2.7.1.49: hydroxymethylpyrimidine kinase
This is an abbreviated version!
For detailed information about hydroxymethylpyrimidine kinase, go to the full flat file.
Word Map on EC 2.7.1.49
Reaction
Synonyms
4-amino-5-hydroxymethyl-2-methyl pyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine (phosphate) kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase, EC 2.7.1.14, EC 2.7.1.35, HMP kinase, HMP-P kinase, HMP/HMP phosphate kinase, HMP/HMP-P kinase, HMPK, HMPPK, HVO_2666, hydroxymethylpyrimidine kinase (phosphorylating), hydroxymethylpyrimidine phosphate kinase, More, pyridoxal kinase, SAV0580, StHMPPK, Thi20, Thi20p, THI3, ThiD, TTHA0680, TtHMPPK
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Reference on EC 2.7.1.49 - hydroxymethylpyrimidine kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kim, Y.S.; Nosaka, K.; Downs, D.M.; Kwak, J.M.; Park, D.; Chung, I.K.; Nam, H.G.
A Brassica cDNA clone encoding a bifunctional hydroxymethylpyrimidine kinase/thiamin-phosphate pyrophosphorylase involved in thiamin biosynthesis
Plant Mol. Biol.
37
955-966
1998
Arabidopsis thaliana, Brassica napus (O48881), Brassica napus
Lewin, L.M.; Brown, G.M.
The biosynthesis of thiamine. III. Mechanism of enzymatic formation of the pyrophosphate ester of 2-methyl-4-amino-5-hydroxymethylpyrimidine
J. Biol. Chem.
236
2768-2771
1961
Saccharomyces cerevisiae
-
Mizote, T.; Nakayama, H.
Purification and properties of hydroxymethylpyrimidine kinase from Escherichia coli
Biochim. Biophys. Acta
991
109-113
1989
Escherichia coli
Reddick, J.J.; Kinsland, C.; Nicewonger, R.; Christian, T.; Downs, D.M.; Winkler, M.E.; Begley, T.P.
Overexpression, purification and characterization of two pyrimidine kinases involved in the biosynthesis of thiamin: 4-amino-5-hydroxymethyl-2-methylpyrimidine kinase and 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase
Tetrahedron
54
15983-15991
1998
Escherichia coli
-
Mizote, T.; Tsuda, M.; Smith, D.D.; Nakayama, H.; Nakazawa, T.
Cloning and characterization of the thiD/J gene of Escherichia coli encoding a thiamin-synthesizing bifunctional enzyme, hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase
Microbiology
145
495-501
1999
Escherichia coli, Escherichia coli (P76422), Escherichia coli BL21(DE3) (pLysS)
Haas, A.L.; Laun, N.P.; Begley, T.P.
Thi20, a remarkable enzyme from Saccharomyces cerevisiae with dual thiamin biosynthetic and degradation activities
Bioorg. Chem.
33
338-344
2005
Saccharomyces cerevisiae (Q08224), Saccharomyces cerevisiae
Kawasaki, Y.; Onozuka, M.; Mizote, T.; Nosaka, K.
Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae
Curr. Genet.
47
156-162
2005
Saccharomyces cerevisiae, Saccharomyces cerevisiae YPH500
Park, J.H.; Burns, K.; Kinsland, C.; Begley, T.P.
Characterization of two kinases involved in thiamine pyrophosphate and pyridoxal phosphate biosynthesis in Bacillus subtilis: 4-amino-5-hydroxymethyl-2methylpyrimidine kinase and pyridoxal kinase
J. Bacteriol.
186
1571-1573
2004
Bacillus subtilis
Rapala-Kozik, M.; Olczak, M.; Ostrowska, K.; Starosta, A.; Kozik, A.
Molecular characterization of thi3 gene involved in thiamine biosynthesis in Zea mays: cDNA sequence and enzymatic and structural properties of recombinant bifunctional protein with 4-amino-5-hydroxymethyl-2-methylpyrimidine (phosphate) kinase and thiamin
Biochem. J.
408
149-159
2007
Zea mays
Wrenger, C.; Eschbach, M.L.; Mueller, I.B.; Laun, N.P.; Begley, T.P.; Walter, R.D.
Vitamin B1 de novo synthesis in the human malaria parasite Plasmodium falciparum depends on external provision of 4-amino-5-hydroxymethyl-2-methylpyrimidine
Biol. Chem.
387
41-51
2006
Plasmodium falciparum
Karunakaran, R.; Ebert, K.; Harvey, S.; Leonard, M.E.; Ramachandran, V.; Poole, P.S.
Thiamine is synthesized by a salvage pathway in Rhizobium leguminosarum bv. viciae strain 3841
J. Bacteriol.
188
6661-6668
2006
Rhizobium leguminosarum
Onozuka, M.; Konno, H.; Kawasaki, Y.; Akaji, K.; Nosaka, K.
Involvement of thiaminase II encoded by the THI20 gene in thiamin salvage of Saccharomyces cerevisiae
FEMS Yeast Res.
8
266-275
2008
Saccharomyces cerevisiae (Q08224)
French, J.B.; Begley, T.P.; Ealick, S.E.
Structure of trifunctional THI20 from yeast
Acta Crystallogr. Sect. D
67
784-791
2011
Saccharomyces cerevisiae (Q08224), Saccharomyces cerevisiae
Nodwell, M.B.; Menz, H.; Kirsch, S.F.; Sieber, S.A.
Rugulactone and its analogues exert antibacterial effects through multiple mechanisms including inhibition of thiamine biosynthesis
ChemBioChem
13
1439-1446
2012
Staphylococcus aureus (P66915)
Castro-Fernandez, V.; Bravo-Moraga, F.; Ramirez-Sarmiento, C.A.; Guixe, V.
Emergence of pyridoxal phosphorylation through a promiscuous ancestor during the evolution of hydroxymethyl pyrimidine kinases
FEBS Lett.
588
3068-3073
2014
Salmonella enterica subsp. enterica serovar Typhimurium (P55882), Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 (P55882)
Nodwell, M.B.; Koch, M.F.; Alte, F.; Schneider, S.; Sieber, S.A.
A subfamily of bacterial ribokinases utilizes a hemithioacetal for pyridoxal phosphate salvage
J. Am. Chem. Soc.
136
4992-4999
2014
Staphylococcus aureus (A0A0H3JTP0), Staphylococcus aureus ATCC 700699 (A0A0H3JTP0)
Cea, P.A.; Araya, G.; Vallejos, G.; Recabarren, R.; Alzate-Morales, J.; Babul, J.; Guixe, V.; Castro-Fernandez, V.
Characterization of hydroxymethylpyrimidine phosphate kinase from mesophilic and thermophilic bacteria and structural insights into their differential thermal stability
Arch. Biochem. Biophys.
688
108389
2020
Salmonella enterica subsp. enterica serovar Typhimurium (P55882), Salmonella enterica subsp. enterica serovar Typhimurium, Thermus thermophilus (Q5SKG3), Thermus thermophilus, Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412 (P55882), Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 (P55882), Thermus thermophilus DSM 579 (Q5SKG3), Thermus thermophilus ATCC 27634 (Q5SKG3)
Thamm, A.M.; Li, G.; Taja-Moreno, M.; Gerdes, S.Y.; de Crecy-Lagard, V.; Bruner, S.D.; Hanson, A.D.
A strictly monofunctional bacterial hydroxymethylpyrimidine phosphate kinase precludes damaging errors in thiamin biosynthesis
Biochem. J.
474
2887-2895
2017
Escherichia coli (P76422), Escherichia coli BW25113 (P76422)
Hwang, S.; Cordova, B.; Abdo, M.; Pfeiffer, F.; Maupin-Furlow, J.
ThiN as a versatile domain of transcriptional repressors and catalytic enzymes of thiamine biosynthesis
J. Bacteriol.
199
e00810-16
2017
Haloferax volcanii (D4GV38), Haloferax volcanii NCIMB 2012 (D4GV38), Haloferax volcanii JCM 8879 (D4GV38), Haloferax volcanii DS2 (D4GV38), Haloferax volcanii DSM 3757 (D4GV38), Haloferax volcanii ATCC 29605 (D4GV38), Haloferax volcanii NBRC 14742 (D4GV38), Haloferax volcanii VKM B-1768 (D4GV38)
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