2.7.1.59: N-acetylglucosamine kinase
This is an abbreviated version!
For detailed information about N-acetylglucosamine kinase, go to the full flat file.
Word Map on EC 2.7.1.59
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2.7.1.59
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albicans
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n-acetylmannosamine
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hexokinases
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glcnac-6-phosphate
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glucosamine-6-phosphate
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aminosugars
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udp-n-acetylglucosamine
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udp-glcnac
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dynlrb1
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n-acetylneuraminic
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dynein
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roadblock
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mannac
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2-epimerase
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analysis
- 2.7.1.59
- albicans
- n-acetylmannosamine
- hexokinases
-
glcnac-6-phosphate
- glucosamine-6-phosphate
-
aminosugars
- udp-n-acetylglucosamine
- udp-glcnac
-
dynlrb1
-
n-acetylneuraminic
- dynein
-
roadblock
- mannac
-
2-epimerase
- analysis
Reaction
Synonyms
2-acetylamino-2-deoxy-D-glucose kinase, acetylaminodeoxyglucokinase, acetylglucosamine kinase(phosphorylating), ATP:2-acetylamino-2-deoxy-D-glucose 6-phosphotransferase, CaNag5p, GlcNAc kinase, GlcNAc-kinase, GNK, Hxk1, MurK, N-acetyl-D-glucosamine kinase, N-acetylglucosamine kinase, N-acetylmuramic acid/N-acetylglucosamine kinase, NAG5, NAGA kinase, NagK
ECTree
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General Information on EC 2.7.1.59 - N-acetylglucosamine kinase
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
evolution
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the enzyme is a member of the BcrAD/BadFGlike ATPase family
malfunction
metabolism
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HXK1 acts as both positive and negative regulator of transcription of genes involved in maintaining cellular homeostasis, regulatory mechanism involved in filamentation repression, overview
physiological function
malfunction
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the homozygous hxk1 mutant H8-1-103 is constitutively filamentous and hyperfilamentous under filamentation inducing conditions
physiological function
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HXK1 plays a crucial role in morphogenesis, GlcNAc signaling/metabolic genes expression and maintenance of various cellular functions in Candida albicans, Hxk1 is involved in the cell wall synthesis and in repression of hyphal specific genes in addition to metabolic genes. Its regulation of filamentation and GlcNAc metabolism is independent of the known classical regulators like EFG1, CPH1, RAS1, TPK2 or TUP1, regulatory mechanism involved in filamentation repression, overview
physiological function
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the enzyme interacts with DYNLRB1 in primary hippocampal neurons
physiological function
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the enzyme promotes the axonal growth of developing neurons
physiological function
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the enzyme regulates white-gray-opaque transitions in Candida albicans
physiological function
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the small domain of the enzyme, and not its kinase activity, plays a critical role in the upregulation of dendritogenesis
physiological function
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the upregulation of dendritic complexity is a non-canonical function of the enzyme
physiological function
enzyme-dynein interaction with the involvements of Lis1 and NudE1 plays an important role in prophase nuclear envelope breakdown and metaphase MT-KT attachment during eukaryotic cell division
physiological function
the enzyme promotes dynein functionality by interacting with dynein light chain roadblock type 1 and efficiently suppressing mutant huntingtin Q74 and alpha-synuclein A53T aggregation in mouse brain cells
