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2.7.1.68: 1-phosphatidylinositol-4-phosphate 5-kinase

This is an abbreviated version!
For detailed information about 1-phosphatidylinositol-4-phosphate 5-kinase, go to the full flat file.

Word Map on EC 2.7.1.68

Reaction

ATP
+
1-phosphatidyl-1D-myo-inositol 4-phosphate
=
ADP
 +
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Synonyms

Diphosphoinositide kinase, More, Mss4, MSS4p, phosphatidylinositol 4,5-biphosphate kinase, phosphatidylinositol 4-phosphate 5-kinase, phosphatidylinositol 4-phosphate 5-kinase 2, phosphatidylinositol 4-phosphate 5-kinase alpha, phosphatidylinositol 4-phosphate 5-kinase beta, phosphatidylinositol 4-phosphate 5-kinase gamma, phosphatidylinositol 4-phosphate 5-kinase gamma661, phosphatidylinositol 4-phosphate 5-kinase Igamma, phosphatidylinositol 4-phosphate 5-kinase Igamma b, phosphatidylinositol 4-phosphate 5-kinase Igamma_i2, phosphatidylinositol 4-phosphate 5-kinase Igamma_v3, phosphatidylinositol 4-phosphate 5-kinase Igamma_v6, phosphatidylinositol 4-phosphate 5-kinase-Ibeta, phosphatidylinositol 4-phosphate kinase, phosphatidylinositol 5-kinase gamma, phosphatidylinositol kinase type I, phosphatidylinositol monophosphate 5-kinase, phosphatidylinositol phosphate 5-kinase, phosphatidylinositol phosphate 5-kinase 1, phosphatidylinositol phosphate 5-kinase 10, phosphatidylinositol phosphate 5-kinase Ibeta, phosphatidylinositol phosphate 5-kinase Igammai2, phosphatidylinositol phosphate kinase type I gamma, phosphatidylinositol-4-phosphate 5' kinase, phosphatidylinositol-4-phosphate 5-kinase, phosphatidylinositol-4-phosphate 5-kinase gamma 635, phosphatidylinositol-4-phosphate 5-kinase1alpha, phosphatidylinositol4-phosphate 5-kinase, phosphoinositol-4-phosphate-5-kinase, PI 4-phosphate 5-kinase, PI(4)P 5-kinase, PI(4)P5-K, PI4P 5-kinase, PI4P5K, PIP kinase, PIP-5kin, PIP5K, PIP5K type I, PIP5K type Ialpha, PIP5K-Ib, PIP5K1, PIP5K1A, PIP5K1alpha, PIP5K1gamma, PIP5K2, PIP5K3, PIP5K9, PIP5Kalpha, PIP5Kbeta, PIP5Kgamma, PIP5Kgamma635, PIP5Kgamma661, PIP5KI, PIP5KI gamma, PIP5KIalpha, PIP5KIbeta, PIP5KIgamma, PIP5KIgamma_i2, PIP5KIgamma_v3, PIP5KIgamma_v6, PIP5Ks, PIPK, PIPK1, PIPK10, PIPK1gamma-87, PIPKalpha, PIPKI, PIPKIalpha, PIPKIgamma, PIPKIgammaI2, PIPKIgammai5, PIPkin, PIPkin Igammab, PIPkinIgamma93, ppk-1, PtdIns(4)P 5-kinase, PtdIns(4)P kinase, PtdIns4P5K, PtdInsP, type 1 phosphatidylinositol-4-phosphate 5-kinase, type I gamma phosphatidylinositol phosphate 5-kinase i5, type I phosphatidylinositol 4-phosphate 5-kinase, type I phosphatidylinositol 4-phosphate 5-kinase gamma, type I phosphatidylinositol phosphate 5-kinase, type I phosphatidylinositol-4-phosphate 5-kinase, type I phosphatidylinositol-4-phosphate 5-kinase alpha, type I phosphatidylinositol-4-phosphate 5-kinase gamma, type I PI 4-phosphate 5-kinase, type I PtdInsP kinase, type Igamma phosphatidylinositol 4-phosphate 5-kinase, type Igamma PIP 5-kinase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.68 1-phosphatidylinositol-4-phosphate 5-kinase

Activating Compound

Activating Compound on EC 2.7.1.68 - 1-phosphatidylinositol-4-phosphate 5-kinase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,2-diarachidonoyl phosphatidic acid
-
-
1,2-dilinoleoyl phosphatidic acid
-
-
1,2-dioleoyl phosphatidic acid
-
-
1-arachidoyl-2-arachidonoyl phosphatidic acid
-
-
1-stearoyl-2-arachidonoyl phosphatidic acid
-
-
1-stearoyl-2-oleoyl phosphatidic acid
-
-
Acetylcholine
-
0.01 mM or 0.1 mM, each in presence of 0.1 mM eserine, stimulates the enzyme in homogenates by 30-40%
ADP-ribosylation factor 1
-
0.001 mM
-
ADP-ribosylation factor 6
-
0.001 mM
-
advanced glycation end products
-
Ajuba
-
dramatic activation of enzymatic activity
-
AP-2mu-endocytic cargo complex
-
clathrin adaptor complex, leads to a potent stimulation of PIPK activity
-
Arf6
-
activates the enzyme via binding of small GTPase Rac1, regulatory function, mutant Arf6 N121I is defective for nucleotide binding, mutant Q67L is similarly active as the wild-type Arf6
-
beta2 adaptin
-
the beta2 subunit of beta2 adaptin binds to the C-terminal tail of PIP5Kgamma661 and causes activation of the enzyme
-
CD28
-
heparin
-
type I enzyme is stimulated at low concentrations
lipid phosphatidate
-
0.1 mM
-
lysophosphatidic acid
myelin basic protein
-
enhances activity when phosphatidylinositol 4-phosphate/phosphatidylethanolamine vesicles are used as substrate
-
phosphatidic acid
small G protein ARF
-
ARF activation absolutely requires the presence of phosphatidic acid, which cannot be substituted by phosphatidylserine, phosphatidylethanolamine, or lysophosphatidic acid, but by competitive phosphatidylcholine, reconstitution of the recombinant either isozyme alpha, beta, or gamma with recombinant class II and III ARFs, ARF5 and ARF6, respectively, as well as myristoylated class I ARF in presence of GTPgammaS or GDP, and phosphatidic acid activates the isozymes
-
small G protein RHO
-
activates the enzyme in neurits, crucial in cell shapig together with the enzyme, overview
-
small G proteins
-
-
-
small G proteins ARF
-
small GTPase Arf
-
small GTPase ARF/phosphatidic acid
-
regulation of isozyme gamma
-
small GTPase Rho
-
spermidine
-
enhances activity
spermine
Triton X-100
additional information
-