Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.7.1.74: deoxycytidine kinase

This is an abbreviated version!
For detailed information about deoxycytidine kinase, go to the full flat file.

Word Map on EC 2.7.1.74

Reaction

NTP
+
deoxycytidine
=
NDP
+
dCMP

Synonyms

2'-deoxycytidine kinase, ara-C kinase, arabinofuranosylcytosine kinase, dC kinase, dCK, deoxycytidine kinase, deoxycytidine-cytidine kinase, dNTP:deoxycytidine 5'-phosphotransferase, kinase, deoxycytidine (phosphorylating), NTP:deoxycytidine 5'-phosphotransferase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.74 deoxycytidine kinase

Activating Compound

Activating Compound on EC 2.7.1.74 - deoxycytidine kinase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-beta-D-arabinosylcytosine
-
i.e. cytarabine, 0.001 mM, stimulation
2'-deoxyadenosine/deoxycoformycin
-
no stimulation of enzyme activity by either compound if applied alone, with both compound at 0.01 mM 2.4fold activation occurs
2'-deoxythymidine-5'-thiosulphate
-
in intact cells, activation, reversed by 2’-deoxycytidine
2-chloro-2'-arabino-fluoro-2'-deoxyadenosine
-
0.001 mM, stimulation
2-chloro-2'-deoxy-2'-fluoro-arabinosyladenine
-
stimulation
2-chloro-2'-deoxyadenosine
2-fluoro-1-beta-D-arabinosyladenine
-
i.e. fludarabine, 0.001 mM, stimulation
AG-490
-
-
aphidicolin
arabinosylcytidine
-
stimulation
ATP
-
substrate activation, at high concentrations of deoxycytidine
bovine serum albumin
-
activation
-
calyculin A
-
inhibitor of protein phosphatases, activation
CHAPS
-
slight stimulation, deoxycytidine as substrate
daidzein
-
-
deoxyadenosine
-
activation, deoxycytidine as substrate, mitochondrial isozyme
deoxyguanosine
-
activation, deoxycytidine as substrate, mitochondrial isozyme
dithiothreitol
etoposide
gamma-radiation
-
0.5-2 GY dosage, activation
-
genistein
NaCl
-
at 0.2-0.4 M, stimulation of 2’-deoxycytidine and 2-chlorodeoxyadenosine phosphorylation, but inhibition of 2’-deoxyguanosine phosphorylation
NaF
-
15 mM, 1 h, activity about twice as high as initial level
okadaic acid
-
-
paclitaxel
-
paclitaxel increases dCK (10% to 50%) activity
PD 153035
-
i.e. 4-(3-bromoanilino)-6,7-dimethoxy-quinazinoline
PD 98059
-
i.e. 2'-amino-3'-methoxyflavone, in absence of deoxycytidine
PD-98059
-
-
protein transporter ABCG2
-
the ABC transporter activates the enzyme and reduces intracellular accumulation of clofarabine
-
SB 203580
-
in absence of deoxycytidine
sodium cholate
-
slight stimulation, deoxycytidine as substrate
TTP
-
stimulation, cytosolic isozyme I
tyrphostin A47
-
-
UDP
-
stimulation, mitochondrial isozyme
Uridine arabinoside
-
activation, deoxycytidine as substrate, mitochondrial isozyme
Zwittergent 3-14
-
slight stimulation, deoxycytidine as substrate
additional information
-