2.7.1.74: deoxycytidine kinase
This is an abbreviated version!
For detailed information about deoxycytidine kinase, go to the full flat file.
Word Map on EC 2.7.1.74
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2.7.1.74
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leukemia
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gemcitabine
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thymidine
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triphosphate
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deaminase
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purine
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ribonucleotide
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deoxynucleoside
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pyrimidine
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deoxyguanosine
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salvage
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myeloid
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arabinoside
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cytarabine
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prodrugs
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deoxyadenosine
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1-beta-d-arabinofuranosylcytosine
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deoxyribonucleoside
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5'-nucleotidase
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cladribine
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cross-resistance
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ara-ctp
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2-chlorodeoxyadenosine
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2',2'-difluorodeoxycytidine
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fludarabine
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dttp
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antileukemic
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ccrf-cem
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dfdctp
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2-chloro-2'-deoxyadenosine
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gemcitabine-resistant
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dado
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deoxycytidylate
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kinase-deficient
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clofarabine
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2',3'-dideoxycytidine
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5'-phosphorylation
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arabinosyl
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deoxypyrimidine
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t-lymphoblastoid
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deoxycoformycin
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medicine
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2'-deoxyadenosine
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deoxythymidine
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l-nucleoside
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dideoxycytidine
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t-lymphoblasts
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2',3'-dideoxyinosine
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tetrahydrouridine
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arabinosylcytosine
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anabolites
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pharmacology
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analysis
- 2.7.1.74
- leukemia
- gemcitabine
- thymidine
- triphosphate
- deaminase
- purine
- ribonucleotide
- deoxynucleoside
- pyrimidine
- deoxyguanosine
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salvage
- myeloid
- arabinoside
- cytarabine
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prodrugs
- deoxyadenosine
- 1-beta-d-arabinofuranosylcytosine
- deoxyribonucleoside
- 5'-nucleotidase
- cladribine
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cross-resistance
- ara-ctp
- 2-chlorodeoxyadenosine
- 2',2'-difluorodeoxycytidine
- fludarabine
- dttp
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antileukemic
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ccrf-cem
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dfdctp
- 2-chloro-2'-deoxyadenosine
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gemcitabine-resistant
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dado
- deoxycytidylate
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kinase-deficient
- clofarabine
- 2',3'-dideoxycytidine
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5'-phosphorylation
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arabinosyl
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deoxypyrimidine
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t-lymphoblastoid
- deoxycoformycin
- medicine
- 2'-deoxyadenosine
- deoxythymidine
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l-nucleoside
- dideoxycytidine
- t-lymphoblasts
- 2',3'-dideoxyinosine
- tetrahydrouridine
- arabinosylcytosine
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anabolites
- pharmacology
- analysis
Reaction
Synonyms
2'-deoxycytidine kinase, ara-C kinase, arabinofuranosylcytosine kinase, dC kinase, dCK, deoxycytidine kinase, deoxycytidine-cytidine kinase, dNTP:deoxycytidine 5'-phosphotransferase, kinase, deoxycytidine (phosphorylating), NTP:deoxycytidine 5'-phosphotransferase
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Application on EC 2.7.1.74 - deoxycytidine kinase
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analysis
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deoxycytidine kinase from B-cell chronic lymphocytic leukaemia lymphocytes can be detected by use of anti-phospho-ser74 antibodies
medicine
pharmacology
additional information
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deoxycytidine kinase is a key enzyme in the activation of several therapeutic nucleoside analogues
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direct inhibition of DNA polymerases by aphidicolin stimulated enzyme in normal, acute myeloid leukaemic and HL60 promyelocytic cells
medicine
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recombinant enzyme in human A-549 lung carcinoma cells or murine NIH3T3 fibroblast cells, increase in cytotoxicity of cytosine arabinoside, 5'-aza-2'-deoxycytidine, decrease in toxicity of 2',2'-difluorodeoxycytidine
medicine
enzyme is active and important in anticancer and antiviral therapy due to high phosphorylation activity of prodrugs, overview
medicine
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deoxycytidine kinase overexpression substantially increases both the toxic and radiosensitizing effects of gemcitabine. Enhancement is mild in murine GI261 cells and much stronger in rat C6 and human U373 cells. Combination of enzyme overexpression, gemcitabine treatment and irradiation improves the survival rate of C6 cell bearing rats significantly
medicine
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in gemcitabine-resistant pancreatic cancer cells, expression of deoxycytidine kinase is significantly reduced compared with that of parental cells. Treatment with siRNA targeted to deoxycytidine kinase reduces gemcitabine sensitivity without affecting cell proliferation. Downregulation of gemcitabine-related genes RRM1 and RRM2 by siRNA increases gemcitabine sensitivity and reduces cell proliferation even without gemcitabine treatment
medicine
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interindividual variability in deoxycytidine kinase activity is related to its phosphorylation level on residue Ser74
medicine
sequencing of gene from European and African individuals reveals 64 genetic polymorphisms. In general, African ancestry subjects show higher mRNA expression compared with subjects with European ancestry. In both groups, single nucleotide polymorphism 35708 C>T of a 3'-untranslated region is significantly associated with lower mRNA expression and with lower blast 1-beta-D-arabinofuranosylcytosine 5'-triphosphate levels in acute myeloid leukemia patients
medicine
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thymocytes lacking adenosine deaminase activity accumulate intracellular dATP and undergo apoptosis. Inhibition of deoxycytidine kinase prevents the accumulation of dATP and induction of apoptosis to a large degree, inhibition of both deoxycytidine kinase and adenosine kinase completely abrogates accumulation of dATP and significantly reduces the induction of apoptosis
medicine
ability of the designer enzymes to activate 5-substitued pyrimidines makes it possible to utilize such nucleoside analogs in suicide gene therapy or protein therapy applications that target cancer cells
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the enzyme is a critical determinant of therapeutic activity for several nucleoside analogue prodrugs
pharmacology
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the enzyme is a critical determinant of therapeutic activity for several nucleoside analogue prodrugs
pharmacology
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the enzyme is a critical determinant of therapeutic activity for several nucleoside analogue prodrugs
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