2.7.1.48: uridine/cytidine kinase
This is an abbreviated version!
For detailed information about uridine/cytidine kinase, go to the full flat file.
Word Map on EC 2.7.1.48
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2.7.1.48
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thymidine
-
salvage
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uracil
-
phosphoribosyltransferase
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phosphorylase
-
orotate
-
ump
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5-fluorouracil
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5-fluorouridine
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deoxycytidine
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5-azacytidine
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6-azauridine
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3-deazauridine
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orotidine
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pyrazofurin
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medicine
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5-fluoro-2'-deoxyuridine
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3huridine
-
dihydrouracil
-
drug development
-
diagnostics
-
biotechnology
- 2.7.1.48
- thymidine
-
salvage
- uracil
-
phosphoribosyltransferase
- phosphorylase
- orotate
- ump
- 5-fluorouracil
- 5-fluorouridine
- deoxycytidine
- 5-azacytidine
- 6-azauridine
- 3-deazauridine
- orotidine
- pyrazofurin
- medicine
- 5-fluoro-2'-deoxyuridine
-
3huridine
- dihydrouracil
- drug development
- diagnostics
- biotechnology
Reaction
Synonyms
ATP:uridine 5'-phosphotransferase, hsUCK2, kinase, uridine (phosphorylating), More, pyrimidine ribonucleoside kinase, ttCK, UCK, UCK1, UCK2, UCKL1, Udk, UK/UPRT1, uridine cytidine kinase 2, uridine kinase, uridine phosphokinase, uridine-cytidine kinase, uridine-cytidine kinase 2, uridine/cytidine kinase, uridine/cytidine kinase 2
ECTree
2.7.1.48 uridine/cytidine kinaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.7.1.48 - uridine/cytidine kinase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine
ADP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine 5'-phosphate
-
UCK2 enzyme activity required to produce the antitumoral active metabolite
-
-
?
ATP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine
ADP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine 5'-phosphate
-
UCK2 enzyme activity required to produce the antitumoral active metabolite
-
-
?
additional information
?
-
-
uridine kinase and uridine phosphorylase are involved in the homeostatic regulation of purine and pyrimidine metabolism in brain. At relatively low UTP and CTP level, uptaken uridine is mainly anabolized to uridine nucleotides. At relatively high UTP and CTP levels, the inhibition of uridine kinase channels uridine towards phosphorolysis, resulting in 5-phosphoribosyl-1-bisphosphate used for purine salvage synthesis
-
-
?
ATP + 3'-C-ethynylcytidine
ADP + 3'-C-ethynylcytidine 5'-phosphate
i.e. 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine
-
-
ir
ATP + 3'-C-ethynylcytidine
ADP + 3'-C-ethynylcytidine 5'-phosphate
-
i.e. 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine
-
-
ir
ATP + 3'-C-ethynylcytidine 5'-diphosphate
ADP + 3'-C-ethynylcytidine 5'-triphosphate
-
-
-
?
ATP + 3'-C-ethynylcytidine 5'-diphosphate
ADP + 3'-C-ethynylcytidine 5'-triphosphate
-
-
-
-
?
ATP + 3'-C-ethynylcytidine 5'-phosphate
ADP + 3'-C-ethynylcytidine 5'-diphosphate
-
-
-
?
ATP + 3'-C-ethynylcytidine 5'-phosphate
ADP + 3'-C-ethynylcytidine 5'-diphosphate
-
-
-
-
?
ATP + 3'-C-ethynyluridine
ADP + 3'-C-ethynyluridine 5'-phosphate
i.e. 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine
-
-
?
ATP + 3'-C-ethynyluridine
ADP + 3'-C-ethynyluridine 5'-phosphate
-
i.e. 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine
-
-
?
ATP + 3'-C-ethynyluridine 5'-diphosphate
ADP + 3'-C-ethynyluridine 5'-triphosphate
-
-
-
?
ATP + 3'-C-ethynyluridine 5'-diphosphate
ADP + 3'-C-ethynyluridine 5'-triphosphate
-
-
-
-
?
ATP + 3'-C-ethynyluridine 5'-phosphate
ADP + 3'-C-ethynyluridine 5'-diphosphate
-
-
-
?
ATP + 3'-C-ethynyluridine 5'-phosphate
ADP + 3'-C-ethynyluridine 5'-diphosphate
-
-
-
-
?
ATP + cytidine
ADP + CMP
-
rate limiting enzyme of the pyrimidine-nucleotide salvage pathway
-
-
?
ATP + cytidine
ADP + CMP
rate limiting enzyme of the pyrimidine-nucleotide salvage pathway
-
-
?
ATP + cytidine
ADP + CMP
rate limiting enzyme of the pyrimidine-nucleotide salvage pathway, essential for cell proliferation, UCK 2 involved in tumor formation
-
-
?
ATP + cytidine
ADP + CMP
the enzyme is responsible for the phosphorylation of uridine and cytidine to their corresponding monophosphate in a salvage pathway of pyrimidine nucleotides biosynthesis
-
-
?
ATP + cytidine
ADP + CMP
-
rate limiting enzyme of the pyrimidine-nucleotide salvage pathway
-
-
?
ATP + uridine
ADP + UMP
-
first enzyme of pyrimidine salvage pathway
-
?
ATP + uridine
ADP + UMP
-
rate limiting enzyme of the pyrimidine-nucleotide salvage pathway
-
-
?
ATP + uridine
ADP + UMP
rate limiting enzyme of the pyrimidine-nucleotide salvage pathway
-
-
?
ATP + uridine
ADP + UMP
rate limiting enzyme of the pyrimidine-nucleotide salvage pathway, essential for cell proliferation, UCK 2 involved in tumor formation
-
-
?
ATP + uridine
ADP + UMP
the enzyme is responsible for the phosphorylation of uridine and cytidine to their corresponding monophosphate in a salvage pathway of pyrimidine nucleotides biosynthesis
-
-
?
ATP + uridine
ADP + UMP
-
enzyme is part of the anabolic pathway by which the preformed pyrimidine nucleosides are salvaged for nucleic acid biosynthesis
-
?
ATP + uridine
ADP + UMP
-
rate limiting enzyme of pyrimidine salvage pathway
-
?
ATP + uridine
ADP + UMP
-
rate-limiting enzyme in anabolism of uridine and cytidine
-
?
ATP + uridine
ADP + UMP
-
rate limiting enzyme of the pyrimidine-nucleotide salvage pathway
-
-
?
ATP + uridine
ADP + UMP
-
first enzyme of pyrimidine salvage pathway
-
?
ATP + uridine
ADP + UMP
substrate of mutant ttCKs Y93H and Y93Q, not of wild-type ttCK Y93
-
-
?
ATP + uridine
ADP + UMP
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
substrate of mutant ttCKs Y93H and Y93Q, not of wild-type ttCK Y93
-
-
?
