2.7.1.48: uridine/cytidine kinase

This is an abbreviated version!
For detailed information about uridine/cytidine kinase, go to the full flat file.

Reaction

Synonyms

ATP:uridine 5'-phosphotransferase, hsUCK2, kinase, uridine (phosphorylating), More, pyrimidine ribonucleoside kinase, ttCK, UCK, UCK1, UCK2, UCKL1, Udk, UK/UPRT1, uridine cytidine kinase 2, uridine kinase, uridine phosphokinase, uridine-cytidine kinase, uridine-cytidine kinase 2, uridine/cytidine kinase, uridine/cytidine kinase 2

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.48 uridine/cytidine kinase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
3	Activating Compound
21722	AA Sequence
8	Application
1	CAS Registry Number
24	Cloned(Commentary)
13	Cofactor
7	Crystallization (Commentary)
298	Disease/ Diagnostics
3	Expression
39	General Information
7	General Stability
12	IC50 Value
64	Inhibitors
36	kcat/KM [mM/s]
8	Ki Value [mM]
92	KM Value [mM]
6	Localization
49	Metals/Ions
19	Molecular Weight [Da]
68	Natural Substrates/ Products (Substrates)
167	Organism
7	Pathway
48	PDB ID
19	pH Optimum
1	pH Range
1	pH Stability
44	Protein Variants
25	Purification (Commentary)
7	Reaction
1	Reaction Type
62	Reference
102	Source Tissue
13	Specific Activity [micromol/min/mg]
12	Storage Stability
272	Substrates and Products (Substrate)
21	Subunits
71	Synonyms
1	Systematic Name
17	Temperature Optimum [°C]
8	Temperature Stability [°C]
32	Turnover Number [1/s]

Crystallization

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Crystallization on EC 2.7.1.48 - uridine/cytidine kinase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide Go to Crystallization (commentary) Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

analysis of cytidine-complex structure of hsUCK2 (PDB ID 1UEJ)

Homo sapiens

Q9BZX2

758717

crystals of uridine kinase 2 and in complex with CTP, UTP, cytidine, ATPgammaS and with both cytidine and ATP, the latter complex diffracted to 1.8 A resolution

Homo sapiens

Q9BZX2

641656

in complex with Mg2+, ADP, and CMP by sitting drop vapor diffusion method

Homo sapiens

Q9BZX2

660609

truncated form of UCK2 (1-250) in complex with substrates or feedback inhibitors UTP and CTP

Homo sapiens

Q9BZX2

663411

in complex with cytidine and beta,gamma-methyleneadenosine 5'-triphosphate, sitting drop vapor diffusion method, using 0.1 M NaCl, 0.1 M bicine, pH 9.0, and 20% (w/v) polyethylene glycol monomethyl ether 550

Thermus thermophilus

Q5SKR5

739594

purified recombinant enzyme H93Y variant ttCK free or incomplex with CMP, sitting-drop vapor diffusion method, mixing of 500 nl of 25 mg/ml protein, with 1 mM CMP, 1 mM ADP, and 1 mM MgCl2 in case of the enzyme complex, with 500 nl well solution containing 67% 40% v/v isopropanol, 15% w/v PEG 8000, and 0.1 M imidazole, pH 6.5, and 33% distilled water for the free enzyme, and containing 50% w/v PEG 200, and 0.1 M Tris-HCl, pH 8.0, for the enzyme complex, 20°C, X-ray diffraction structure determination and analysis at 2.25 A resolution, molecular replacement

Thermus thermophilus

Q5SKR5

721643

purified recombinant Y93H ttCK in complex with cytidine and AMPPCP, X-ray diffraction structure determination and analysis at 2.49 A resolution

Thermus thermophilus

Q5SKR5

758717