2.7.1.50: hydroxyethylthiazole kinase
This is an abbreviated version!
For detailed information about hydroxyethylthiazole kinase, go to the full flat file.
Word Map on EC 2.7.1.50
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2.7.1.50
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thiamin
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pyrophosphate
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monophosphate
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salvage
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hydroxymethylpyrimidine
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pyrimidine
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4-amino-5-hydroxymethyl-2-methylpyrimidine
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2.7.1.35
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tpp
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protomers
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pyrophosphorylase
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octamer
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2-methyl-4-amino-5-hydroxymethylpyrimidine
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ribokinase
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antimetabolite
- 2.7.1.50
- thiamin
- pyrophosphate
- monophosphate
-
salvage
- hydroxymethylpyrimidine
- pyrimidine
- 4-amino-5-hydroxymethyl-2-methylpyrimidine
-
2.7.1.35
- tpp
-
protomers
-
pyrophosphorylase
-
octamer
- 2-methyl-4-amino-5-hydroxymethylpyrimidine
- ribokinase
-
antimetabolite
Reaction
Synonyms
4-methyl-5-(beta-hydroxyethyl) thiazole kinase, 4-methyl-5-(beta-hydroxyethyl)thiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase
ECTree
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Reaction
Reaction on EC 2.7.1.50 - hydroxyethylthiazole kinase
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ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphooxyethyl)thiazole
catalytic mechanism of phosphoryl transfer reaction and role of active site residues, e.g. R121 and C198, calculated on the basis of data on crystal structures of ribokinase-like kinases, transition state stabilization involves an oxyanion hole and a magnesium ion
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ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphooxyethyl)thiazole
SN2-like mechanism, with gamma-phosphate acting as an alcohol-activation base. Mg2+ ion 2, residues E126 and C198 play a major catalytic role, whereas Mg2+ ion 1 and C198 are responsible for product release