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2.7.1.60: N-acylmannosamine kinase

This is an abbreviated version!
For detailed information about N-acylmannosamine kinase, go to the full flat file.

Word Map on EC 2.7.1.60

Reaction

ATP
+
N-acyl-D-mannosamine
=
ADP
 +
N-acyl-D-mannosamine 6-phosphate

Synonyms

acetylamidodeoxymannokinase, acetylmannosamine kinase, acylaminodeoxymannokinase, acylmannosamine kinase, acylmannosamine kinase (phosphorylating), ATP:N-acetylmannosamine 6-phosphotransferase, EC 2.7.1.59/EC 2.7.1.60, EC 5.1.3.14/EC 2.7.1.60, GNE, GNE2, GNE3, ManAc kinase, MNK, N-acetylmannosamine kinase, N-acetylmannosamine-6-phosphate 2-epimerase, N-acyl-D-mannosamine kinase, nanK, UDP-GlcNAc 2-epimerase/ManAc kinase, UDP-GlcNAc 2-epimerase/ManNAc 6-kinase, UDP-GlcNAc 2-epimerase/ManNAc kinase, UDP-GlcNAc-2 epimerase/ManNAc kinase, UDP-GlcNAc-epimerase/ManNAc kinase, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine-kinase, UDP-N-acetylglucosamine2-epimerase/N-acetylmannosamine kinase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.60 N-acylmannosamine kinase

Disease

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Disease on EC 2.7.1.60 - N-acylmannosamine kinase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Carcinoma
Loss of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) induces apoptotic processes in pancreatic carcinoma cells.
Distal Myopathies
A Novel Mutation of the GNE Gene in Distal Myopathy with Rimmed Vacuoles: A Case with Inflammation.
Novel Mutations of the GNE Gene in Distal Myopathy with Rimmed Vacuoles Presenting with Very Slow Progression.
Liver Cirrhosis, Biliary
Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis.
Liver Diseases, Alcoholic
Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis.
Muscular Diseases
A Novel Mutation of the GNE Gene in Distal Myopathy with Rimmed Vacuoles: A Case with Inflammation.
GNE myopathy: current update and future therapy.
Heterozygous UDP-GlcNAc 2-epimerase and N-acetylmannosamine kinase domain mutations in the GNE gene result in a less severe GNE myopathy phenotype compared to homozygous N-acetylmannosamine kinase domain mutations.
Respiratory dysfunction in patients severely affected by GNE myopathy (distal myopathy with rimmed vacuoles).
Use of a cell-free system to determine UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase activities in human hereditary inclusion body myopathy.
Sialic Acid Storage Disease
Increased Polysialylation of the Neural Cell Adhesion Molecule in a Transgenic Mouse Model of Sialuria.