2.7.1.74: deoxycytidine kinase
This is an abbreviated version!
For detailed information about deoxycytidine kinase, go to the full flat file.
Word Map on EC 2.7.1.74
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2.7.1.74
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leukemia
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gemcitabine
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thymidine
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triphosphate
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deaminase
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purine
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ribonucleotide
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deoxynucleoside
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pyrimidine
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deoxyguanosine
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salvage
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myeloid
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arabinoside
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cytarabine
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prodrugs
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deoxyadenosine
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1-beta-d-arabinofuranosylcytosine
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deoxyribonucleoside
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5'-nucleotidase
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cladribine
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cross-resistance
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ara-ctp
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2-chlorodeoxyadenosine
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2',2'-difluorodeoxycytidine
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fludarabine
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dttp
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antileukemic
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ccrf-cem
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dfdctp
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2-chloro-2'-deoxyadenosine
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gemcitabine-resistant
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dado
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deoxycytidylate
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kinase-deficient
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clofarabine
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2',3'-dideoxycytidine
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5'-phosphorylation
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arabinosyl
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deoxypyrimidine
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t-lymphoblastoid
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deoxycoformycin
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medicine
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2'-deoxyadenosine
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deoxythymidine
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l-nucleoside
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dideoxycytidine
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t-lymphoblasts
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2',3'-dideoxyinosine
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tetrahydrouridine
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arabinosylcytosine
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anabolites
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pharmacology
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analysis
- 2.7.1.74
- leukemia
- gemcitabine
- thymidine
- triphosphate
- deaminase
- purine
- ribonucleotide
- deoxynucleoside
- pyrimidine
- deoxyguanosine
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salvage
- myeloid
- arabinoside
- cytarabine
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prodrugs
- deoxyadenosine
- 1-beta-d-arabinofuranosylcytosine
- deoxyribonucleoside
- 5'-nucleotidase
- cladribine
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cross-resistance
- ara-ctp
- 2-chlorodeoxyadenosine
- 2',2'-difluorodeoxycytidine
- fludarabine
- dttp
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antileukemic
-
ccrf-cem
-
dfdctp
- 2-chloro-2'-deoxyadenosine
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gemcitabine-resistant
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dado
- deoxycytidylate
-
kinase-deficient
- clofarabine
- 2',3'-dideoxycytidine
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5'-phosphorylation
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arabinosyl
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deoxypyrimidine
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t-lymphoblastoid
- deoxycoformycin
- medicine
- 2'-deoxyadenosine
- deoxythymidine
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l-nucleoside
- dideoxycytidine
- t-lymphoblasts
- 2',3'-dideoxyinosine
- tetrahydrouridine
- arabinosylcytosine
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anabolites
- pharmacology
- analysis
Reaction
Synonyms
2'-deoxycytidine kinase, ara-C kinase, arabinofuranosylcytosine kinase, dC kinase, dCK, deoxycytidine kinase, deoxycytidine-cytidine kinase, dNTP:deoxycytidine 5'-phosphotransferase, kinase, deoxycytidine (phosphorylating), NTP:deoxycytidine 5'-phosphotransferase
ECTree
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Activating Compound
Activating Compound on EC 2.7.1.74 - deoxycytidine kinase
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2'-deoxyadenosine/deoxycoformycin
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no stimulation of enzyme activity by either compound if applied alone, with both compound at 0.01 mM 2.4fold activation occurs
2'-deoxythymidine-5'-thiosulphate
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in intact cells, activation, reversed by 2-deoxycytidine
2-fluoro-1-beta-D-arabinosyladenine
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i.e. fludarabine, 0.001 mM, stimulation
NaCl
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at 0.2-0.4 M, stimulation of 2-deoxycytidine and 2-chlorodeoxyadenosine phosphorylation, but inhibition of 2-deoxyguanosine phosphorylation
protein transporter ABCG2
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the ABC transporter activates the enzyme and reduces intracellular accumulation of clofarabine
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Uridine arabinoside
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activation, deoxycytidine as substrate, mitochondrial isozyme
2-chloro-2'-deoxyadenosine
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2.4fold activation at 0.003 mM, activation is slightly inhibited by 3-aminobenzamide, the activation of the enzyme is a first step in 2-chloro-2'-deoxyadenosine-induced cytotoxicity
2-chloro-2'-deoxyadenosine
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increases activity by increasing phosphorylation of Ser74
aphidicolin
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increases dCK activity via Ser74 phosphorylation, effect of aphidicolin treatment on dCK activity in leukemic cells with substrate deoxycytidine and cladribine and other substrates, overview
additional information
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enzyme is activated by inhibitors of signal transduction enzymes, overview, deoxycytidine prevents activation of the enzyme, no activation by PD 98059 and SB 203580 in presence of deoxycytidine
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additional information
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2- to 3-fold activation of enzyme by UV-C light irradiation
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additional information
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enzyme protein level increases when cells are incubated with cyclopentenyl cytosine
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additional information
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irradiation of intact cells increases enzyme activity, upregulation of activity might be caused by phosphorylation
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additional information
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UV-C irradiation increases activity by increasing phosphorylation of Ser74
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additional information
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the enzyme is activated in response to DNA damage. The ataxia-telangiectasia-mutated (ATM) kinase phosphorylates dCK on Serine 74 to activate it in response to DNA damage
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additional information
the enzyme is activated in response to ionizing radiation
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