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evolution
PIP5K sequences and inferred apicomplexan PIP5K gene tree, overview
evolution
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PIP5K sequences and inferred apicomplexan PIP5K gene tree, overview
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malfunction
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enzyme knockoout mutants are infertile, phenotypes, overview. Flagella of sperm from isozyme Pip5k1a knockout mutant and even more of Pip5k1a/Pip5k1b double-knockout mutant mice remarkably undergo morphological changes and impairment, whereas Pip5k1b-knockout mutant sperm is morphologically normal. F-actin organization in the seminiferous epithelium is disrupted by the loss of PIP5K1A and PIP5K1B
malfunction
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isozyme PIP5Kalpha knockdown reduces 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate levels and disrupts Toll/IL-1 receptor domain-containing adaptor protein membrane targeting by lipopolysaccharide
malfunction
isozyme PIP5Kalpha knockdown reduces 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate levels and disrupts Toll/IL-1 receptor domain-containing adaptor protein membrane targeting by lipopolysaccharide. Isozyme PIP5Kalpha shRNA-15 knockdown cells are less effective inducing iNOS protein expression and nitric oxide production after lipopolysaccharide stimulation overnight and for 24 h, respectively, compared with control cells
malfunction
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overexpression of PIPKalpha inhibits axon elongation via KIF2A in N1E-115 neuroblastoma cells
malfunction
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enzyme knockdown affects the recruitment of talin and focal adhesion kinase to the plasma membrane
malfunction
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enzyme knockdown impairs Akt activation in response to both FBS and ECM protein stimulation
malfunction
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enzyme mutants exhibit shorter root hairs than the wild type and remained responsive to phosphate deficiency in root hair elongation
malfunction
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enzyme silencing impairs CD28-mediated IL-8 and IL-2 transcriptional activation
malfunction
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the loss of function of isoforms PIP5K1 and PIP5K2 produces defects on vacuoles and exine wall in pollen grains
malfunction
downregulation of isoforms PIP5K1alpha and PIP5K1gamma strongly impairs the targeting of HIV-1 Gag polyprotein precursor Pr55Gag to the plasma membrane with a rerouting of the polyprotein within intracellular compartments
malfunction
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isoform PIP5Kalpha knockdown of BV-2 cells significantly suppresses lipoteichoic acid-induced activation of toll-like receptor 2 downstream signaling, including the production of proinflammatory cytokines and phosphorylation of nuclear factor-kappaB, JNK, and p38 MAP kinase. Besides, isoform PIP5Kalpha knockdown inhibits phagocytic uptake of Escherichia coli particles and autophagy-related vesicle formation triggered by lipoteichoic acid
malfunction
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knockdown of isoform PIPKIgammai5 leads to the loss of mitogen-inducible gene 6 expression, which dramatically enhances and prolongs epidermal growth factor receptor-mediated cell signaling
metabolism
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phosphorylation of 1-phosphatidyl-1D-myo-inositol 4-phosphate by the type I PI 4-phosphate 5-kinase (PIP5K) family members including PIP5Kalpha, PIP5Kbeta, and PIP5Kgamma isoforms is the major pathway of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis in mammalian cells
metabolism
phosphorylation of 1-phosphatidyl-1D-myo-inositol 4-phosphate by the type I PI 4-phosphate 5-kinase (PIP5K) family members including PIP5Kalpha, PIP5Kbeta, and PIP5Kgamma isoforms is the major pathway of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis in mammalian cells
metabolism
enzyme isoform PIP5KIgamma regulates KCNQ2/3 currents and store-operated calcium entry in distinct ways in tsA201 cells
metabolism
enzyme isoforms PIP5KIbeta regulates KCNQ2/3 currents and store-operated calcium entry in distinct ways in tsA201 cells
metabolism
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isoform PIP5K2 interacts physically with alpha-importin isoforms IMPalpha6 and IMPalpha9
physiological function
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1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate regulates many critical cellular events and mediates plasma membrane localization of the Toll/IL-1 receptor domain-containing adaptor protein (TIRAP), required for the MyD88-dependent Toll-like receptor 4 signaling pathway. Phosphatidylinositol 4-phosphate 5-kinase alpha facilitates toll-like receptor 4-mediated microglial inflammation through regulation of the toll/interleukin-1 receptor domain-containing adaptor protein location
physiological function
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate regulates many critical cellular events and mediates plasma membrane localization of the Toll/IL-1 receptor domain-containing adaptor protein (TIRAP), required for the MyD88-dependent Toll-like receptor 4 signaling pathway. Phosphatidylinositol 4-phosphate 5-kinase alpha facilitates toll-like receptor 4-mediated microglial inflammation through regulation of the toll/interleukin-1 receptor domain-containing adaptor protein location
physiological function
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isozyme phosphatidylinositol 4-phosphate 5-kinase alpha, PIPKalpha, regulates neuronal microtubule depolymerase kinesin, KIF2A and suppresses elongation of axon branches, unique PIPK-mediated KIF2A-dependent mechanism controlling microtubule dynamics in neuronal development, overview. Murine PIPKalpha as a negative regulator of neurite formation in N1E-115 neuroblastoma cells and early-stage hippocampal neurons
physiological function
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phosphatidylinositol 4,5 bisphosphate is a major membrane phospholipid that affects cellular processes such as actin cytoskeleton modulation, membrane trafficking and ion channel activity. Isozyme PIP5Kgamma is essential for advanced glycation end products induced inhibition of renal Na+/K+ ATPase activity
physiological function
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phosphatidylinositol 4,5 bisphosphate is a major membrane phospholipid that affects cellular processes such as actin cytoskeleton modulation, membrane trafficking and ion channel activity. Isozyme PIP5Kgamma is essential for advanced glycation end products induced inhibition of renal Na+/K+ ATPase activity
physiological function
phosphatidylinositol 4-phosphate 5-kinase play an important role in host-cell invasion by the Eimeria species. The protozoan parasites can cause severe intestinal disease in livestock
physiological function
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the lipid kinase phosphatidylinositol 4-phosphate 5-kinase produces a versatile signaling phospholipid, phosphatidylinositol 4,5-bisphosphate, isozymes PIP5K1A and PIP5K1B may coordinately and/or redundantly function in the maintenance of sperm number and morphology during spermatogenesis
physiological function
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CD28 induces the recruitment of the enzyme to the immunological synapse, where it regulates filamin A and lipid raft accumulation, as well as T cell activation, in a nonredundant manner
physiological function
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enzyme overexpression promotes class I PI3K and the serine/threoninespecific protein kinase Akt signaling and oncogenic growth
physiological function
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enzyme PIP5Kalpha acts as a negative regulator of nerve growth factor-induced neurite outgrowth by inhibiting phosphatidylinositol 3-kinase/Akt signaling pathway in PC-12 cells
physiological function
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isoform PIP5K3 and PIP5K4 are redundantly required for the root hair elongation response at young seedling stages
physiological function
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phosphatidylinositol 4-phosphate 5-kinases 1 and 2 are involved in the regulation of vacuole morphology during Arabidopsis thaliana pollen development. Both isoforms are involved in protein trafficking to the vacuole in root tip epidermal cells
physiological function
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T lymphocyte triggering is finely tuned by phosphatidylinositol 4,5-biphosphate kinases activity
physiological function
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the enzyme and sorting nexin 5 protein form a signaling nexus that controls epidermal growth factor receptor endosomal sorting, degradation, and signaling
physiological function
the enzyme functions as a member of the rDNA silencing complex
physiological function
the enzyme interacts with the cytoskeleton regulator IQGAP1 and modulates IQ motif containing GTPase activating protein 1 (IQGAP1) function in migration. The enzyme is required for IQGAP1 recruitment to the leading edge membrane in response to integrin or growth factor receptor activation
physiological function
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the enzyme is a key modulator of CD28 costimulatory signals and required for CD28-mediated transcription of both interleukin-8 and interleukin-2 genes
physiological function
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the enzyme is a key modulator of CD28 costimulatory signals leading to the efficient T cell activation. Enzyme recruitment and activation is essential for CD28-mediated cytoskeleton rearrangement necessary for organizing a complete signaling compartment leading to downstream signaling functions
physiological function
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the enzyme negatively regulates axon elongation and growth cone size and is involved in the cellular signaling pathway for Sema3A-triggered repulsion in dorsal root ganglion neurons
physiological function
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the enzyme plays an essential role in neuronal migration, possibly through recruitment of adhesion components to the plasma membrane
physiological function
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the enzyme prevents the decrease in the HRG (human ether-a-go-go-related gene) potassium current induced by Gq protein-coupled receptor stimulation
physiological function
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the enzyme regulates Src activation downstream of growth factor receptors and integrins. The enzyme and Src synergistically control anchorage-independent tumor cell growth
physiological function
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isoform PIPKIgammai5 controls Mig6 ubiquitination and degradation. Isoform PIPKIgammai5, the E3 ubiquitin ligase neuronal precursor cell-expressed developmentally down-regulated 4-1, and mitogen-inducible gene 6 form a molecular nexus that controls epidermal growth factor receptor activation and downstream signalling
physiological function
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overexpression of isoform PIP5K1A results in significant enhancement of non-amyloidogenic amyloid precursor protein processing and a concomitant suppression of the amyloidogenic pathway, leading to a marked decrease in secreted amyloid-beta peptide
physiological function
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phosphatidylinositol 4-phosphate 5-kinase alpha contributes to toll-like receptor 2-mediated immune responses in microglial cells stimulated with lipoteichoic acid
physiological function
the 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate pools produced by isoforms PIP5K1alpha and gamma are involved in HIV-1 Gag polyprotein precursor Pr55Gag plasma membrane targeting process
physiological function
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phosphatidylinositol 4-phosphate 5-kinase play an important role in host-cell invasion by the Eimeria species. The protozoan parasites can cause severe intestinal disease in livestock
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additional information
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identification of the binding domain for His6-tagged KIF2A and GST-tagged PIPKalpha interaction, overview
additional information
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upon activation by semaphorin 3E, plexin-D1 recruits phosphatidylinositol-4-phosphate 5-kinase, and its enzymatic lipid product, phosphatidylinositol 4,5-bisphosphate, binds to the pleckstrin homology domain of guanine nucleotide exchange protein 100, GEP100. Phosphatidylinositol 4,5-bisphosphate binding to GEP100 enhances its guanine nucleotide exchange factor activity toward Arf6, thus resulting in the disassembly of integrin-mediated focal adhesions and endothelial cell collapse