2.7.1.67: 1-phosphatidylinositol 4-kinase

This is an abbreviated version!
For detailed information about 1-phosphatidylinositol 4-kinase, go to the full flat file.

Word Map on EC 2.7.1.67

2.7.1.67

4-phosphate

4,5-bisphosphate

phospholipid

phospholipase

ptdins4p

wortmannin

phosphatidylinositol-4-phosphate

pip2

5-kinase

diacylglycerol

polyphosphoinositides

ptdins4,5p2

phosphatidic

trans-golgi

gamma-32patp

1,4,5-trisphosphate

phosphatidylinositol-4,5-bisphosphate

polyoma

coxsackievirus

wortmannin-sensitive

pleckstrin

antiphosphotyrosine

oxysterol-binding

positive-sense

enteroviruses

3hinositol

ovcar-5

sensor-1

ns5a

poliovirus

medicine

pharmacology

drug development

Reaction

1-phosphatidyl-1D-myo-inositol 4-phosphate

Synonyms

1-phosphatidyl-1D-myo-inositol 4-phosphotransferase, 56 kDa type II PtdIns 4-kinase, alpha type II PI 4-kinase, AtPI4KIIIalpha1, AtPI4KIIIbeta1, AtPI4KIIIbeta2, beta type II PI 4-kinase, beta-type phosphatidylinositol 4-kinase, kinase, phosphatidylinositol (phosphorylating), Lsb6, Lsb6p, phosphatidyl-inositol 4-kinase type IIIalpha, phosphatidylinositol 4 kinase, phosphatidylinositol 4 kinase IIIbeta, phosphatidylinositol 4-kinase, phosphatidylinositol 4-kinase beta, phosphatidylinositol 4-kinase beta1, phosphatidylinositol 4-kinase IIalpha, phosphatidylinositol 4-kinase IIbeta, phosphatidylinositol 4-kinase III alpha, phosphatidylinositol 4-kinase IIIalpha, phosphatidylinositol 4-kinase IIIbeta, phosphatidylinositol 4-kinase IIIbeta,, phosphatidylinositol 4-kinase type 2-alpha, phosphatidylinositol 4-kinase type II, phosphatidylinositol 4-kinase type II alpha, phosphatidylinositol 4-kinase type IIalpha, phosphatidylinositol 4-kinase type IIbeta, phosphatidylinositol 4-kinase type-III alpha, phosphatidylinositol kinase, phosphatidylinositol-4-kinase, phosphatidylinositol-4-kinase IIalpha, phosphatidylinositol-4-kinase III beta, phosphatidylinositol-4-kinase type II alpha, phosphatidylinositol-4-kinase type IIalpha, PI 4-kinase, PI 4-kinase type IIalpha, PI kinase, PI-4 kinase, PI4-kinase, PI4K, PI4K beta, PI4K IIalpha, PI4K IIbeta, PI4K IIIbeta, PI4K2, PI4K230, PI4K2A, PI4K55, PI4K92, PI4KA, PI4KB, PI4Kbeta, PI4Kbeta1, PI4Kgamma3, PI4Kgamma5, PI4KII, PI4KIIalpha, PI4KIIbeta, PI4KIII-beta, PI4KIIIalpha, PI4KIIIbeta, Pik1, Pik1p, PIK230, Pik2p, Pik4ca, PIK4IIalpha, PIK4IIbeta, PIK4IIIalpha, PIK4IIIbeta, PIK55, PIKCB, PtdIns 4-kinase, PtdIns 4-kinase beta, PtdIns4KIIalpha, Stt4p, type II phosphatidylinositol 4-kinase, type II phosphatidylinositol kinase, type II phosphoinositide 4-kinase, type II PI 4-kinase enzyme, type II PI4Kalpha, type II PtdIns 4-kinase, type IIalpha phosphatidylinositol 4-kinase, type III alpha phosphatidylinositol 4-kinase, type III phosphatidylinositol 4-kinase alpha, type III phosphatidylinositol 4-kinase beta, type III PI 4-kinase beta, type III PI4K, type III PI4Kbeta, type-II PI4K, type-III phosphatidylinositol 4-kinase beta1, type-III phosphatidylinositol 4-kinase beta2, type-III PI4K

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.67 1-phosphatidylinositol 4-kinase

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Results	in table
70	Activating Compound
10362	AA Sequence
3	Application
1	CAS Registry Number
33	Cloned(Commentary)
31	Cofactor
5	Crystallization (Commentary)
330	Disease/ Diagnostics
3	Expression
63	General Information
1	General Stability
160	IC50 Value
470	Inhibitors
42	Ki Value [mM]
72	KM Value [mM]
166	Localization
74	Metals/Ions
49	Molecular Weight [Da]
71	Natural Substrates/ Products (Substrates)
155	Organism
4	Pathway
49	PDB ID
27	pH Optimum
14	pH Range
1	pH Stability
1	pI Value
10	Posttranslational Modification
26	Protein Variants
47	Purification (Commentary)
5	Reaction
1	Reaction Type
144	Reference
1	Renatured (Commentary)
131	Source Tissue
17	Specific Activity [micromol/min/mg]
7	Storage Stability
164	Substrates and Products (Substrate)
29	Subunits
242	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
2	Temperature Range [°C]
9	Temperature Stability [°C]
4	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 2.7.1.67 - 1-phosphatidylinositol 4-kinase

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100000

SDS-PAGE

110000

SDS-PAGE

120000

122000

analytical ultracentrifugation

759678

125000

Saccharomyces cerevisiae

x * 125000, SDS-PAGE

641784

126000

Arabidopsis thaliana

calculated from amino acid sequence

676541

130000

Homo sapiens

Q9UBF8

calculated from amino acid sequence

150000

gel filtration

200000

enzyme type I, gel filtration

230000

240000

gel filtration

35000

Saccharomyces cerevisiae

x * 35000, SDS-PAGE

44000

SDS-PAGE

45000

46730

calculated from amino acid sequence

676541

50000

Homo sapiens

x * 50000, SDS-PAGE

641797

54000

Saccharomyces cerevisiae

calculated from amino acid sequence

677233

54305

Bos taurus

x * 54305, calculation from nucleotide sequence

641812

55000

9 entries

550000

Homo sapiens

cPIK-I and cPIK-II, gel filtration

56000

x * 56000, SDS-PAGE

59000

x * 59000, SDS-PAGE

60000

gel filtration

65000

x * 65000, SDS-PAGE

66000

calculated from amino acid sequence

76000

80000

83000

gel filtration

91000

isozyme PI4KIIIbeta

92000

additional information

Homo sapiens

the enzyme binds substantial amounts of Triton X-100 and is actually present in detergent-containing solutions as a complex with a molecular weight of 120000 Da. It seems likely that the active species of the enzyme is a single 55000 Da polypeptide chain bound to essentially one Triton X-100 micelle

641768