2.7.1.59: N-acetylglucosamine kinase

This is an abbreviated version!
For detailed information about N-acetylglucosamine kinase, go to the full flat file.

Reaction

Synonyms

2-acetylamino-2-deoxy-D-glucose kinase, acetylaminodeoxyglucokinase, acetylglucosamine kinase(phosphorylating), ATP:2-acetylamino-2-deoxy-D-glucose 6-phosphotransferase, CaNag5p, GlcNAc kinase, GlcNAc-kinase, GNK, Hxk1, MurK, N-acetyl-D-glucosamine kinase, N-acetylglucosamine kinase, N-acetylmuramic acid/N-acetylglucosamine kinase, NAG5, NAGA kinase, NagK

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.59 N-acetylglucosamine kinase

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Results	in table
5	Activating Compound
4929	AA Sequence
1	Application
1	CAS Registry Number
15	Cloned(Commentary)
5	Cofactor
1	Crystallization (Commentary)
10	Disease/ Diagnostics
2	Expression
13	General Information
9	General Stability
39	Inhibitors
5	kcat/KM [mM/s]
5	Ki Value [mM]
50	KM Value [mM]
15	Localization
25	Metals/Ions
16	Molecular Weight [Da]
37	Natural Substrates/ Products (Substrates)
39	Organism
4	Pathway
34	PDB ID
9	pH Optimum
1	pH Range
3	pH Stability
13	Protein Variants
20	Purification (Commentary)
1	Reaction
1	Reaction Type
39	Reference
47	Source Tissue
17	Specific Activity [micromol/min/mg]
9	Storage Stability
87	Substrates and Products (Substrate)
9	Subunits
58	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
8	Temperature Stability [°C]
7	Turnover Number [1/s]

Reference

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Reference on EC 2.7.1.59 - N-acetylglucosamine kinase

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

246598

Weidanz, J.A.; Campbell, P.; Moore, D.; deLucas, L.J.; Roden, L.; Thompson, J.N.; Vezza, P.

N-Acetylglucosamine kinase and N-acetylglucosamine 6-phosphate deacetylase in normal human erythrocytes and Plasmodium falciparum

Br. J. Haematol.

95

645-653

1996

Homo sapiens, Plasmodium falciparum

8982040

brenda

641691

Barkulis, S.S.

N-Acetyl-D-glucosamine kinase. I. Steptococcus pyrogenes

Methods Enzymol.

9

415-420

1966

Streptococcus pyogenes, Streptococcus pyogenes 523

-

brenda

641692

Asensio, C.; Ruiz-Amil, M.

N-Acetyl-D-glucosamine kinase. II. Escherichia coli

Methods Enzymol.

9

421-425

1966

Escherichia coli

-

brenda

641693

Datta, A.

Studies on hog spleen N-acetylglucosamine kinase. I. Purification and properties of N-acetylglucosamine kinase

Biochim. Biophys. Acta

220

51-60

1970

Capra hircus, Sus scrofa

4319609

brenda

641694

Gindzienski, A.; Glowacka, D.; Zwierz, K.

Purification and properties of N-acetylglucosamine kinase from human gastric mucosa

Eur. J. Biochem.

43

155-160

1974

Homo sapiens

4365241

brenda

641695

Datta, A.

N-Acetyl-D-glucosamine kinase from hog spleen

Methods Enzymol.

42c

58-62

1975

Sus scrofa

-

brenda

641696

Rai, Y.P.; Singh, B.; Elango, N.; Datta, A.

Purification and some properties of inducible N-acetylglucosamine kinase from Candida albicans

Biochim. Biophys. Acta

614

350-356

1980

Candida albicans

6250622

brenda

641697

Allen, M.B.; Walker, D.G.

Kinetic characterization of N-acetyl-D-glucosamine kinase from rat liver and kidney

Biochem. J.

185

577-582

1980

Rattus norvegicus

6248026

brenda

641698

Allen, M.B.; Walker, D.G.

The isolation and preliminary characterization of N-acetyl-D-glucosamine kinase from rat kidney and liver

Biochem. J.

185

565-575

1980

Rattus norvegicus

6248025

brenda

641700

Hinderlich, S.; Nohring, S.; Weise, C.; Franke, P.; Stasche, R.; Reutter, W.

Purification and characterization of N-acetylglucosamine kinase from rat liver. Comparison with UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

Eur. J. Biochem.

252

133-139

1998

Rattus norvegicus

9523722

brenda

641701

Hinderlich, S.; Berger, M.; Schwarzkopf, M.; Effertz, K.; Reutter, W.

Molecular cloning and characterization of murine and human N-acetylglucosamine kinase

Eur. J. Biochem.

267

3301-3308

2000

Mus musculus (Q9QZ08), Mus musculus, Homo sapiens (Q9UJ70), Homo sapiens

10824116

brenda

641702

Yamada-Okabe, T.; Sakamori, Y.; Mio, T.; Yamada-Okabe, H.

Identification and characterization of the genes for N-acetylglucosamine kinase and N-acetylglucosamine-phosphate deacetylase in the pathogenic fungus Candida albicans

Eur. J. Biochem.

268

2498-2505

2001

Candida albicans, Homo sapiens

11298769

brenda

641703

Berger, M.; Chen, H.; Reutter, W.; Hinderlich, S.

Structure and function of N-acetylglucosamine kinase. Identification of two active site cysteines

Eur. J. Biochem.

269

4212-4218

2002

Mus musculus

12199699

brenda

659055

Uehara, T.; Park, J.T.

The N-acetyl-D-glucosamine kinase of Escherichia coli and its role in murein recycling

J. Bacteriol.

186

7273-7279

2004

Escherichia coli

15489439

brenda

675413

Weihofen, W.A.; Berger, M.; Chen, H.; Saenger, W.; Hinderlich, S.

Structures of human N-acetylglucosamine kinase in two complexes with N-acetylglucosamine and with ADP/glucose: insights into substrate specificity and regulation

J. Mol. Biol.

364

388-399

2006

Homo sapiens (Q9UJ70), Homo sapiens

17010375

brenda

702223

Blume, A.; Berger, M.; Benie, A.J.; Peters, T.; Hinderlich, S.

Characterization of ligand binding to N-acetylglucosamine kinase studied by STD NMR

Biochemistry

47

13138-13146

2008

Homo sapiens (Q9UJ70), Homo sapiens

19006331

brenda

722301

Scarcelli, J.J.; Colussi, P.A.; Fabre, A.L.; Boles, E.; Orlean, P.; Taron, C.H.

Uptake of radiolabeled GlcNAc into Saccharomyces cerevisiae via native hexose transporters and its in vivo incorporation into GPI precursors in cells expressing heterologous GlcNAc kinase

FEMS Yeast Res.

12

305-316

2012

no activity in Saccharomyces cerevisiae, Candida albicans (Q59RG5)

22151002

brenda

722533

Reith, J.; Berking, A.; Mayer, C.

Characterization of an N-acetylmuramic acid/N-acetylglucosamine kinase of Clostridium acetobutylicum

J. Bacteriol.

193

5386-5392

2011

Clostridium acetobutylicum

21784936

brenda

723600

Rao, K.H.; Ghosh, S.; Natarajan, K.; Datta, A.

N-acetylglucosamine kinase, HXK1 is involved in morphogenetic transition and metabolic gene expression in Candida albicans

PLoS ONE

8

e53638

2013

Candida albicans

23341961

brenda

738177

Islam, M.A.; Sharif, S.R.; Lee, H.; Seog, D.H.; Moon, I.S.

N-acetyl-D-glucosamine kinase interacts with dynein light-chain roadblock type 1 at Golgi outposts in neuronal dendritic branch points

Exp. Mol. Med.

47

e177

2015

Rattus norvegicus

26272270

brenda

738241

Furo, K.; Nozaki, M.; Murashige, H.; Sato, Y.

Identification of an N-acetylglucosamine kinase essential for UDP-N-acetylglucosamine salvage synthesis in Arabidopsis

FEBS Lett.

589

3258-3262

2015

Arabidopsis thaliana

26408204

brenda

738315

Cao, C.; Guan, G.; Du, H.; Tao, L.; Huang, G.

Role of the N-acetylglucosamine kinase (Hxk1) in the regulation of white-gray-opaque tristable phenotypic transitions in C. albicans

Fungal Genet. Biol.

92

26-32

2016

Candida albicans

27153757

brenda

739070

Lee, H.; Cho, S.J.; Moon, I.S.

The non-canonical effect of N-acetyl-D-glucosamine kinase on the formation of neuronal dendrites

Mol. Cells

37

248-256

2014

Rattus norvegicus

24625575

brenda

739071

Lee, H.; Dutta, S.; Moon, I.S.

Upregulation of dendritic arborization by N-acetyl-D-glucosamine kinase is not dependent on its kinase activity

Mol. Cells

37

322-329

2014

Rattus norvegicus

24722415

brenda

739072

Sharif, S.R.; Lee, H.; Islam, M.A.; Seog, D.H.; Moon, I.S.

N-acetyl-D-glucosamine kinase is a component of nuclear speckles and paraspeckles

Mol. Cells

38

402-408

2015

Rattus norvegicus

25921606

brenda

739073

Islam, M.A.; Sharif, S.R.; Lee, H.; Moon, I.S.

N-acetyl-D-glucosamine kinase promotes the axonal growth of developing neurons

Mol. Cells

38

876-885

2015

Homo sapiens

26467288

brenda

739411

Flores, C.L.; Gancedo, C.

The gene YALI0E20207g from Yarrowia lipolytica encodes an N-acetylglucosamine kinase implicated in the regulated expression of the genes from the N-acetylglucosamine assimilatory pathway

PLoS ONE

10

e0122135

2015

Yarrowia lipolytica, Yarrowia lipolytica CJM936

25816199

brenda

739441

Felice, M.R.; Gulati, M.; Giuffre, L.; Giosa, D.; Di Bella, L.M.; Criseo, G.; Nobile, C.J.; Romeo, O.; Scordino, F.

Molecular characterization of the n-acetylglucosamine catabolic genes in Candida africana, a natural N-acetylglucosamine kinase (HXK1) mutant

PLoS ONE

11

e0147902

2016

Candida africana, Candida africana CBS11016, Candida africana UPV/EHU 97135

26808192

brenda

759020

Ripon, M.K.H.; Lee, H.; Dash, R.; Choi, H.J.; Oktaviani, D.F.; Moon, I.S.; Haque, M.N.

N-acetyl-D-glucosamine kinase binds dynein light chain roadblock 1 and promotes protein aggregate clearance

Cell Death Dis.

11

619

2020

Mus musculus (Q9QZ08), Mus musculus

32796833

brenda

759773

Sharif, S.R.; Islam, A.; Moon, I.S.

N-acetyl-D-glucosamine kinase interacts with dynein-Lis1-NudE1 complex and regulates cell division

Mol. Cells

39

669-679

2016

Homo sapiens (Q9UJ70)

27646688

brenda

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