2-deoxy-D-glucose, D-gluconate, 2-keto-D-gluconate, 2-oxoglutarate, 2-oxo-3-deoxy-6-phosphogluconate

636961

-

-

?

additional information

?

-

Flavobacterium sp. UMI-01

A0A0B6VMB0

thin-layer chromatography (TLC) and mass spectrometric analyses of reaction products of recombinant FlKin

759703

-

-

-

additional information

?

-

Sulfurisphaera tokodaii

-

does not accept ADP or AMP as phosphoryl donors

676988

-

-

?

additional information

?

-

Sulfurisphaera tokodaii

Q96XN9

does not accept ADP or AMP as phosphoryl donors

676988

-

-

?

additional information

?

-

Sulfurisphaera tokodaii

-

no substrate: UTP, CTP, ADP, GDP, IDP, UDP, CDP, and AMP, D-glucose, D-fructose, and 2-keto-3-deoxyoctonate

676988

-

-

?

additional information

?

-

Sulfurisphaera tokodaii

Q96XN9

no substrate: UTP, CTP, ADP, GDP, IDP, UDP, CDP, and AMP, D-glucose, D-fructose, and 2-keto-3-deoxyoctonate

676988

-

-

?

additional information

?

-

Thermoplasma acidophilum

-

D-gluconate, 2-keto-D-gluconate, 5-keto-D-gluconate, N-acetylglucosamine, and D-xylose are no substrates

672718

-

-

?

additional information

?

-

Thermus thermophilus

-

enzyme shows high substrate specificity, no activity with glucose, fructose, ribose, xylitol, gluconate, and gluconic acid lactone

659714

-

-

?

additional information

?

-

Thermus thermophilus HB8 / ATCC 27634 / DSM 579

-

enzyme shows high substrate specificity, no activity with glucose, fructose, ribose, xylitol, gluconate, and gluconic acid lactone

659714

-

-

?