2.7.1.71: shikimate kinase

This is an abbreviated version!
For detailed information about shikimate kinase, go to the full flat file.

Reaction

Synonyms

adenosine triphosphate: shikimate-3-phosphotransferase, AroK, AroL, AtSK1, AtSK2, kinase (phosphorylating), shikimate, kinase, shikimate (phosphorylating), MtSK, OsSK1, OsSK2, OsSK3, Rv2539c, shikimate kinase II, shikimate kinase-like 1, SK I, SK II, SK1, SK2, SKI, SKII, SKL1, type I shikimate kinase, aroK-encoded, type II shikimate kinase

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.71 shikimate kinase

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Results	in table
45743	AA Sequence
7	Application
1	CAS Registry Number
19	Cloned(Commentary)
16	Cofactor
20	Crystallization (Commentary)
1	Expression
22	General Information
5	General Stability
14	IC50 Value
185	Inhibitors
8	kcat/KM [mM/s]
88	Ki Value [mM]
44	KM Value [mM]
1	Localization
51	Metals/Ions
28	Molecular Weight [Da]
49	Natural Substrates/ Products (Substrates)
731	Organism
6	Pathway
70	PDB ID
6	pH Optimum
2	pH Range
3	pI Value
1	Posttranslational Modification
33	Protein Variants
20	Purification (Commentary)
3	Reaction
1	Reaction Type
99	Reference
2	Renatured (Commentary)
10	Source Tissue
6	Specific Activity [micromol/min/mg]
5	Storage Stability
101	Substrates and Products (Substrate)
20	Subunits
51	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
2	Temperature Range [°C]
5	Temperature Stability [°C]
15	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.7.1.71 - shikimate kinase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.00858

(2E)-3-(4-hydroxy-3-methoxyphenyl)-2-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]prop-2-enenitrile

Mycobacterium tuberculosis

-

at pH 7.6 and 25°C

737517

0.00875

(2E)-N-(3-acetylphenyl)-3-(4-nitrophenyl)prop-2-enamide

Mycobacterium tuberculosis

-

at pH 7.6 and 25°C

737517

0.00968

(2E,5Z)-5-[4-(dimethylamino)benzylidene]-2-(2-oxo-2-phenylethylidene)-1,3-thiazolidin-4-one

Mycobacterium tuberculosis

-

at pH 7.6 and 25°C

737517

0.01069

2-[(2Z)-2-(4-nitrobenzylidene)hydrazinyl]-1,3-benzothiazole

Mycobacterium tuberculosis

-

at pH 7.5 and 25°C

758891

0.00675

2-[(4-aminophenyl)amino]-3-(piperidin-1-yl)naphthalene-1,4-dione

Mycobacterium tuberculosis

-

at pH 7.6 and 25°C

737517

0.00584

2-[(4-chlorophenyl)amino]-N-(5-oxo-4,5-dihydro-1H-pyrazol-3-yl)acetamide

Mycobacterium tuberculosis

-

at pH 7.5 and 25°C

758891

0.0055

3-methoxy-4-[[2-([2-methoxy-4-[(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]methyl)benzyl]oxy]benzaldehyde

Helicobacter pylori

-

in 100 mM Tris–HCl (pH 8.0), 50 mM KCl, 5 mM MgCl2, 2 mM ATP, 2 mM phosphoenolpyruvate, 0.7 mM NADH, 3 U/ml proteinase K, 2.5 U/ml lactate dehydrogenase, and 2 mM shikimate, at 25°C

672569

0.0064

5-bromo-2-(5-[[1-(3,4-dichlorophenyl)-3,5-dioxo-4-pyrazolidinylidene]methyl]-2-furyl)benzoic acid

Helicobacter pylori

-

in 100 mM Tris–HCl (pH 8.0), 50 mM KCl, 5 mM MgCl2, 2 mM ATP, 2 mM phosphoenolpyruvate, 0.7 mM NADH, 3 U/ml proteinase K, 2.5 U/ml lactate dehydrogenase, and 2 mM shikimate, at 25°C

672569

0.0051

5-[[(5-chloro-2-hydroxyphenyl)amino]methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

2 entries

0.00006

6-cyclohexamidomanzamine A

Mycobacterium tuberculosis

-

at pH 7.5 and 25°C

758891

0.01

manzamine A

Mycobacterium tuberculosis

-

at pH 7.5 and 25°C

758891

0.04622

N-(5,7-dimethyl-1,3-benzothiazol-2-yl)-2-methoxybenzamide

Mycobacterium tuberculosis

-

at pH 7.5 and 25°C

758891

0.0049

NSC162535

Helicobacter pylori

P56073

pH 7.5, 25°C

723553

0.0051

5-[[(5-chloro-2-hydroxyphenyl)amino]methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

Mycobacterium tuberculosis

-

at pH 7.5 and 25°C

758891

0.0051

5-[[(5-chloro-2-hydroxyphenyl)amino]methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

Mycobacterium tuberculosis

-

at pH 7.6 and 25°C

737517